An N-Acyliminium Cyclization Approach to a Total Synthesis of (+)-Cylindricine C
Liu, Jia, Swidorski, Jacob J, Peters, Scott D, Hsung, Richard P
Published in Journal of organic chemistry (13.05.2005)
Published in Journal of organic chemistry (13.05.2005)
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Journal Article
Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2,4-dihydro-3 H -1,2,4-triazole-3-thione
Yoon, David S, Liu, Chunjian, Jalagam, Prasada Rao, Feng, Jianxin, Wang, Wei, Swidorski, Jacob J, Xu, Li, Hartz, Richard A, Nair, Satheesh K, Beno, Brett R, Panda, Manoranjan, Ghosh, Kaushik, Kumar, Amit, Sale, Harinath, Shah, Devang, Mathur, Arvind, Ellsworth, Bruce A, Cheng, Dong, Regueiro-Ren, Alicia
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin‑3 Comprising 2‑Methyl-4-phenyl-2,4-dihydro‑3H‑1,2,4-triazole-3-thione
Yoon, David S., Liu, Chunjian, Jalagam, Prasada Rao, Feng, Jianxin, Wang, Wei, Swidorski, Jacob J., Xu, Li, Hartz, Richard A., Nair, Satheesh K., Beno, Brett R., Panda, Manoranjan, Ghosh, Kaushik, Kumar, Amit, Sale, Harinath, Shah, Devang, Mathur, Arvind, Ellsworth, Bruce A., Cheng, Dong, Regueiro-Ren, Alicia
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage
Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Li, Zhufang, Zhang, Sharon, Sun, Yongnian, Samanta, Himadri, Terry, Brian, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J, Chen, Jie, Venables, Brian L, Healy, Matthew, Meanwell, Nicholas A, Cockett, Mark, Hanumegowda, Umesh, Regueiro-Ren, Alicia, Krystal, Mark, Dicker, Ira B
Published in Antimicrobial agents and chemotherapy (01.07.2016)
Published in Antimicrobial agents and chemotherapy (01.07.2016)
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Journal Article
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV‑1 Maturation
Regueiro-Ren, Alicia, Sit, Sing-Yuen, Chen, Yan, Chen, Jie, Swidorski, Jacob J., Liu, Zheng, Venables, Brian L., Sin, Ny, Hartz, Richard A., Protack, Tricia, Lin, Zeyu, Zhang, Sharon, Li, Zhufang, Wu, Dauh-Rurng, Li, Peng, Kempson, James, Hou, Xiaoping, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Park, Hyunsoo, Sarjeant, Amy, Benitex, Yulia, Rahematpura, Sandhya, Parker, Dawn, Phillips, Thomas, Haskell, Roy, Jenkins, Susan, Santone, Kenneth S., Cockett, Mark, Hanumegowda, Umesh, Dicker, Ira, Meanwell, Nicholas A., Krystal, Mark
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Journal Article
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition
Swidorski, Jacob J., Jenkins, Susan, Hanumegowda, Umesh, Parker, Dawn D., Beno, Brett R., Protack, Tricia, Ng, Alicia, Gupta, Anuradha, Shanmugam, Yoganand, Dicker, Ira B., Krystal, Mark, Meanwell, Nicholas A., Regueiro-Ren, Alicia
Published in Bioorganic & medicinal chemistry letters (15.03.2021)
Published in Bioorganic & medicinal chemistry letters (15.03.2021)
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Journal Article
The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation
Chen, Yan, Sit, Sing-Yuen, Chen, Jie, Swidorski, Jacob J., Liu, Zheng, Sin, Ny, Venables, Brian L., Parker, Dawn D., Nowicka-Sans, Beata, Lin, Zeyu, Li, Zhufang, Terry, Brian J., Protack, Tricia, Rahematpura, Sandhya, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Dicker, Ira D., Meanwell, Nicholas A., Regueiro-Ren, Alicia
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
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Journal Article
Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis
Swidorski, Jacob J., Beno, Brett R., Liu, Chunjian, Yoon, David S., Ghosh, Kaushik, Sale, Harinath, Shah, Devang, Acharya, Kriti, Yanchunas, Joseph, Haldar, Priyanka, Kalidindi, Narasimharaju, Shukla, Jinal K., Argentieri, Matthew, Ellsworth, Bruce A., Cheng, Dong, Regueiro-Ren, Alicia
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Journal Article
Inhibitors of HIV-1 attachment: The discovery and structure–activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore
Swidorski, Jacob J., Liu, Zheng, Yin, Zhiwei, Wang, Tao, Carini, David J., Rahematpura, Sandhya, Zheng, Ming, Johnson, Kim, Zhang, Sharon, Lin, Pin-Fang, Parker, Dawn D., Li, Wenying, Meanwell, Nicholas A., Hamann, Lawrence G., Regueiro-Ren, Alicia
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
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Journal Article
Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 12. Structure–Activity Relationships Associated with 4‑Fluoro-6-azaindole Derivatives Leading to the Identification of 1‑(4-Benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl‑1H‑pyrrolo[2,3‑c]pyridin-3-yl)ethane-1,2-dione (BMS-585248)
Regueiro-Ren, Alicia, Xue, Qiufen M, Swidorski, Jacob J, Gong, Yi-Fei, Mathew, Marina, Parker, Dawn D, Yang, Zheng, Eggers, Betsy, D’Arienzo, Celia, Sun, Yongnian, Malinowski, Jacek, Gao, Qi, Wu, Dedong, Langley, David R, Colonno, Richard J, Chien, Caly, Grasela, Dennis M, Zheng, Ming, Lin, Pin-Fang, Meanwell, Nicholas A, Kadow, John F
Published in Journal of medicinal chemistry (28.02.2013)
Published in Journal of medicinal chemistry (28.02.2013)
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Journal Article
Inhibitors of HIV-1 maturation: Development of structure–activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids
Swidorski, Jacob J., Liu, Zheng, Sit, Sing-Yuen, Chen, Jie, Chen, Yan, Sin, Ny, Venables, Brian L., Parker, Dawn D., Nowicka-Sans, Beata, Terry, Brian J., Protack, Tricia, Rahematpura, Sandhya, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Dicker, Ira B., Meanwell, Nicholas A., Regueiro-Ren, Alicia
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
Published in Bioorganic & medicinal chemistry letters (15.04.2016)
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Journal Article
C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors
Liu, Zheng, Swidorski, Jacob J., Nowicka-Sans, Beata, Terry, Brian, Protack, Tricia, Lin, Zeyu, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Parker, Dawn D., Rahematpura, Sandhya, Jenkins, Susan, Beno, Brett R., Krystal, Mark, Meanwell, Nicholas A., Dicker, Ira B., Regueiro-Ren, Alicia
Published in Bioorganic & medicinal chemistry (15.04.2016)
Published in Bioorganic & medicinal chemistry (15.04.2016)
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Journal Article
Discovery of BMS-955176, a Second Generation HIV‑1 Maturation Inhibitor with Broad Spectrum Antiviral Activity
Regueiro-Ren, Alicia, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J, Chen, Jie, Venables, Brian L, Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Beno, Brett R, Huang, Xiaohua S, Rahematpura, Sandhya, Parker, Dawn D, Haskell, Roy, Jenkins, Susan, Santone, Kenneth S, Cockett, Mark I, Krystal, Mark, Meanwell, Nicholas A, Hanumegowda, Umesh, Dicker, Ira B
Published in ACS medicinal chemistry letters (09.06.2016)
Published in ACS medicinal chemistry letters (09.06.2016)
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Journal Article
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176)
Regueiro-Ren, Alicia, Swidorski, Jacob J, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Chen, Jie, Venables, Brian L, Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Easter, John, Beno, Brett R, Arora, Vinod, Huang, Xiaohua S, Rahematpura, Sandhya, Parker, Dawn D, Haskell, Roy, Santone, Kenneth S, Cockett, Mark I, Krystal, Mark, Meanwell, Nicholas A, Jenkins, Susan, Hanumegowda, Umesh, Dicker, Ira B
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Journal Article
A Lewis Acid-Catalyzed Formal [3 + 3] Cycloaddition of α,β-Unsaturated Aldehydes with 4-Hydroxy-2-Pyrone, Diketones, and Vinylogous Esters
Kurdyumov, Aleksey V, Lin, Nan, Hsung, Richard P, Gullickson, Glen C, Cole, Kevin P, Sydorenko, Nadiya, Swidorski, Jacob J
Published in Organic letters (19.01.2006)
Published in Organic letters (19.01.2006)
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Journal Article
Design, Synthesis, and SAR of C‑3 Benzoic Acid, C‑17 Triterpenoid Derivatives. Identification of the HIV‑1 Maturation Inhibitor 4‑((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)‑3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro‑1H‑cyclopenta[a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176)
Regueiro-Ren, Alicia, Swidorski, Jacob J., Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Chen, Jie, Venables, Brian L., Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Easter, John, Beno, Brett R., Arora, Vinod, Huang, Xiaohua S., Rahematpura, Sandhya, Parker, Dawn D., Haskell, Roy, Santone, Kenneth S., Cockett, Mark I., Krystal, Mark, Meanwell, Nicholas A., Jenkins, Susan, Hanumegowda, Umesh, Dicker, Ira B.
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Journal Article
Invention of VH-937, a Potent HIV-1 Maturation Inhibitor with the Potential for Infrequent Oral Dosing in Humans
Sit, Sing-Yuen, Chen, Yan, Chen, Jie, Venables, Brian L., Swidorski, Jacob J., Xu, Li, Sin, Ny, Hartz, Richard A., Lin, Zeyu, Zhang, Sharon, Li, Zhufang, Wu, Dauh-Rurng, Li, Peng, Kempson, James, Hou, Xiaoping, Shanmugam, Yoganand, Parker, Dawn, Jenkins, Susan, Simmermacher, Jean, Falk, Paul, McAuliffe, Brian, Cockett, Mark, Hanumegowda, Umesh, Dicker, Ira, Krystal, Mark, Meanwell, Nicholas A., Regueiro-Ren, Alicia
Published in ACS medicinal chemistry letters (17.10.2024)
Published in ACS medicinal chemistry letters (17.10.2024)
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