Tau association with synaptic vesicles causes presynaptic dysfunction
Zhou, Lujia, McInnes, Joseph, Wierda, Keimpe, Holt, Matthew, Herrmann, Abigail G., Jackson, Rosemary J., Wang, Yu-Chun, Swerts, Jef, Beyens, Jelle, Miskiewicz, Katarzyna, Vilain, Sven, Dewachter, Ilse, Moechars, Diederik, De Strooper, Bart, Spires-Jones, Tara L., De Wit, Joris, Verstreken, Patrik
Published in Nature communications (11.05.2017)
Published in Nature communications (11.05.2017)
Get full text
Journal Article
PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling
Morais, Vanessa A., Haddad, Dominik, Craessaerts, Katleen, De Bock, Pieter-Jan, Swerts, Jef, Vilain, Sven, Aerts, Liesbeth, Overbergh, Lut, Grünewald, Anne, Seibler, Philip, Klein, Christine, Gevaert, Kris, Verstreken, Patrik, De Strooper, Bart
Published in Science (American Association for the Advancement of Science) (11.04.2014)
Published in Science (American Association for the Advancement of Science) (11.04.2014)
Get full text
Journal Article
Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy
Uytterhoeven, Valerie, Lauwers, Elsa, Maes, Ine, Miskiewicz, Katarzyna, Melo, Manuel N., Swerts, Jef, Kuenen, Sabine, Wittocx, Rafaël, Corthout, Nikky, Marrink, Siewert-Jan, Munck, Sebastian, Verstreken, Patrik
Published in Neuron (Cambridge, Mass.) (18.11.2015)
Published in Neuron (Cambridge, Mass.) (18.11.2015)
Get full text
Journal Article
The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals
Vanhauwaert, Roeland, Kuenen, Sabine, Masius, Roy, Bademosi, Adekunle, Manetsberger, Julia, Schoovaerts, Nils, Bounti, Laura, Gontcharenko, Serguei, Swerts, Jef, Vilain, Sven, Picillo, Marina, Barone, Paolo, Munshi, Shashini T, de Vrij, Femke MS, Kushner, Steven A, Gounko, Natalia V, Mandemakers, Wim, Bonifati, Vincenzo, Meunier, Frederic A, Soukup, Sandra‐Fausia, Verstreken, Patrik
Published in The EMBO journal (15.05.2017)
Published in The EMBO journal (15.05.2017)
Get full text
Journal Article
Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification
Dejonghe, Wim, Kuenen, Sabine, Mylle, Evelien, Vasileva, Mina, Keech, Olivier, Viotti, Corrado, Swerts, Jef, Fendrych, Matyáš, Ortiz-Morea, Fausto Andres, Mishev, Kiril, Delang, Simon, Scholl, Stefan, Zarza, Xavier, Heilmann, Mareike, Kourelis, Jiorgos, Kasprowicz, Jaroslaw, Nguyen, Le Son Long, Drozdzecki, Andrzej, Van Houtte, Isabelle, Szatmári, Anna-Mária, Majda, Mateusz, Baisa, Gary, Bednarek, Sebastian York, Robert, Stéphanie, Audenaert, Dominique, Testerink, Christa, Munnik, Teun, Van Damme, Daniël, Heilmann, Ingo, Schumacher, Karin, Winne, Johan, Friml, Jiří, Verstreken, Patrik, Russinova, Eugenia
Published in Nature communications (08.06.2016)
Published in Nature communications (08.06.2016)
Get full text
Journal Article
Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration
Fernandes, Ana Clara, Uytterhoeven, Valerie, Kuenen, Sabine, Wang, Yu-Chun, Slabbaert, Jan R, Swerts, Jef, Kasprowicz, Jaroslaw, Aerts, Stein, Verstreken, Patrik
Published in The Journal of cell biology (24.11.2014)
Published in The Journal of cell biology (24.11.2014)
Get full text
Journal Article
Endophilin-B regulates autophagy during synapse development and neurodegeneration
Hernandez-Diaz, Sergio, Ghimire, Saurav, Sanchez-Mirasierra, Irene, Montecinos-Oliva, Carla, Swerts, Jef, Kuenen, Sabine, Verstreken, Patrik, Soukup, Sandra-Fausia
Published in Neurobiology of disease (01.02.2022)
Published in Neurobiology of disease (01.02.2022)
Get full text
Journal Article
Excess Lipin enzyme activity contributes to TOR1A recessive disease and DYT-TOR1A dystonia
Cascalho, Ana, Foroozandeh, Joyce, Hennebel, Lise, Swerts, Jef, Klein, Christine, Rous, Stef, Dominguez Gonzalez, Beatriz, Pisani, Antonio, Meringolo, Maria, Gallego, Sandra F, Verstreken, Patrik, Seibler, Philip, Goodchild, Rose E
Published in Brain (London, England : 1878) (01.06.2020)
Published in Brain (London, England : 1878) (01.06.2020)
Get full text
Journal Article
Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release
Khuong, Thang Manh, Habets, Ron L.P., Kuenen, Sabine, Witkowska, Agata, Kasprowicz, Jaroslaw, Swerts, Jef, Jahn, Reinhard, van den Bogaart, Geert, Verstreken, Patrik
Published in Neuron (Cambridge, Mass.) (20.03.2013)
Published in Neuron (Cambridge, Mass.) (20.03.2013)
Get full text
Journal Article
Aconitase causes iron toxicity in Drosophila pink1 mutants
Esposito, Giovanni, Vos, Melissa, Vilain, Sven, Swerts, Jef, De Sousa Valadas, Jorge, Van Meensel, Stefanie, Schaap, Onno, Verstreken, Patrik
Published in PLoS genetics (01.04.2013)
Published in PLoS genetics (01.04.2013)
Get full text
Journal Article
ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot
Miśkiewicz, Katarzyna, Jose, Liya E., Bento-Abreu, André, Fislage, Marcus, Taes, Ines, Kasprowicz, Jarosław, Swerts, Jef, Sigrist, Stephan, Versées, Wim, Robberecht, Wim, Verstreken, Patrik
Published in Neuron (Cambridge, Mass.) (08.12.2011)
Published in Neuron (Cambridge, Mass.) (08.12.2011)
Get full text
Journal Article
Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1
Jacquemyn, Julie, Kuenen, Sabine, Swerts, Jef, Pavie, Benjamin, Vijayan, Vinoy, Kilic, Ayse, Chabot, Dries, Wang, Yu-Chun, Schoovaerts, Nils, Corthout, Nikky, Verstreken, Patrik
Published in NPJ Parkinson's Disease (04.02.2023)
Published in NPJ Parkinson's Disease (04.02.2023)
Get full text
Journal Article
HDAC6 Is a Bruchpilot Deacetylase that Facilitates Neurotransmitter Release
Miskiewicz, Katarzyna, Jose, Liya E., Yeshaw, Wondwossen M., Valadas, Jorge S., Swerts, Jef, Munck, Sebastian, Feiguin, Fabian, Dermaut, Bart, Verstreken, Patrik
Published in Cell reports (Cambridge) (10.07.2014)
Published in Cell reports (Cambridge) (10.07.2014)
Get full text
Journal Article
Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function
Fischer, Baptiste, Lüthy, Kevin, Paesmans, Jone, De Koninck, Charlotte, Maes, Ine, Swerts, Jef, Kuenen, Sabine, Uytterhoeven, Valerie, Verstreken, Patrik, Versées, Wim
Published in Nature structural & molecular biology (26.09.2016)
Published in Nature structural & molecular biology (26.09.2016)
Get full text
Journal Article
A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals
Soukup, Sandra-Fausia, Kuenen, Sabine, Vanhauwaert, Roeland, Manetsberger, Julia, Hernández-Díaz, Sergio, Swerts, Jef, Schoovaerts, Nils, Vilain, Sven, Gounko, Natalia V., Vints, Katlijn, Geens, Ann, De Strooper, Bart, Verstreken, Patrik
Published in Neuron (Cambridge, Mass.) (23.11.2016)
Published in Neuron (Cambridge, Mass.) (23.11.2016)
Get full text
Journal Article
Neuronal identity defines α-synuclein and tau toxicity
Praschberger, Roman, Kuenen, Sabine, Schoovaerts, Nils, Kaempf, Natalie, Singh, Jeevanjot, Janssens, Jasper, Swerts, Jef, Nachman, Eliana, Calatayud, Carles, Aerts, Stein, Poovathingal, Suresh, Verstreken, Patrik
Published in Neuron (Cambridge, Mass.) (17.05.2023)
Published in Neuron (Cambridge, Mass.) (17.05.2023)
Get full text
Journal Article
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation
Largo-Barrientos, Pablo, Apóstolo, Nuno, Creemers, Eline, Callaerts-Vegh, Zsuzsanna, Swerts, Jef, Davies, Caitlin, McInnes, Joseph, Wierda, Keimpe, De Strooper, Bart, Spires-Jones, Tara, de Wit, Joris, Uytterhoeven, Valerie, Verstreken, Patrik
Published in Neuron (Cambridge, Mass.) (03.03.2021)
Published in Neuron (Cambridge, Mass.) (03.03.2021)
Get full text
Journal Article
Torsin and NEP1R1‐CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid‐dependent and lipid‐independent mechanisms
Jacquemyn, Julie, Foroozandeh, Joyce, Vints, Katlijn, Swerts, Jef, Verstreken, Patrik, Gounko, Natalia V, Gallego, Sandra F, Goodchild, Rose
Published in The EMBO journal (01.09.2021)
Published in The EMBO journal (01.09.2021)
Get full text
Journal Article
Hsp90 Mediates Membrane Deformation and Exosome Release
Lauwers, Elsa, Wang, Yu-Chun, Gallardo, Rodrigo, Van der Kant, Rob, Michiels, Emiel, Swerts, Jef, Baatsen, Pieter, Zaiter, Samantha S., McAlpine, Shelli R., Gounko, Natalia V., Rousseau, Frederic, Schymkowitz, Joost, Verstreken, Patrik
Published in Molecular cell (06.09.2018)
Published in Molecular cell (06.09.2018)
Get full text
Journal Article