Identification and Biological Evaluation of 4-(3-Trifluoromethylpyridin-2-yl)piperazine-1-carboxylic Acid (5-Trifluoromethylpyridin-2-yl)amide, a High Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist
Swanson, Devin M, Dubin, Adrienne E, Shah, Chandra, Nasser, Nadia, Chang, Leon, Dax, Scott L, Jetter, Michele, Breitenbucher, J. Guy, Liu, Changlu, Mazur, Curt, Lord, Brian, Gonzales, Lisa, Hoey, Kenway, Rizzolio, Michele, Bogenstaetter, Michael, Codd, Ellen E, Lee, Doo H, Zhang, Sui-Po, Chaplan, Sandra R, Carruthers, Nicholas I
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Pharmacology and Antitussive Efficacy of 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic Acid (5-Trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a Transient Receptor Potential Vanilloid 1 Antagonist in Guinea Pigs
Bhattacharya, Anindya, Scott, Brian P, Nasser, Nadia, Ao, Hong, Maher, Michael P, Dubin, Adrienne E, Swanson, Devin M, Shankley, Nigel P, Wickenden, Alan D, Chaplan, Sandra R
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate
Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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Aplysamine-1 and related analogs as histamine H3 receptor antagonists
SWANSON, Devin M, WILSON, Sandy J, BOGGS, Jamin D, WEI XIAO, APODACA, Richard, BARBIER, Ann J, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Identification of (R)‑(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro‑1H‑imidazo[4,5‑c]pyridin-5(4H)‑yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor
Swanson, Devin M, Savall, Brad M, Coe, Kevin J, Schoetens, Freddy, Koudriakova, Tatiana, Skaptason, Judith, Wall, Jessica, Rech, Jason, Deng, Xiahou, De Angelis, Meri, Everson, Anita, Lord, Brian, Wang, Qi, Ao, Hong, Scott, Brian, Sepassi, Kia, Lovenberg, Timothy W, Carruthers, Nicholas I, Bhattacharya, Anindya, Letavic, Michael A
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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Discovery of Imidazo[1,2‑a]pyrazines and Pyrazolo[1,5‑c]pyrimidines as TARP γ‑8 Selective AMPAR Negative Modulators
Savall, Brad M, Wu, Dongpei, Swanson, Devin M, Seierstad, Mark, Wu, Nyantsz, Vives Martinez, Jorge, García Olmos, Beatriz, Lord, Brian, Coe, Kevin, Koudriakova, Tatiana, Lovenberg, Timothy W, Carruthers, Nicholas I, Maher, Michael P, Ameriks, Michael K
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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Lead Optimization of 5‑Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ‑8
Ravula, Suchitra, Savall, Brad M, Wu, Nyantsz, Lord, Brian, Coe, Kevin, Wang, Kai, Seierstad, Mark, Swanson, Devin M, Ziff, Jeannie, Nguyen, Minh, Leung, Perry, Rynberg, Ray, La, David, Pippel, Daniel J, Koudriakova, Tatiana, Lovenberg, Timothy W, Carruthers, Nicholas I, Maher, Michael P, Ameriks, Michael K
Published in ACS medicinal chemistry letters (09.08.2018)
Published in ACS medicinal chemistry letters (09.08.2018)
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In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor
Shoblock, James R., Welty, Natalie, Nepomuceno, Diane, Lord, Brian, Aluisio, Leah, Fraser, Ian, Motley, S. Timothy, Sutton, Steve W., Morton, Kirsten, Galici, Ruggero, Atack, John R., Dvorak, Lisa, Swanson, Devin M., Carruthers, Nicholas I., Dvorak, Curt, Lovenberg, Timothy W., Bonaventure, Pascal
Published in Psychopharmacology (01.02.2010)
Published in Psychopharmacology (01.02.2010)
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Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development
Letavic, Michael A, Aluisio, Leah, Apodaca, Richard, Bajpai, Manoj, Barbier, Ann J, Bonneville, Anne, Bonaventure, Pascal, Carruthers, Nicholas I, Dugovic, Christine, Fraser, Ian C, Kramer, Michelle L, Lord, Brian, Lovenberg, Timothy W, Li, Lilian Y, Ly, Kiev S, Mcallister, Heather, Mani, Neelakandha S, Morton, Kirsten L, Ndifor, Anthony, Nepomuceno, S. Diane, Pandit, Chennagiri R, Sands, Steven B, Shah, Chandra R, Shelton, Jonathan E, Snook, Sandra S, Swanson, Devin M, Xiao, Wei
Published in ACS medicinal chemistry letters (09.04.2015)
Published in ACS medicinal chemistry letters (09.04.2015)
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Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists
SWANSON, Devin M, SHAH, Chandra R, WILSON, Sandy J, BARBIER, Ann J, BONAVENTURE, Pascal, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, LORD, Brian, MORTON, Kirsten, DVORAK, Lisa K, MAZUR, Curt, APODACA, Richard, WEI XIAO, BOGGS, Jamin D, FEINSTEIN, Mark
Published in European journal of medicinal chemistry (01.11.2009)
Published in European journal of medicinal chemistry (01.11.2009)
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The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor
Swanson, Devin M., Wong, Victoria D., Jablonowski, Jill A., Shah, Chandra, Rudolph, Dale A., Dvorak, Curt A., Seierstad, Mark, Dvorak, Lisa K., Morton, Kirsten, Nepomuceno, Diane, Atack, John R., Bonaventure, Pascal, Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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AMPA AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS
CHEN GANG, JOURDAN FABRICE LOIC, AMERIKS MICHAEL K, LIN DAVID WEI, BERRY CYNTHIA G.B, RAVULA SUCHITRA, SAVALL BRADLEY M, SWANSON DEVIN M, PENA PINON MIGUEL ANGEL, WU DONGPEI, ZHANG WEI, LEBOLD TERRY PATRICK
Year of Publication 08.02.2024
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Year of Publication 08.02.2024
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P2X7 P2X7 MODULATORS
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Year of Publication 13.04.2023
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Year of Publication 13.04.2023
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P2X7 P2X7 MODULATORS
DENG XIAOHU, SAVALL BRAD M, ALCAZAR VACA MANUEL JESUS, ANDRES GIL JOSE IGNACIO, STENNE BRICE M, GELIN CHRISTINE F, DVORAK CURT A, SWANSON DEVIN M, COATE HEATHER R, DE ANGELIS MERI, SOYODEJOHNSON AKINOLA, ALLISON BRETT D, LETAVIC MICHAEL A, CHROVIAN CHRISTA C, LIANG JIMMY T, MANI NEELAKANDHA S, RECH JASON C, WALL JESSICA L
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Year of Publication 07.04.2022
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벤즈이미다졸론 및 벤조티아졸론 화합물 및 AMPA 수용체 조절제로서의 이들의 용도
AMERIKS MICHAEL K, RAVULA SUCHITRA, SWANSON DEVIN M, SAVALL BRADLEY M
Year of Publication 26.12.2017
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Year of Publication 26.12.2017
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인돌론 화합물 및 AMPA 수용체 조절제로서의 이의 용도
AMERIKS MICHAEL K, ZIFF JEANNIE M, RAVULA SUCHITRA, SAVALL BRADLEY M, SWANSON DEVIN M, SHIREMAN BROCK T
Year of Publication 26.12.2017
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Year of Publication 26.12.2017
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아자벤즈이미다졸 및 AMPA 수용체 조절제로서의 이의 용도
CHEN GANG, JOURDAN FABRICE LOIC, AMERIKS MICHAEL K, LIN DAVID WEI, BERRY CYNTHIA G.B, RAVULA SUCHITRA, SAVALL BRADLEY M, SWANSON DEVIN M, PENA PINON MIGUEL ANGEL, WU DONGPEI, ZHANG WEI, LEBOLD TERRY PATRICK
Year of Publication 20.12.2017
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Year of Publication 20.12.2017
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34- DISUBSTITUTED OCTAHYDROPYRROLO[34-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
SAVALL BRAD M, CHAI WENYING, SHAH CHANDRAVADAN R, LETAVIC MICHAEL A, LY KIEV S, PIPPEL DANIEL J, STOCKING EMILY M, SWANSON DEVIN M, RUDOLPH DALE A, STROTHER KATHLEEN C, SOYODE JOHNSON AKINOLA, SHIREMAN BROCK T
Year of Publication 11.12.2017
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Year of Publication 11.12.2017
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34- DISUBSTITUTED OCTAHYDROPYRROLO[34-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
SAVALL BRAD M, CHAI WENYING, SHAH CHANDRAVADAN R, LETAVIC MICHAEL A, LY KIEV S, PIPPEL DANIEL J, STOCKING EMILY M, SWANSON DEVIN M, RUDOLPH DALE A, STROTHER KATHLEEN C, SOYODE JOHNSON AKINOLA, SHIREMAN BROCK T
Year of Publication 08.12.2017
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Year of Publication 08.12.2017
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