The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers
Ryan, Meagan B., Quade, Bradley, Schenk, Natasha, Fang, Zhong, Zingg, Marshall, Cohen, Steven E., Swalm, Brooke M., Li, Chun, Özen, Ayşegül, Ye, Chaoyang, Ritorto, Maria Stella, Huang, Xin, Dar, Arvin C., Han, Yongxin, Hoeflich, Klaus P., Hale, Michael, Hagel, Margit
Published in Cancer discovery (01.07.2024)
Published in Cancer discovery (01.07.2024)
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The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer
Quiroz, Ryan V, Reutershan, Michael H, Schneider, Sebastian E, Sloman, David, Lacey, Brian M, Swalm, Brooke M, Yeung, Charles S, Gibeau, Craig, Spellman, Daniel S, Rankic, Danica A, Chen, Dapeng, Witter, David, Linn, Doug, Munsell, Erik, Feng, Guo, Xu, Haiyan, Hughes, Jonathan M. E, Lim, Jongwon, Saurí, Josep, Geddes, Kristin, Wan, Murray, Mansueto, My Sam, Follmer, Nicole E, Fier, Patrick S, Siliphaivanh, Phieng, Daublain, Pierre, Palte, Rachel L, Hayes, Robert P, Lee, Sandra, Kawamura, Shuhei, Silverman, Steven, Sanyal, Sulagna, Henderson, Timothy J, Ye, Yingchun, Gao, Yuanwei, Nicholson, Benjamin, Machacek, Michelle R
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Monitoring GAPDH activity and inhibition with cysteine-reactive chemical probes
Canarelli, Sarah E, Swalm, Brooke M, Larson, Eric T, Morrison, Michael J, Weerapana, Eranthie
Published in RSC chemical biology (06.07.2022)
Published in RSC chemical biology (06.07.2022)
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Reaction Coupling between Wild-Type and Disease-Associated Mutant EZH2
Swalm, Brooke M., Knutson, Sarah K., Warholic, Natalie M., Jin, Lei, Kuntz, Kevin W., Keilhack, Heike, Smith, Jesse J., Pollock, Roy M., Moyer, Mikel P., Scott, Margaret Porter, Copeland, Robert A., Wigle, Tim J.
Published in ACS chemical biology (21.11.2014)
Published in ACS chemical biology (21.11.2014)
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Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET
Swalm, Brooke M, Hallenbeck, Kenneth K, Majer, Christina R, Jin, Lei, Scott, Margaret Porter, Moyer, Mikel P, Copeland, Robert A, Wigle, Tim J
Published in Biochemical journal (15.07.2013)
Published in Biochemical journal (15.07.2013)
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The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers
Ryan, Meagan B, Quade, Bradley, Schenk, Natasha, Fang, Zhong, Zingg, Marshall, Cohen, Steven E, Swalm, Brooke M, Li, Chun, Ozen, Aysegul, Ye, Chaoyang, Ritorto, Maria Stella, Huang, Xin, Dar, Arvin C, Han, Yongxin, Hoeflich, Klaus P, Hale, Michael, Hagel, Margit
Published in Cancer discovery (08.04.2024)
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Published in Cancer discovery (08.04.2024)
Journal Article
Abstract ND10: NST-628 is a novel, potent, fully brain-penetrant MAPK pathway molecular glue that inhibits RAS- and RAF-driven cancers
Ryan, Meagan B., Quade, Bradley, Schenk, Natasha, Fang, Zhong, Zingg, Marshall, Cohen, Steven E., Li, Chun, Swalm, Brooke M., Ozen, Aysegul, Ye, Chaoyang, Ritorto, Maria Stella, Huang, Xin, Dar, Arvin C., Han, Yongxin, Hale, Michael, Hagel, Margit, Hoeflich, Klaus P.
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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