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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs
Bradley, Sophie J., Molloy, Colin, Valuskova, Paulina, Dwomoh, Louis, Scarpa, Miriam, Rossi, Mario, Finlayson, Lisa, Svensson, Kjell A., Chernet, Eyassu, Barth, Vanessa N., Gherbi, Karolina, Sykes, David A., Wilson, Caroline A., Mistry, Rajendra, Sexton, Patrick M., Christopoulos, Arthur, Mogg, Adrian J., Rosethorne, Elizabeth M., Sakata, Shuzo, John Challiss, R. A., Broad, Lisa M., Tobin, Andrew B.
Published in Nature chemical biology (01.03.2020)
Published in Nature chemical biology (01.03.2020)
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Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (–)-(1 R, 4 S,5 S,6 S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)
Fell, Matthew J., Svensson, Kjell A., Johnson, Bryan G., Schoepp, Darryle D.
Published in The Journal of pharmacology and experimental therapeutics (01.07.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2008)
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A chemogenetic approach for dopamine imaging with tunable sensitivity
Labouesse, Marie A., Wilhelm, Maria, Kagiampaki, Zacharoula, Yee, Andrew G., Denis, Raphaelle, Harada, Masaya, Gresch, Andrea, Marinescu, Alina-Măriuca, Otomo, Kanako, Curreli, Sebastiano, Serratosa Capdevila, Laia, Zhou, Xuehan, Cola, Reto B., Ravotto, Luca, Glück, Chaim, Cherepanov, Stanislav, Weber, Bruno, Zhou, Xin, Katner, Jason, Svensson, Kjell A., Fellin, Tommaso, Trudeau, Louis-Eric, Ford, Christopher P., Sych, Yaroslav, Patriarchi, Tommaso
Published in Nature communications (02.07.2024)
Published in Nature communications (02.07.2024)
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Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders
Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P., Hao, Junliang, Witkin, Jeffrey M., Li, Xia, Chernet, Eyassu, Katner, Jason S., Wang, Hong, Ryder, John W., Masquelin, Meghane E., Thompson, Linda K., Love, Patrick L., Maren, Deanna L., Falcone, Julie F., Menezes, Michelle M., Zhang, Linli, Yang, Charles R., Svensson, Kjell A.
Published in Neuropharmacology (01.01.2018)
Published in Neuropharmacology (01.01.2018)
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Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat
Swanson, Chad J., Perry, Kenneth W., Koch-Krueger, Susanne, Katner, Jason, Svensson, Kjell A., Bymaster, Frank P.
Published in Neuropharmacology (01.05.2006)
Published in Neuropharmacology (01.05.2006)
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Glutamatergic regulation of brain histamine neurons: In vivo microdialysis and electrophysiology studies in the rat
Fell, Matthew J., Flik, Gunnar, Dijkman, Ulrike, Folgering, Joost H.A., Perry, Kenneth W., Johnson, Bryan J., Westerink, Ben H.C., Svensson, Kjell A.
Published in Neuropharmacology (01.12.2015)
Published in Neuropharmacology (01.12.2015)
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Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior
Collins, Gregory T., Witkin, Jeffrey M., Newman, Amy H., Svensson, Kjell A., Grundt, Peter, Cao, Jianjing, Woods, James H.
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
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Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas
Perry, Kenneth W., Falcone, Julie F., Fell, Matthew J., Ryder, John W., Yu, Hong, Love, Patrick L., Katner, Jason, Gordon, Kimberly D., Wade, Mark R., Man, Teresa, Nomikos, George G., Phebus, Lee A., Cauvin, Annick J., Johnson, Kirk W., Jones, Carrie K., Hoffmann, Beth J., Sandusky, George E., Walter, Magnus W., Porter, Warren J., Yang, Lijuan, Merchant, Kalpana M., Shannon, Harlan E., Svensson, Kjell A.
Published in Neuropharmacology (01.10.2008)
Published in Neuropharmacology (01.10.2008)
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The Dopamine Stabilizers (S)-(-)-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-Methanesulfonylphenyl)-1-propyl-piperidine (ACR16) Show High in Vivo D2 Receptor Occupancy, Antipsychotic-Like Efficacy, and Low Potential for Motor Side Effects in the Rat
Natesan, Sridhar, Svensson, Kjell A., Reckless, Greg E., Nobrega, José N., Barlow, Karen B.L., Johansson, Anette M., Kapur, Shitij
Published in The Journal of pharmacology and experimental therapeutics (01.08.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2006)
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In Vitro and in Vivo Evidence for a Lack of Interaction with Dopamine D2 Receptors by the Metabotropic Glutamate 2/3 Receptor Agonists 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-bicaroxylate Monohydrate (LY354740) and (−)-2-Oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic Acid (LY379268)
Fell, Matthew J., Perry, Kenneth W., Falcone, Julie F., Johnson, Bryan G., Barth, Vanessa N., Rash, Karen S., Lucaites, Virginia L., Threlkeld, Penny G., Monn, James A., McKinzie, David L., Marek, Gerard J., Svensson, Kjell A., Nelson, David L.
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
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The dopamine D1 receptor positive allosteric modulator, DETQ, improves cognition and social interaction in aged mice and enhances cortical and hippocampal acetylcholine efflux
Rajagopal, Lakshmi, Huang, Mei, Mahjour, Sanaz, Ryan, Chelsea, Elzokaky, Ahmad, Svensson, Kjell A., Meltzer, H.Y.
Published in Behavioural brain research (29.02.2024)
Published in Behavioural brain research (29.02.2024)
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Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge
Fell, Matthew J., Katner, Jason S., Johnson, Bryan G., Khilevich, Albert, Schkeryantz, Jeffrey M., Perry, Kenneth W., Svensson, Kjell A.
Published in Neuropharmacology (01.03.2010)
Published in Neuropharmacology (01.03.2010)
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The allosteric dopamine D1 receptor potentiator, DETQ, ameliorates subchronic phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in male humanized D1 receptor knock-in mice
Meltzer, Herbert Y., Rajagopal, Lakshmi, Matrisciano, Francesco, Hao, Junliang, Svensson, Kjell A., Huang, Mei
Published in Behavioural brain research (01.04.2019)
Published in Behavioural brain research (01.04.2019)
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Modulation of neurotransmitter release in orexin/hypocretin-2 receptor knockout mice: A microdialysis study
Ortega, Jorge E., Katner, Jason, Davis, Richard, Wade, Mark, Nisenbaum, Laura, Nomikos, George G., Svensson, Kjell A., Perry, Kenneth W.
Published in Journal of neuroscience research (01.03.2012)
Published in Journal of neuroscience research (01.03.2012)
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Mutual Cooperativity of Three Allosteric Sites on the Dopamine D1 Receptor
Wang, Xushan, Hembre, Erik J., Goldsmith, Paul J., Beck, James P., Svensson, Kjell A., Willard, Francis S., Bruns, Robert F.
Published in Molecular pharmacology (01.03.2023)
Published in Molecular pharmacology (01.03.2023)
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The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers
McCarthy, Andrew P., Svensson, Kjell A., Shanks, Elaine, Brittain, Claire, Eastwood, Brian J., Kielbasa, William, Biglan, Kevin M., Wafford, Keith A.
Published in The Journal of pharmacology and experimental therapeutics (01.03.2022)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2022)
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Ensemble Docking Approach to Mitigate Pregnane X Receptor-Mediated CYP3A4 Induction Risk
Chen, Qi, Zhou, Xin, Rehmel, Jessica, Steele, James P., Svensson, Kjell A., Beck, James P., Hembre, Erik J., Hao, Junliang
Published in Journal of chemical information and modeling (09.01.2023)
Published in Journal of chemical information and modeling (09.01.2023)
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