ΔFosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer’s Disease
Corbett, Brian F., You, Jason C., Zhang, Xiaohong, Pyfer, Mark S., Tosi, Umberto, Iascone, Daniel M., Petrof, Iraklis, Hazra, Anupam, Fu, Chia-Hsuan, Stephens, Gabriel S., Ashok, Annie A., Aschmies, Suzan, Zhao, Lijuan, Nestler, Eric J., Chin, Jeannie
Published in Cell reports (Cambridge) (11.07.2017)
Published in Cell reports (Cambridge) (11.07.2017)
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Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels
Riddell, David R, Zhou, Hua, Atchison, Kevin, Warwick, Helen K, Atkinson, Peter J, Jefferson, Julius, Xu, Lin, Aschmies, Suzan, Kirksey, Yolanda, Hu, Yun, Wagner, Erik, Parratt, Adrienne, Xu, Jane, Li, Zhuting, Zaleska, Margaret M, Jacobsen, J. Steve, Pangalos, Menelas N, Reinhart, Peter H
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Published in The Journal of neuroscience (05.11.2008)
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The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
Riddell, David R., Zhou, Hua, Comery, Thomas A., Kouranova, Evguenia, Lo, C. Frederick, Warwick, Helen K., Ring, Robert H., Kirksey, Yolanda, Aschmies, Suzan, Xu, Jane, Kubek, Katie, Hirst, Warren D., Gonzales, Catherine, Chen, Yi, Murphy, Erin, Leonard, Sarah, Vasylyev, Dmytro, Oganesian, Aram, Martone, Robert L., Pangalos, Menelas N., Reinhart, Peter H., Jacobsen, J. Steve
Published in Molecular and cellular neuroscience (01.04.2007)
Published in Molecular and cellular neuroscience (01.04.2007)
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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade
Jacobsen, J. Steven, Comery, Thomas A, Martone, Robert L, Elokdah, Hassan, Crandall, David L, Oganesian, Aram, Aschmies, Suzan, Kirksey, Yolanda, Gonzales, Cathleen, Xu, Jane, Zhou, Hua, Atchison, Kevin, Wagner, Erik, Zaleska, Margaret M, Das, Indranil, Arias, Robert L, Bard, Jonathan, Riddell, David, Gardell, Stephen J, Abou-Gharbia, Magid, Robichaud, Albert, Magolda, Ronald, Vlasuk, George P, Bjornsson, Thorir, Reinhart, Peter H, Pangalos, Menelas N
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2008)
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Correlating Efficacy in Rodent Cognition Models with in Vivo 5-Hydroxytryptamine1A Receptor Occupancy by a Novel Antagonist, (R)-N-(2-Methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane Carboxamide (WAY-101405)
Hirst, Warren D, Andree, Terrance H, Aschmies, Suzan, Childers, Wayne E, Comery, Thomas A, Dawson, Lee A, Day, Mark, Feingold, Irene B, Grauer, Steven M, Harrison, Boyd L, Hughes, Zoë A, Kao, John, Kelly, Michael G, van der Lee, Heidi, Rosenzweig-Lipson, Sharon, Saab, Annmarie L, Smith, Deborah L, Sullivan, Kelly, Rizzo, Stacey J Sukoff, Tio, Cesario, Zhang, Mei-Yi, Schechter, Lee E
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
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( S) -N-(5-Chlorothiophene-2-sulfonyl)-β,β-diethylalaninol a Notch-1-sparing γ-secretase inhibitor
Cole, Derek C., Stock, Joseph R., Kreft, Anthony F., Antane, Madelene, Aschmies, Suzan H., Atchison, Kevin P., Casebier, David S., Comery, Thomas A., Diamantidis, George, Ellingboe, John W., Harrison, Boyd L., Hu, Yun, Jin, Mei, Kubrak, Dennis M., Lu, Peimin, Mann, Charles W., Martone, Robert L., Moore, William J., Oganesian, Aram, Riddell, David R., Sonnenberg-Reines, June, Sun, Shaiu-Ching, Wagner, Erik, Wang, Zheng, Woller, Kevin R., Xu, Zheng, Zhou, Hua, Jacobsen, J. Steven
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Synthesis and structure–activity relationship of a novel series of heterocyclic sulfonamide γ-secretase inhibitors
Pu, Jun, Kreft, Anthony F., Aschmies, Suzan H., Atchison, Kevin P., Berkowitz, Joshua, Caggiano, Thomas J., Chlenov, Micheal, Diamantidis, George, Harrison, Boyd L., Hu, Yun, Huryn, Donna, Steven Jacobsen, J., Jin, Mei, Lipinski, Kerri, Lu, Peimin, Martone, Robert L., Morris, Koi, Sonnenberg-Reines, June, Riddell, Dave R., Sabalski, Joan, Sun, Shaiu-Ching, Wagner, Erik, Wang, Yiqun, Xu, Zheng, Zhou, Hua, Resnick, Lynn
Published in Bioorganic & medicinal chemistry (01.07.2009)
Published in Bioorganic & medicinal chemistry (01.07.2009)
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2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one Derivatives as Potent and Selective Histamine-3 Receptor Antagonists
Zhou, Dahui, Gross, Jonathan L, Adedoyin, Adedayo B, Aschmies, Suzan B, Brennan, Julie, Bowlby, Mark, Di, Li, Kubek, Katie, Platt, Brian J, Wang, Zheng, Zhang, Guoming, Brandon, Nicholas, Comery, Thomas A, Robichaud, Albert J
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer’s disease
Hazra, Anupam, Corbett, Brian F, You, Jason C, Aschmies, Suzan, Zhao, Lijuan, Li, Ke, Lepore, Angelo C, Marsh, Eric D, Chin, Jeannie
Published in Neurobiology of aging (01.08.2016)
Published in Neurobiology of aging (01.08.2016)
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Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease
Martone, Robert L, Zhou, Hua, Atchison, Kevin, Comery, Thomas, Xu, Jane Z, Huang, Xinyi, Gong, Xioahai, Jin, Mei, Kreft, Anthony, Harrison, Boyd, Mayer, Scott C, Aschmies, Suzan, Gonzales, Cathleen, Zaleska, Margaret M, Riddell, David R, Wagner, Erik, Lu, Peimin, Sun, Shaiu-Ching, Sonnenberg-Reines, June, Oganesian, Aram, Adkins, Karissa, Leach, Michael W, Clarke, David W, Huryn, Donna, Abou-Gharbia, Magid, Magolda, Ronald, Bard, Jonathan, Frick, Glen, Raje, Sangeeta, Forlow, S Bradley, Balliet, Carrie, Burczynski, Michael E, Reinhart, Peter H, Wan, Hong I, Pangalos, Menelas N, Jacobsen, J Steven
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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The LXR agonist TO901317 selectively lowers hippocampal A beta 42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
Riddell, DR, Zhou, H, Comery, T A, Kouranova, E, Lo, C F, Warwick, H K, Ring, R H, Kirksey, Y, Aschmies, S, Xu, J, Kubek, K, Hirst, W D, Gonzales, C, Chen, Y, Murphy, E, Leonard, S, Vasylyev, D, Oganesian, A, Martone, R L, Pangalos, M N, Reinhart, PH, Jacobsen, J S
Published in Molecular and cellular neuroscience (01.04.2007)
Published in Molecular and cellular neuroscience (01.04.2007)
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Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease
Comery, Thomas A, Martone, Robert L, Aschmies, Suzan, Atchison, Kevin P, Diamantidis, George, Gong, Xiaohai, Zhou, Hua, Kreft, Anthony F, Pangalos, Menelas N, Sonnenberg-Reines, June, Jacobsen, J Steven, Marquis, Karen L
Published in The Journal of neuroscience (28.09.2005)
Published in The Journal of neuroscience (28.09.2005)
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Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease
Mayer, Scott C, Kreft, Anthony F, Harrison, Boyd, Abou-Gharbia, Magid, Antane, Madelene, Aschmies, Suzan, Atchison, Kevin, Chlenov, Michael, Cole, Derek C, Comery, Thomas, Diamantidis, George, Ellingboe, John, Fan, Kristi, Galante, Rocco, Gonzales, Cathleen, Ho, Douglas M, Hoke, Molly E, Hu, Yun, Huryn, Donna, Jain, Uday, Jin, Mei, Kremer, Kenneth, Kubrak, Dennis, Lin, Melissa, Lu, Peimin, Magolda, Ron, Martone, Robert, Moore, William, Oganesian, Aram, Pangalos, Menelas N, Porte, Alex, Reinhart, Peter, Resnick, Lynn, Riddell, David R, Sonnenberg-Reines, June, Stock, Joseph R, Sun, Shaiu-Ching, Wagner, Erik, Wang, Ting, Woller, Kevin, Xu, Zheng, Zaleska, Margaret M, Zeldis, Joseph, Zhang, Minsheng, Zhou, Hua, Jacobsen, J. Steven
Published in Journal of medicinal chemistry (11.12.2008)
Published in Journal of medicinal chemistry (11.12.2008)
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Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)
Ghiron, Chiara, Haydar, Simon N, Aschmies, Suzan, Bothmann, Hendrick, Castaldo, Cristiana, Cocconcelli, Giuseppe, Comery, Thomas A, Di, Li, Dunlop, John, Lock, Tim, Kramer, Angela, Kowal, Dianne, Jow, Flora, Grauer, Steve, Harrison, Boyd, La Rosa, Salvatore, Maccari, Laura, Marquis, Karen L, Micco, Iolanda, Nencini, Arianna, Quinn, Joanna, Robichaud, Albert J, Roncarati, Renza, Scali, Carla, Terstappen, Georg C, Turlizzi, Elisa, Valacchi, Michela, Varrone, Maurizio, Zanaletti, Riccardo, Zanelli, Ugo
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT6 Receptor Antagonists
Haydar, Simon N, Yun, Heedong, Andrae, Patrick M, Mattes, James, Zhang, Jean, Kramer, Angela, Smith, Deborah L, Huselton, Christine, Graf, Radka, Aschmies, Suzan, Schechter, Lee E, Comery, Thomas A, Robichaud, Albert J
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Benzimidazole- and indole-substituted 1,3′-bipyrrolidine benzamides as histamine H 3 receptor antagonists
Cole, Derek C., Gross, Jonathan L., Comery, Thomas A., Aschmies, Suzan, Hirst, Warren D., Kelley, Cody, Kim, Ji-In, Kubek, Katie, Ning, Xiaoping, Platt, Brian J., Robichaud, Albert J., Solvibile, William R., Stock, Joseph R., Tawa, Gregory, Williams, Marla J., Ellingboe, John W.
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT 6 Receptor Antagonists
Haydar, Simon N., Yun, Heedong, Andrae, Patrick M., Mattes, James, Zhang, Jean, Kramer, Angela, Smith, Deborah L., Huselton, Christine, Graf, Radka, Aschmies, Suzan, Schechter, Lee E., Comery, Thomas A., Robichaud, Albert J.
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Journal Article
Discovery of a novel series of Notch-sparing γ-secretase inhibitors
Kreft, Anthony, Harrison, Boyd, Aschmies, Suzan, Atchison, Kevin, Casebier, David, Cole, Derek C., Diamantidis, George, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Lundquist, Joseph, Mann, Charles, Martone, Robert, Moore, William, Oganesian, Aram, Porte, Alex, Riddell, Dave R., Sonnenberg-Reines, June, Stock, Joseph R., Sun, Shaiu-Ching, Wagner, Erik, Woller, Kevin, Xu, Zheng, Zhou, Hua, Steven Jacobsen, J.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Journal Article
Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists
COLE, Derek C, GROSS, Jonathan L, ROBICHAUD, Albert J, SOLVIBILE, William R, STOCK, Joseph R, TAWA, Gregory, WILLIAMS, Marla J, ELLINGBOE, John W, COMERY, Thomas A, ASCHMIES, Suzan, HIRST, Warren D, KELLEY, Cody, KIM, Ji-In, KUBEK, Katie, XIAOPING NING, PLATT, Brian J
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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PRE-CLINICAL CHARACTERIZATION OF THE ALPHA-7 NICOTINIC RECEPTOR AGONIST SEN12333/WAY-317538
Comery, Thomas, Scali, Carla, Haydar, Simon, Roncarati, Renza, Ghiron, Chiara, Dunlop, John, Aschmies, Suzan, Bothmann, Hendrick, Graf, Radka, Gianfriddo, Marco, Grauer, Steven, Jow, Brian, Kelley, Cody, Terstappen, Georg
Published in Schizophrenia research (2008)
Published in Schizophrenia research (2008)
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