Beyond target cell death – Granzyme serine proteases in health and disease
Nüssing, Simone, Sutton, Vivien R., Trapani, Joseph A., Parish, Ian A.
Published in Molecular aspects of medicine (01.12.2022)
Published in Molecular aspects of medicine (01.12.2022)
Get full text
Journal Article
Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity
Spicer, Julie A., Huttunen, Kristiina M., Jose, Jiney, Dimitrov, Ivo, Akhlaghi, Hedieh, Sutton, Vivien R., Voskoboinik, Ilia, Trapani, Joseph
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
Get full text
Journal Article
Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1
Castiblanco, Daniela, Rudd-Schmidt, Jesse A., Noori, Tahereh, Sutton, Vivien R., Hung, Ya Hui, Flinsenberg, Thijs W.H., Hodel, Adrian W., Young, Neil D., Smith, Nicholas, Bratkovic, Drago, Peters, Heidi, Walterfang, Mark, Trapani, Joseph A., Brennan, Amelia J., Voskoboinik, Ilia
Published in Blood (24.03.2022)
Published in Blood (24.03.2022)
Get full text
Journal Article
Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells
Sutton, Vivien R., Watt, Sally V., Akhlaghi, Hedieh, Cipolla, David C., Chen, Kuan-Ju, LaSala, Daniel, McDonald, Patrick P., Beavis, Paul A., Munoz, Isabelle, Hodel, Adrian W., Noori, Tahereh, Voskoboinik, Ilia, Trapani, Joseph A.
Published in Frontiers in pharmacology (03.07.2024)
Published in Frontiers in pharmacology (03.07.2024)
Get full text
Journal Article
Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity
Sutton, Vivien R., Brennan, Amelia J., Ellis, Sarah, Danne, Jill, Thia, Kevin, Jenkins, Misty R., Voskoboinik, Ilia, Pejler, Gunnar, Johnstone, Ricky W., Andrews, Daniel M., Trapani, Joseph A.
Published in The FEBS journal (01.03.2016)
Published in The FEBS journal (01.03.2016)
Get full text
Journal Article
Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus
Sutton, Vivien R., Andoniou, Christopher, Leeming, Michael G., House, Colin M., Watt, Sally V., Verschoor, Sandra, Ciccone, Annette, Voskoboinik, Ilia, Degli-Esposti, Mariapia, Trapani, Joseph A.
Published in Biochimica et biophysica acta. Proteins and proteomics (01.09.2020)
Published in Biochimica et biophysica acta. Proteins and proteomics (01.09.2020)
Get full text
Journal Article
Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction
Fujihara, Kenji M., Zhang, Bonnie Z., Jackson, Thomas D., Ogunkola, Moses O., Nijagal, Brunda, Milne, Julia V., Sallman, David A., Ang, Ching-Seng, Nikolic, Iva, Kearney, Conor J., Hogg, Simon J., Cabalag, Carlos S., Sutton, Vivien R., Watt, Sally, Fujihara, Asuka T., Trapani, Joseph A., Simpson, Kaylene J., Stojanovski, Diana, Leimkühler, Silke, Haupt, Sue, Phillips, Wayne A., Clemons, Nicholas J.
Published in Science advances (16.09.2022)
Published in Science advances (16.09.2022)
Get full text
Journal Article
A natural genetic variant of granzyme B confers lethality to a common viral infection
Andoniou, Christopher E, Sutton, Vivien R, Wikstrom, Matthew E, Fleming, Peter, Thia, Kevin Y T, Matthews, Antony Y, Kaiserman, Dion, Schuster, Iona S, Coudert, Jerome D, Eldi, Preethi, Chaudhri, Geeta, Karupiah, Gunasegaran, Bird, Phillip I, Trapani, Joseph A, Degli-Esposti, Mariapia A
Published in PLoS pathogens (01.12.2014)
Published in PLoS pathogens (01.12.2014)
Get full text
Journal Article
Antigen‐specific CD4+CD25+ T cells induced by locally expressed ICOS‐Ig: the role of Foxp3, Perforin, Granzyme B and IL‐10 ‐ an experimental study
Christiansen, Dale, Mouhtouris, Effie, Hodgson, Russell, Sutton, Vivien R., Trapani, Joseph A., Ierino, Francesco L., Sandrin, Mauro S.
Published in Transplant international (01.11.2019)
Published in Transplant international (01.11.2019)
Get full text
Journal Article
Cathepsin H Is an Additional Convertase of Pro-granzyme B
D'Angelo, Michael E., Bird, Phillip I., Peters, Christoph, Reinheckel, Thomas, Trapani, Joseph A., Sutton, Vivien R.
Published in The Journal of biological chemistry (02.07.2010)
Published in The Journal of biological chemistry (02.07.2010)
Get full text
Journal Article
Activated mouse B cells lack expression of granzyme B
Hagn, Magdalena, Belz, Gabrielle T, Kallies, Axel, Sutton, Vivien R, Thia, Kevin Y, Tarlinton, David M, Hawkins, Edwin D, Trapani, Joseph A
Published in The Journal of immunology (1950) (15.04.2012)
Published in The Journal of immunology (1950) (15.04.2012)
Get full text
Journal Article
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L
Konjar, Špela, Sutton, Vivien R, Hoves, Sabine, Repnik, Urška, Yagita, Hideo, Reinheckel, Thomas, Peters, Christoph, Turk, Vito, Turk, Boris, Trapani, Joseph A, Kopitar-Jerala, Nataša
Published in Immunology (01.10.2010)
Published in Immunology (01.10.2010)
Get full text
Journal Article
Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function
Voskoboinik, Ilia, Sutton, Vivien R., Ciccone, Annette, House, Colin M., Chia, Jenny, Darcy, Phillip K., Yagita, Hideo, Trapani, Joseph A.
Published in Blood (15.08.2007)
Published in Blood (15.08.2007)
Get full text
Journal Article
ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
Cheong, Melody, Gartlan, Kate H, Lee, Jason S, Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D, Andoniou, Christopher E, Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R, Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A, Boyle, Glen M, Smyth, Mark J, Engwerda, Christian R, MacDonald, Kelli P A, Trapani, Joseph A, Degli-Esposti, Mariapia A, Koyama, Motoko, Hill, Geoffrey R
Published in Cancer immunology research (01.08.2020)
Published in Cancer immunology research (01.08.2020)
Get more information
Journal Article
The Drug Efflux Protein, P-Glycoprotein, Additionally Protects Drug-Resistant Tumor Cells from Multiple Forms of Caspase-Dependent Apoptosis
Smyth, Mark J., Krasovskis, Erika, Sutton, Vivien R., Johnstone, Ricky W.
Published in Proceedings of the National Academy of Sciences - PNAS (09.06.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (09.06.1998)
Get full text
Journal Article
Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors
Gartlan, Kate H., Jaiswal, Jagdish K., Bull, Matthew R., Akhlaghi, Hedieh, Sutton, Vivien R., Alexander, Kylie A., Chang, Karshing, Hill, Geoffrey R., Miller, Christian K., O’Connor, Patrick D., Jose, Jiney, Trapani, Joseph A., Charman, Susan A., Spicer, Julie A., Jamieson, Stephen M. F.
Published in ACS pharmacology & translational science (10.06.2022)
Published in ACS pharmacology & translational science (10.06.2022)
Get full text
Journal Article