Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner
Rao, Yi, Gammon, Seth T., Sutton, Margie N., Zacharias, Niki M., Bhattacharya, Pratip, Piwnica-Worms, David
Published in The Journal of biological chemistry (01.07.2021)
Published in The Journal of biological chemistry (01.07.2021)
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Journal Article
DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters
Sutton, Margie N., Lu, Zhen, Li, Yao-Cheng, Zhou, Yong, Huang, Tao, Reger, Albert S., Hurwitz, Amy M., Palzkill, Timothy, Logsdon, Craig, Liang, Xiaowen, Gray, Joe W., Nan, Xiaolin, Hancock, John, Wahl, Geoffrey M., Bast, Robert C.
Published in Cell reports (Cambridge) (10.12.2019)
Published in Cell reports (Cambridge) (10.12.2019)
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Journal Article
The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3‐induced dormant ovarian cancer xenografts
Mao, Weiqun, Peters, Haley L., Sutton, Margie N., Orozco, Aaron F., Pang, Lan, Yang, Hailing, Lu, Zhen, Bast, Robert C.
Published in Cancer (15.04.2019)
Published in Cancer (15.04.2019)
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Journal Article
Directed evolution of cyclic peptides for inhibition of autophagy
Gray, Joshua P, Uddin, Md. Nasir, Chaudhari, Rajan, Sutton, Margie N, Yang, Hailing, Rask, Philip, Locke, Hannah, Engel, Brian J, Batistatou, Nefeli, Wang, Jing, Grindel, Brian J, Bhattacharya, Pratip, Gammon, Seth T, Zhang, Shuxing, Piwnica-Worms, David, Kritzer, Joshua A, Lu, Zhen, Bast, Robert C, Millward, Steven W
Published in Chemical science (Cambridge) (13.01.2021)
Published in Chemical science (Cambridge) (13.01.2021)
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Journal Article
Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders
Li, Yao-Cheng, 李燿成, Lytle, Nikki K., Gammon, Seth T., Wang, Luke, Hayes, Tikvah K., Sutton, Margie N., Bast, Robert C., Der, Channing J., Piwnica-Worms, David, McCormick, Frank, Wahl, Geoffrey M.
Published in Proceedings of the National Academy of Sciences - PNAS (02.06.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (02.06.2020)
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Journal Article
RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells
Sutton, Margie N., Yang, Hailing, Huang, Gilbert Y., Fu, Caroline, Pontikos, Michael, Wang, Yan, Mao, Weiqun, Pang, Lan, Yang, Maojie, Liu, Jinsong, Parker-Thornburg, Jan, Lu, Zhen, Bast, Robert C.
Published in Autophagy (03.04.2018)
Published in Autophagy (03.04.2018)
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Journal Article
RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging
Sutton, Margie N., Gammon, Seth T., Muzzioli, Riccardo, Pisaneschi, Federica, Radaram, Bhasker, Yang, Ping, Piwnica-Worms, David
Published in Molecular imaging and biology (01.06.2022)
Published in Molecular imaging and biology (01.06.2022)
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Journal Article
Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging
Engel, Brian J, Paolillo, Vincenzo, Uddin, Md Nasir, Gonzales, Kristyn A, McGinnis, Kathryn M, Sutton, Margie N, Patnana, Madhavi, Grindel, Brian J, Gores, Gregory J, Piwnica-Worms, David, Beretta, Laura, Pisaneschi, Federica, Gammon, Seth T, Millward, Steven W
Published in Cancers (26.07.2023)
Published in Cancers (26.07.2023)
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Journal Article
Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression
Sutton, Margie N, Huang, Gilbert Y, Zhou, Jinhua, Mao, Weiqun, Langley, Robert, Lu, Zhen, Bast, Jr, Robert C
Published in Cancers (30.04.2019)
Published in Cancers (30.04.2019)
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Journal Article
Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB
Morgado, Micaela, Sutton, Margie N, Simmons, Mary, Warren, Curtis R, Lu, Zhen, Constantinou, Pamela E, Liu, Jinsong, Francis, Lewis L W, Conlan, R Steven, Bast, Jr, Robert C, Carson, Daniel D
Published in Oncotarget (22.03.2016)
Published in Oncotarget (22.03.2016)
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Journal Article
Complementary Longitudinal Serum Biomarkers to CA125 for Early Detection of Ovarian Cancer
Simmons, Archana R, Fourkala, Evangelia Ourania, Gentry-Maharaj, Aleksandra, Ryan, Andy, Sutton, Margie N, Baggerly, Keith, Zheng, Hui, Lu, Karen H, Jacobs, Ian, Skates, Steven, Menon, Usha, Bast, Jr, Robert C
Published in Cancer prevention research (Philadelphia, Pa.) (01.06.2019)
Published in Cancer prevention research (Philadelphia, Pa.) (01.06.2019)
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Journal Article
Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models
Ornelas, Argentina, McCullough, Christopher R, Lu, Zhen, Zacharias, Niki M, Kelderhouse, Lindsay E, Gray, Joshua, Yang, Hailing, Engel, Brian J, Wang, Yan, Mao, Weiqun, Sutton, Margie N, Bhattacharya, Pratip K, Bast, Jr, Robert C, Millward, Steven W
Published in BMC cancer (26.10.2016)
Published in BMC cancer (26.10.2016)
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Journal Article
Abstract 3659: DIRAS1 and DIRAS2 are novel ovarian cancer tumor suppressors that regulate cell growth, motility and autophagy
Sutton, Margie N., Lu, Zhen, Yang, Hailing, Huang, Gilbert, Wang, Yan, Mao, Weiqun, Bast, Robert C.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1
Sutton, Margie N, Huang, Gilbert Y, Liang, Xiaowen, Sharma, Rajesh, Reger, Albert S, Mao, Weiqun, Pang, Lan, Rask, Philip J, Lee, Kwangkook, Gray, Joshua P, Hurwitz, Amy M, Palzkill, Timothy, Millward, Steven W, Kim, Choel, Lu, Zhen, Bast, Jr, Robert C
Published in Cancers (18.04.2019)
Published in Cancers (18.04.2019)
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Journal Article
Synthesis and Characterization of Radio-Halogenated Talazoparib Analogues for Radioligand Therapy Applications
Muzzioli, Riccardo, Pisaneschi, Federica, Gammon, Seth, Sutton, Margie, Napoli, Arianna, McIntosh, Lauren, Tereshatov, Evgeny, Tabacaru, Gabriel, Schultz, Steven, McCann, Laura, Burns, Jonathan, Yennello, Sherry, Piwnica-Worms, David
Published in Nuclear medicine and biology (01.11.2023)
Published in Nuclear medicine and biology (01.11.2023)
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