Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis
Sutherland, Hamish S., Lu, Guo-Liang, Tong, Amy S.T., Conole, Daniel, Franzblau, Scott G., Upton, Anna M., Lotlikar, Manisha U., Cooper, Christopher B., Palmer, Brian D., Choi, Peter J., Denny, William A.
Published in European journal of medicinal chemistry (05.02.2022)
Published in European journal of medicinal chemistry (05.02.2022)
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Journal Article
Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline
Choi, Peter J, Conole, Daniel, Sutherland, Hamish S, Blaser, Adrian, Tong, Amy S T, Cooper, Christopher B, Upton, Anna M, Palmer, Brian D, Denny, William A
Published in Molecules (Basel, Switzerland) (20.03.2020)
Published in Molecules (Basel, Switzerland) (20.03.2020)
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Journal Article
Synthesis and Structure–Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-N-(Pyridin-2-ylmethyl)Pyrazolo[1,5-a]Pyrimidin-7-Amines
Sutherland, Hamish S., Choi, Peter J., Lu, Guo-Liang, Giddens, Anna C., Tong, Amy S. T., Franzblau, Scott G., Cooper, Christopher B., Palmer, Brian D., Denny, William A.
Published in Pharmaceuticals (Basel, Switzerland) (08.09.2022)
Published in Pharmaceuticals (Basel, Switzerland) (08.09.2022)
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Journal Article
3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel
Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Blaser, Adrian, Conole, Daniel, Franzblau, Scott G., Lotlikar, Manisha U., Cooper, Christopher B., Upton, Anna M., Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.04.2019)
Published in Bioorganic & medicinal chemistry (01.04.2019)
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Journal Article
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles
Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha U., Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
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Journal Article
Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline
Blaser, Adrian, Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha, Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.04.2019)
Published in Bioorganic & medicinal chemistry (01.04.2019)
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Journal Article
Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology
Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha, Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
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Journal Article
Synthetic studies towards isomeric pyrazolopyrimidines as potential ATP synthesis inhibitors of Mycobacterium tuberculosis. Structural correction of reported N-(6-(2-(dimethylamino)ethoxy)-5-fluoropyridin-3-yl)-2-(4-fluorophenyl)-5-(trifluoromethyl)pyrazolo[1,5-α]pyrimidin-7-amine
Choi, Peter J., Lu, Guo-Liang, Sutherland, Hamish S., Giddens, Anna C., Franzblau, Scott G., Cooper, Christopher B., Denny, William A., Palmer, Brian D.
Published in Tetrahedron letters (02.02.2022)
Published in Tetrahedron letters (02.02.2022)
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Journal Article
Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units
Choi, Peter J., Sutherland, Hamish S., Tong, Amy S.T., Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Lotlikar, Manisha U., Upton, Anna M., Guillemont, Jerome, Motte, Magali, Queguiner, Laurence, Andries, Koen, Van den Broeck, Walter, Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis
Lu, Guo-Liang, Tong, Amy S.T., Conole, Daniel, Sutherland, Hamish S., Choi, Peter J., Franzblau, Scott G., Upton, Anna M., Lotlikar, Manisha U., Cooper, Christopher B., Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (15.11.2020)
Published in Bioorganic & medicinal chemistry (15.11.2020)
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Journal Article
Synthesis and Structure−Activity Studies of Biphenyl Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
Palmer, Brian D, Thompson, Andrew M, Sutherland, Hamish S, Blaser, Adrian, Kmentova, Iveta, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Denny, William A
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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Journal Article
6‑Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis
Tong, Amy S. T, Choi, Peter J, Blaser, Adrian, Sutherland, Hamish S, Tsang, Sophia K. Y, Guillemont, Jerome, Motte, Magali, Cooper, Christopher B, Andries, Koen, Van den Broeck, Walter, Franzblau, Scott G, Upton, Anna M, Denny, William A, Palmer, Brian D, Conole, Daniel
Published in ACS medicinal chemistry letters (12.10.2017)
Published in ACS medicinal chemistry letters (12.10.2017)
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Journal Article
Synthesis and Structure−Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
Kmentova, Iveta, Sutherland, Hamish S, Palmer, Brian D, Blaser, Adrian, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Denny, William A, Thompson, Andrew M
Published in Journal of medicinal chemistry (09.12.2010)
Published in Journal of medicinal chemistry (09.12.2010)
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Journal Article
Synthesis and Structure–Activity Relationships of Varied Ether Linker Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
Thompson, Andrew M, Sutherland, Hamish S, Palmer, Brian D, Kmentova, Iveta, Blaser, Adrian, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Denny, William A
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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Journal Article
Synthesis and Structure−activity Relationships of Antitubercular 2-Nitroimidazooxazines Bearing Heterocyclic Side Chains
Sutherland, Hamish S, Blaser, Adrian, Kmentova, Iveta, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Palmer, Brian D, Denny, William A, Thompson, Andrew M
Published in Journal of medicinal chemistry (28.01.2010)
Published in Journal of medicinal chemistry (28.01.2010)
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Journal Article
Structure–Activity Relationships for Amide-, Carbamate-, And Urea-Linked Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
Blaser, Adrian, Palmer, Brian D, Sutherland, Hamish S, Kmentova, Iveta, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Thompson, Andrew M, Denny, William A
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
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Journal Article
Therapeutic reactivation of mutant p53 protein by quinazoline derivatives
Sutherland, Hamish S., Hwang, In Young, Marshall, Elaine S., Lindsay, Brent S., Denny, William A., Gilchrist, Catherine, Joseph, Wayne R., Greenhalgh, Debra, Richardson, Emma, Kestell, Philip, Ding, Angela, Baguley, Bruce C.
Published in Investigational new drugs (01.10.2012)
Published in Investigational new drugs (01.10.2012)
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Journal Article
Insertion reactions of alkenes with diterpenoid chromium aminocarbenes
Woodgate, Paul D, Sutherland, Hamish S
Published in Journal of organometallic chemistry (26.05.2001)
Published in Journal of organometallic chemistry (26.05.2001)
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Journal Article