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de Groot, Marcel J, Kirton, Stewart B, Sutcliffe, Michael J
Published in Current topics in medicinal chemistry (01.01.2004)
Published in Current topics in medicinal chemistry (01.01.2004)
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Atomic Description of an Enzyme Reaction Dominated by Proton Tunneling
Masgrau, Laura, Roujeinikova, Anna, Johannissen, Linus O, Hothi, Parvinder, Basran, Jaswir, Ranaghan, Kara E, Mulholland, Adrian J, Sutcliffe, Michael J, Scrutton, Nigel S, Leys, David
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High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children's Oncology Group (COG) initiative
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Extensive conformational sampling in a ternary electron transfer complex
Leys, David, Basran, Jaswir, Talfournier, François, Sutcliffe, Michael J, Scrutton, Nigel S
Published in Nature structural & molecular biology (01.03.2003)
Published in Nature structural & molecular biology (01.03.2003)
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Enzymatic H-Transfer Requires Vibration-Driven Extreme Tunneling
Basran, Jaswir, Sutcliffe, Michael J, Scrutton, Nigel S
Published in Biochemistry (Easton) (09.03.1999)
Published in Biochemistry (Easton) (09.03.1999)
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Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs
Perry, Matthew, Stansfeld, Phillip J, Leaney, Joanne, Wood, Claire, de Groot, Marcel J, Leishman, Derek, Sutcliffe, Michael J, Mitcheson, John S
Published in Molecular pharmacology (01.02.2006)
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Importance of barrier shape in enzyme-catalyzed reactions. Vibrationally assisted hydrogen tunneling in tryptophan tryptophylquinone-dependent amine dehydrogenases
Basran, J, Patel, S, Sutcliffe, M J, Scrutton, N S
Published in The Journal of biological chemistry (02.03.2001)
Published in The Journal of biological chemistry (02.03.2001)
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H-tunneling in the Multiple H-transfers of the Catalytic Cycle of Morphinone Reductase and in the Reductive Half-reaction of the Homologous Pentaerythritol Tetranitrate Reductase
Basran, Jaswir, Harris, Richard J., Sutcliffe, Michael J., Scrutton, Nigel S.
Published in The Journal of biological chemistry (07.11.2003)
Published in The Journal of biological chemistry (07.11.2003)
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Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding
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Published in The Journal of biological chemistry (18.11.2005)
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Hydrogen tunneling in quinoproteins
Masgrau, Laura, Basran, Jaswir, Hothi, Parvinder, Sutcliffe, Michael J., Scrutton, Nigel S.
Published in Archives of Biochemistry and Biophysics (01.08.2004)
Published in Archives of Biochemistry and Biophysics (01.08.2004)
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Biodiversity of cytochrome P450 redox systems
McLean, K J, Sabri, M, Marshall, K R, Lawson, R J, Lewis, D G, Clift, D, Balding, P R, Dunford, A J, Warman, A J, McVey, J P, Quinn, A-M, Sutcliffe, M J, Scrutton, N S, Munro, A W
Published in Biochemical Society transactions (01.08.2005)
Published in Biochemical Society transactions (01.08.2005)
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Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase. Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes
Basran, J, Sutcliffe, M J, Scrutton, N S
Published in The Journal of biological chemistry (06.07.2001)
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Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6
Paine, Mark J.I., McLaughlin, Lesley A., Flanagan, Jack U., Kemp, Carol A., Sutcliffe, Michael J., Roberts, Gordon C.K., Wolf, C. Roland
Published in The Journal of biological chemistry (07.02.2003)
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Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition
Kemp, Carol A, Flanagan, Jack U, van Eldik, Annamaria J, Maréchal, Jean-Didier, Wolf, C. Roland, Roberts, Gordon C. K, Paine, Mark J. I, Sutcliffe, Michael J
Published in Journal of medicinal chemistry (21.10.2004)
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Design, synthesis and biological activity of new CDK4-specific inhibitors, based on fascaplysin
Aubry, C, Wilson, AJ, Jenkins, PR, Mahale, S, Chaudhuri, B, Marechal, JD, Sutcliffe, MJ
Published in Organic & biomolecular chemistry (01.01.2006)
Published in Organic & biomolecular chemistry (01.01.2006)
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Crystal structure of a PDZ domain
Cabral, João H. Morais, Petosa, Carlo, Sutcliffe, Michael J, Raza, Sami, Byron, Olwyn, Poy, Florence, Marfatia, Shirin M, Chishti, Athar H, Liddington, Robert C
Published in Nature (London) (15.08.1996)
Published in Nature (London) (15.08.1996)
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Thermodynamic and Biophysical Characterization of Cytochrome P450 BioI from Bacillus subtilis
Lawson, Rachel J, Leys, David, Sutcliffe, Michael J, Kemp, Carol A, Cheesman, Myles R, Smith, Susan J, Clarkson, John, Smith, W. Ewen, Haq, Ihtshamul, Perkins, John B, Munro, Andrew W
Published in Biochemistry (Easton) (05.10.2004)
Published in Biochemistry (Easton) (05.10.2004)
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