The absorption of darbepoetin alfa occurs predominantly via the lymphatics following subcutaneous administration to sheep
MCLENNAN, Danielle N, PORTER, Christopher J. H, EDWARDS, Glenn A, HEATHERINGTON, Anne C, MARTIN, Steven W, CHARMAN, Susan A
Published in Pharmaceutical research (01.09.2006)
Published in Pharmaceutical research (01.09.2006)
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The comparative antimalarial properties of weak base and neutral synthetic ozonides
Tang, Yuanqing, Wittlin, Sergio, Charman, Susan A., Chollet, Jacques, Chiu, Francis C.K., Morizzi, Julia, Johnson, Lisa M., Tomas, Josefina Santo, Scheurer, Christian, Snyder, Chistopher, Zhou, Lin, Dong, Yuxiang, Charman, William N., Matile, Hugues, Urwyler, Heinrich, Dorn, Arnulf, Vennerstrom, Jonathan L.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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The binding interaction of synthetic ozonide antimalarials with natural and modified β-cyclodextrins
Perry, Christine S., Charman, Susan A., Prankerd, Richard J., Chiu, Francis C.K., Scanlon, Martin J., Chalmers, David, Charman, William N.
Published in Journal of pharmaceutical sciences (01.01.2006)
Published in Journal of pharmaceutical sciences (01.01.2006)
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Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin
Charman, Susan A., Perry, Christine S., Chiu, Francis C.K., McIntosh, Kylie A., Prankerd, Richard J., Charman, William N.
Published in Journal of pharmaceutical sciences (01.02.2006)
Published in Journal of pharmaceutical sciences (01.02.2006)
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In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models
Schleiferböck, Sarah, Scheurer, Christian, Ihara, Masataka, Itoh, Isamu, Bathurst, Ian, Burrows, Jeremy N, Fantauzzi, Pascal, Lotharius, Julie, Charman, Susan A, Morizzi, Julia, Shackleford, David M, White, Karen L, Brun, Reto, Wittlin, Sergio
Published in Drug design, development and therapy (01.01.2013)
Published in Drug design, development and therapy (01.01.2013)
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Chemical Kinetics and Aqueous Degradation Pathways of a New Class of Synthetic Ozonide Antimalarials
Perry, Christine S., Charman, Susan A., Prankerd, Richard J., Chiu, Francis C.K., Dong, Yuxiang, Vennerstrom, Jonathan L., Charman, William N.
Published in Journal of pharmaceutical sciences (01.04.2006)
Published in Journal of pharmaceutical sciences (01.04.2006)
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Pharmacokinetic model to describe the lymphatic absorption of r-metHu-Leptin after subcutaneous injection to sheep
MCLENNAN, Danielle N, PORTER, Christopher J. H, EDWARDS, Glenn A, BRUMM, Maria, MARTIN, Steven W, CHARMAN, Susan A
Published in Pharmaceutical research (01.08.2003)
Published in Pharmaceutical research (01.08.2003)
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Pharmacokinetics and brain uptake of AM-36, a novel neuroprotective agent, following intravenous administration to rats
Nicolazzo, Joseph A, Nguyen, Tien T, Katneni, Kasiram, Steuten, Jessica A, Smith, Gregg, Jarrott, Bevyn, Callaway, Jennifer K, Charman, Susan A
Published in Journal of pharmacy and pharmacology (01.02.2008)
Published in Journal of pharmacy and pharmacology (01.02.2008)
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O3-05-04: The 8-hydroxyquinoline analog PBT2 rapidly restores cognition and reduces soluble Abeta in Alzheimer transgenic mice
Cherny, Robert A, Adlard, Paul A, Finkelstein, David I, Gautier, Elisabeth, Huggins, Penny, Parsons, Jack, Ritchie, Craig W, Robb, Elysia, Cortes, Mikhalina, Volitakis, Irene, Liu, Xiang, Smith, Jeffrey P, Perez, Keyla, Laughton, Katrina, Li, Qiao-Xin, Charman, Susan A, Nicolazzo, Joseph A, Wilkins, Simon, Deleva, Karolina, Kok, Gaik, Cappai, Roberto, Tanzi, Rudi E, Masters, Colin L, Barnham, Kevin J, Bush, Ashley I
Published in Alzheimer's & dementia (01.07.2008)
Published in Alzheimer's & dementia (01.07.2008)
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Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
Paquet, Tanya, Le Manach, Claire, Cabrera, Diego González, Younis, Yassir, Henrich, Philipp P, Abraham, Tara S, Lee, Marcus C S, Basak, Rajshekhar, Ghidelli-Disse, Sonja, Lafuente-Monasterio, María José, Bantscheff, Marcus, Ruecker, Andrea, Blagborough, Andrew M, Zakutansky, Sara E, Zeeman, Anne-Marie, White, Karen L, Shackleford, David M, Mannila, Janne, Morizzi, Julia, Scheurer, Christian, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Reader, Janette, Botha, Mariette, Dechering, Koen J, Sauerwein, Robert W, Tungtaeng, Anchalee, Vanachayangkul, Pattaraporn, Lim, Chek Shik, Burrows, Jeremy, Witty, Michael J, Marsh, Kennan C, Bodenreider, Christophe, Rochford, Rosemary, Solapure, Suresh M, Jiménez-Díaz, María Belén, Wittlin, Sergio, Charman, Susan A, Donini, Cristina, Campo, Brice, Birkholtz, Lyn-Marie, Hanson, Kirsten K, Drewes, Gerard, Kocken, Clemens H M, Delves, Michael J, Leroy, Didier, Fidock, David A, Waterson, David, Street, Leslie J, Chibale, Kelly
Published in Science translational medicine (26.04.2017)
Published in Science translational medicine (26.04.2017)
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A novel multiple-stage antimalarial agent that inhibits protein synthesis
Baragaña, Beatriz, Hallyburton, Irene, Lee, Marcus C. S., Norcross, Neil R., Grimaldi, Raffaella, Otto, Thomas D., Proto, William R., Blagborough, Andrew M., Meister, Stephan, Wirjanata, Grennady, Ruecker, Andrea, Upton, Leanna M., Abraham, Tara S., Almeida, Mariana J., Pradhan, Anupam, Porzelle, Achim, Martínez, María Santos, Bolscher, Judith M., Woodland, Andrew, Luksch, Torsten, Norval, Suzanne, Zuccotto, Fabio, Thomas, John, Simeons, Frederick, Stojanovski, Laste, Osuna-Cabello, Maria, Brock, Paddy M., Churcher, Tom S., Sala, Katarzyna A., Zakutansky, Sara E., Jiménez-Díaz, María Belén, Sanz, Laura Maria, Riley, Jennifer, Basak, Rajshekhar, Campbell, Michael, Avery, Vicky M., Sauerwein, Robert W., Dechering, Koen J., Noviyanti, Rintis, Campo, Brice, Frearson, Julie A., Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Gamo, Francisco Javier, Wyatt, Paul G., Leroy, Didier, Siegl, Peter, Delves, Michael J., Kyle, Dennis E., Wittlin, Sergio, Marfurt, Jutta, Price, Ric N., Sinden, Robert E., Winzeler, Elizabeth A., Charman, Susan A., Bebrevska, Lidiya, Gray, David W., Campbell, Simon, Fairlamb, Alan H., Willis, Paul A., Rayner, Julian C., Fidock, David A., Read, Kevin D., Gilbert, Ian H.
Published in Nature (London) (18.06.2015)
Published in Nature (London) (18.06.2015)
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Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
Adlard, Paul A., Cherny, Robert A., Finkelstein, David I., Gautier, Elisabeth, Robb, Elysia, Cortes, Mikhalina, Volitakis, Irene, Liu, Xiang, Smith, Jeffrey P., Perez, Keyla, Laughton, Katrina, Li, Qiao-Xin, Charman, Susan A., Nicolazzo, Joseph A., Wilkins, Simon, Deleva, Karolina, Lynch, Toni, Kok, Gaik, Ritchie, Craig W., Tanzi, Rudolph E., Cappai, Roberto, Masters, Colin L., Barnham, Kevin J., Bush, Ashley I.
Published in Neuron (Cambridge, Mass.) (10.07.2008)
Published in Neuron (Cambridge, Mass.) (10.07.2008)
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A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
Phillips, Margaret A, Lotharius, Julie, Marsh, Kennan, White, John, Dayan, Anthony, White, Karen L, Njoroge, Jacqueline W, El Mazouni, Farah, Lao, Yanbin, Kokkonda, Sreekanth, Tomchick, Diana R, Deng, Xiaoyi, Laird, Trevor, Bhatia, Sangeeta N, March, Sandra, Ng, Caroline L, Fidock, David A, Wittlin, Sergio, Lafuente-Monasterio, Maria, Benito, Francisco Javier Gamo, Alonso, Laura Maria Sanz, Martinez, Maria Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Haselden, John N, Louttit, James, Cui, Yi, Sridhar, Arun, Zeeman, Anna-Marie, Kocken, Clemens, Sauerwein, Robert, Dechering, Koen, Avery, Vicky M, Duffy, Sandra, Delves, Michael, Sinden, Robert, Ruecker, Andrea, Wickham, Kristina S, Rochford, Rosemary, Gahagen, Janet, Iyer, Lalitha, Riccio, Ed, Mirsalis, Jon, Bathhurst, Ian, Rueckle, Thomas, Ding, Xavier, Campo, Brice, Leroy, Didier, Rogers, M John, Rathod, Pradipsinh K, Burrows, Jeremy N, Charman, Susan A
Published in Science translational medicine (15.07.2015)
Published in Science translational medicine (15.07.2015)
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Lymphatic Transport of Halofantrine in the Conscious Rat When Administered as Either the Free Base or the Hydrochloride Salt: Effect of Lipid Class and Lipid Vehicle Dispersion
Porter, Christopher J.H., Charman, Susan A., Humberstone, Andrew J., Charman, William N.
Published in Journal of pharmaceutical sciences (01.04.1996)
Published in Journal of pharmaceutical sciences (01.04.1996)
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Increased In Vivo Exposure of N- to Achieve Plasma Concentrations Effective against Dengue Virus
Ma, Shackleford, David M, Charman, Susan A, Wagstaff, Kylie M, Porter, Christopher J. H, Jans, David A
Published in Pharmaceutics (01.07.2023)
Published in Pharmaceutics (01.07.2023)
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Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer
Sharma, Shikhar, Chung, Chi-Yeh, Uryu, Sean, Petrovic, Jelena, Cao, Joan, Rickard, Amanda, Nady, Nataliya, Greasley, Samantha, Johnson, Eric, Brodsky, Oleg, Khan, Showkhin, Wang, Hui, Wang, Zhenxiong, Zhang, Yong, Tsaparikos, Konstantinos, Chen, Lei, Mazurek, Anthony, Lapek, John, Kung, Pei-Pei, Sutton, Scott, Richardson, Paul F., Greenwald, Eric C., Yamazaki, Shinji, Jones, Rhys, Maegley, Karen A., Bingham, Patrick, Lam, Hieu, Stupple, Alexandra E., Kamal, Aileen, Chueh, Anderly, Cuzzupe, Anthony, Morrow, Benjamin J., Ren, Bin, Carrasco-Pozo, Catalina, Tan, Chin Wee, Bhuva, Dharmesh D., Allan, Elizabeth, Surgenor, Elliot, Vaillant, François, Pehlivanoglu, Havva, Falk, Hendrik, Whittle, James R., Newman, Janet, Cursons, Joseph, Doherty, Judy P., White, Karen L., MacPherson, Laura, Devlin, Mark, Dennis, Matthew L., Hattarki, Meghan K., De Silva, Melanie, Camerino, Michelle A., Butler, Miriam S., Dolezal, Olan, Pilling, Patricia, Foitzik, Richard, Stupple, Paul A., Lagiakos, H. Rachel, Walker, Scott R., Hediyeh-Zadeh, Soroor, Nuttall, Stewart, Spall, Sukhdeep K., Charman, Susan A., Connor, Theresa, Peat, Thomas S., Avery, Vicky M., Bozikis, Ylva E., Yang, Yuqing, Zhang, Ming, Monahan, Brendon J., Voss, Anne K., Thomas, Tim, Street, Ian P., Dawson, Sarah-Jane, Dawson, Mark A., Lindeman, Geoffrey J., Davis, Melissa J., Visvader, Jane E., Paul, Thomas A.
Published in Cell chemical biology (19.10.2023)
Published in Cell chemical biology (19.10.2023)
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UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria
Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzàlez, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly
Published in Antimicrobial agents and chemotherapy (01.09.2018)
Published in Antimicrobial agents and chemotherapy (01.09.2018)
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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
O’Neill, Paul M., Amewu, Richard K., Charman, Susan A., Sabbani, Sunil, Gnädig, Nina F., Straimer, Judith, Fidock, David A., Shore, Emma R., Roberts, Natalie L., Wong, Michael H.-L., Hong, W. David, Pidathala, Chandrakala, Riley, Chris, Murphy, Ben, Aljayyoussi, Ghaith, Gamo, Francisco Javier, Sanz, Laura, Rodrigues, Janneth, Cortes, Carolina Gonzalez, Herreros, Esperanza, Angulo-Barturén, Iñigo, Jiménez-Díaz, María Belén, Bazaga, Santiago Ferrer, Martínez-Martínez, María Santos, Campo, Brice, Sharma, Raman, Ryan, Eileen, Shackleford, David M., Campbell, Simon, Smith, Dennis A., Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N., Marfurt, Jutta, Palmer, Michael J., Copple, Ian M., Mercer, Amy E., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Siegl, Peter, Davies, Jill, Rochford, Rosemary, Kocken, Clemens H. M., Zeeman, Anne-Marie, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Published in Nature communications (24.05.2017)
Published in Nature communications (24.05.2017)
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