In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum
Maerki, Sonja, Brun, Reto, Charman, Susan A., Dorn, Arnulf, Matile, Hugues, Wittlin, Sergio
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Published in Journal of antimicrobial chemotherapy (01.07.2006)
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Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
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Published in ACS omega (31.08.2018)
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Lymphatic Transport of Proteins After Subcutaneous Administration
Porter, Christopher J.H., Charman, Susan A.
Published in Journal of pharmaceutical sciences (01.03.2000)
Published in Journal of pharmaceutical sciences (01.03.2000)
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Lauterwasser, Erica M. W, Fontaine, Shaun D, Li, Hao, Gut, Jiri, Katneni, Kasiram, Charman, Susan A, Rosenthal, Philip J, Bogyo, Matthew, Renslo, Adam R
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Published in ACS medicinal chemistry letters (12.11.2015)
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Probing a Potential In Vivo Drug–Excipient Interaction: Temporal Effects of a Modified β-Cyclodextrin on the Intravenous Pharmacokinetics of a Model High-Affinity Drug Ligand
Mannila, Anne, Morizzi, Julia, Nguyen, Thuy Tien, Charman, Susan A., Mcintosh, Michelle P., Shackleford, David M.
Published in Journal of pharmaceutical sciences (01.09.2012)
Published in Journal of pharmaceutical sciences (01.09.2012)
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Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides: Charting a Workable Structure−Activity Relationship Using Simple Prototypes
Dong, Yuxiang, Chollet, Jacques, Matile, Hugues, Charman, Susan A, Chiu, Francis C. K, Charman, William N, Scorneaux, Bernard, Urwyler, Heinrich, Santo Tomas, Josefina, Scheurer, Christian, Snyder, Christopher, Dorn, Arnulf, Wang, Xiaofang, Karle, Jean M, Tang, Yuanqing, Wittlin, Sergio, Brun, Reto, Vennerstrom, Jonathan L
Published in Journal of medicinal chemistry (28.07.2005)
Published in Journal of medicinal chemistry (28.07.2005)
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Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides
Tang, Yuanqing, Dong, Yuxiang, Wittlin, Sergio, Charman, Susan A., Chollet, Jacques, Chiu, Francis C.K., Charman, William N., Matile, Hugues, Urwyler, Heinrich, Dorn, Arnulf, Bajpai, Saroj, Wang, Xiaofang, Padmanilayam, Maniyan, Karle, Jean M., Brun, Reto, Vennerstrom, Jonathan L.
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Total Synthesis of Thiaplakortone A: Derivatives as Metabolically Stable Leads for the Treatment of Malaria
Pouwer, Rebecca H, Deydier, Sophie M, Le, Phuc Van, Schwartz, Brett D, Franken, Nicole C, Davis, Rohan A, Coster, Mark J, Charman, Susan A, Edstein, Michael D, Skinner-Adams, Tina S, Andrews, Katherine T, Jenkins, Ian D, Quinn, Ronald J
Published in ACS medicinal chemistry letters (13.02.2014)
Published in ACS medicinal chemistry letters (13.02.2014)
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Discovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for Malaria
Ge, Jian-Feng, Arai, Chika, Yang, Mei, Bakar Md, Abu, Lu, Jun, Ismail, Nasser S. M, Wittlin, Sergio, Kaiser, Marcel, Brun, Reto, Charman, Susan A, Nguyen, Tien, Morizzi, Julia, Itoh, Isamu, Ihara, Masataka
Published in ACS medicinal chemistry letters (14.10.2010)
Published in ACS medicinal chemistry letters (14.10.2010)
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Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine
Padmanilayam, Maniyan, Scorneaux, Bernard, Dong, Yuxiang, Chollet, Jacques, Matile, Hugues, Charman, Susan A., Creek, Darren J., Charman, William N., Tomas, Josefina Santo, Scheurer, Christian, Wittlin, Sergio, Brun, Reto, Vennerstrom, Jonathan L.
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity
Wang, Xiaofang, Creek, Darren J., Schiaffo, Charles E., Dong, Yuxiang, Chollet, Jacques, Scheurer, Christian, Wittlin, Sergio, Charman, Susan A., Dussault, Patrick H., Wood, James K., Vennerstrom, Jonathan L.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Modulation of Lymphocyte Potassium Channel K V 1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin
Ong, Seow Theng, Bajaj, Saumya, Tanner, Mark R, Chang, Shih Chieh, Krishnarjuna, Bankala, Ng, Xuan Rui, Morales, Rodrigo A V, Chen, Ming Wei, Luo, Dahai, Patel, Dharmeshkumar, Yasmin, Sabina, Ng, Jeremy Jun Heng, Zhuang, Zhong, Nguyen, Hai M, El Sahili, Abbas, Lescar, Julien, Patil, Rahul, Charman, Susan A, Robins, Edward G, Goggi, Julian L, Tan, Peng Wen, Sadasivam, Pragalath, Ramasamy, Boominathan, Hartimath, Siddana V, Dhawan, Vikas, Bednenko, Janna, Colussi, Paul, Wulff, Heike, Pennington, Michael W, Kuyucak, Serdar, Norton, Raymond S, Beeton, Christine, Chandy, K George
Published in ACS pharmacology & translational science (14.08.2020)
Published in ACS pharmacology & translational science (14.08.2020)
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Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes
Dong, Yuxiang, Tang, Yuanqing, Chollet, Jacques, Matile, Hugues, Wittlin, Sergio, Charman, Susan A., Charman, William N., Tomas, Josefina Santo, Scheurer, Christian, Snyder, Christopher, Scorneaux, Bernard, Bajpai, Saroj, Alexander, Scott A., Wang, Xiaofang, Padmanilayam, Maniyan, Cheruku, Srinivasa R., Brun, Reto, Vennerstrom, Jonathan L.
Published in Bioorganic & medicinal chemistry (15.09.2006)
Published in Bioorganic & medicinal chemistry (15.09.2006)
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Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277
Zhou, Lin, Alker, André, Ruf, Armin, Wang, Xiaofang, Chiu, Francis C.K., Morizzi, Julia, Charman, Susan A., Charman, William N., Scheurer, Christian, Wittlin, Sergio, Dong, Yuxiang, Hunziker, Daniel, Vennerstrom, Jonathan L.
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi
Keenan, Martine, Alexander, Paul W, Chaplin, Jason H, Abbott, Michael J, Diao, Hugo, Wang, Zhisen, Best, Wayne M, Perez, Catherine J, Cornwall, Scott M J, Keatley, Sarah K, Thompson, R C Andrew, Charman, Susan A, White, Karen L, Ryan, Eileen, Chen, Gong, Ioset, Jean-Robert, von Geldern, Thomas W, Chatelain, Eric
Published in Future medicinal chemistry (01.10.2013)
Published in Future medicinal chemistry (01.10.2013)
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Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy
Nicolazzo, Joseph A, Steuten, Jessica A, Charman, Susan A, Taylor, Nerida, Davies, Philip J, Petrou, Steven
Published in Clinical and experimental pharmacology & physiology (01.05.2010)
Published in Clinical and experimental pharmacology & physiology (01.05.2010)
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Discovery of CYT997: a structurally novel orally active microtubule targeting agent
Burns, Christopher J., Harte, Michael F., Bu, Xianyong, Fantino, Emmanuelle, Joffe, Max, Sikanyika, Harrison, Su, Stephen, Tranberg, C. Elisabet, Wilson, Neil, Charman, Susan A., Shackleford, David M., Wilks, Andrew F.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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2,4-Diaminothienopyrimidines as Orally Active Antimalarial Agents
González Cabrera, Diego, Le Manach, Claire, Douelle, Frederic, Younis, Yassir, Feng, Tzu-Shean, Paquet, Tanya, Nchinda, Aloysius T, Street, Leslie J, Taylor, Dale, de Kock, Carmen, Wiesner, Lubbe, Duffy, Sandra, White, Karen L, Zabiulla, K. Mohammed, Sambandan, Yuvaraj, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Charman, Susan A, Avery, Vicky M, Wittlin, Sergio, Chibale, Kelly
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Use of plasma proteins as solubilizing agents in in vitro permeability experiments: Correction for unbound drug concentration using the reciprocal permeability approach
Katneni, Kasiram, Charman, Susan A., Porter, Christopher J.H.
Published in Journal of pharmaceutical sciences (01.01.2008)
Published in Journal of pharmaceutical sciences (01.01.2008)
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Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-β-cyclodextrin or a co-solvent system
Koltun, Maria, Morizzi, Julia, Katneni, Kasiram, Charman, Susan A., Shackleford, David M., McIntosh, Michelle P.
Published in Biopharmaceutics & drug disposition (01.11.2010)
Published in Biopharmaceutics & drug disposition (01.11.2010)
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