Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia
Honore, Prisca, Chandran, Prasant, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen K., Ghilardi, Joseph R., Sevcik, Molly A., Fryer, Ryan M., Segreti, Jason A., Banfor, Patricia N., Marsh, Kennan, Neelands, Torben, Bayburt, Erol, Daanen, Jerome F., Gomtsyan, Arthur, Lee, Chih-Hung, Kort, Michael E., Reilly, Regina M., Surowy, Carol S., Kym, Philip R., Mantyh, Patrick W., Sullivan, James P., Jarvis, Michael F., Faltynek, Connie R.
Published in Pain (Amsterdam) (01.03.2009)
Published in Pain (Amsterdam) (01.03.2009)
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Fibromyalgia: mechanisms, current treatment and animal models
Brederson, Jill-Desiree, Jarvis, Michael F, Honore, Prisca, Surowy, Carol S
Published in Current pharmaceutical biotechnology (01.10.2011)
Published in Current pharmaceutical biotechnology (01.10.2011)
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SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore
Schrimpf, Michael R., Sippy, Kevin B., Briggs, Clark A., Anderson, David J., Li, Tao, Ji, Jianguo, Frost, Jennifer M., Surowy, Carol S., Bunnelle, William H., Gopalakrishnan, Murali, Meyer, Michael D.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel
Zhang, Xu-Feng, Han, Ping, Neelands, Torben R, McGaraughty, Steve, Honore, Prisca, Surowy, Carol S, Zhang, Di
Published in The Journal of general physiology (01.09.2011)
Published in The Journal of general physiology (01.09.2011)
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A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid
El Kouhen, Rachid, Surowy, Carol S, Bianchi, Bruce R, Neelands, Torben R, McDonald, Heath A, Niforatos, Wende, Gomtsyan, Arthur, Lee, Chih-Hung, Honore, Prisca, Sullivan, James P, Jarvis, Michael F, Faltynek, Connie R
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Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
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(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo
Surowy, Carol S, Neelands, Torben R, Bianchi, Bruce R, McGaraughty, Steve, El Kouhen, Rachid, Han, Ping, Chu, Katharine L, McDonald, Heath A, Vos, Melissa, Niforatos, Wende, Bayburt, Erol K, Gomtsyan, Arthur, Lee, Chih-Hung, Honore, Prisca, Sullivan, James P, Jarvis, Michael F, Faltynek, Connie R
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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Central Pituitary Adenylate Cyclase 1 Receptors Modulate Nociceptive Behaviors in Both Inflammatory and Neuropathic Pain States
Davis-Taber, Rachel, Baker, Scott, Lehto, Sonya G, Zhong, Chengmin, Surowy, Carol S, Faltynek, Connie R, Scott, Victoria E, Honore, Prisca
Published in The journal of pain (01.05.2008)
Published in The journal of pain (01.05.2008)
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Acidification of Rat TRPV1 Alters the Kinetics of Capsaicin Responses
Neelands, Torben R, Jarvis, Michael F, Han, Ping, Faltynek, Connie R, Surowy, Carol S
Published in Molecular pain (28.09.2005)
Published in Molecular pain (28.09.2005)
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[3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for the Human Transient Receptor Potential Vanilloid-1 (TRPV1) Receptor
Bianchi, Bruce R, El Kouhen, Rachid, Neelands, Torben R, Lee, Chih-Hung, Gomtsyan, Arthur, Raja, Shirish N, Vaidyanathan, Sriajan N, Surber, Bruce, McDonald, Heath A, Surowy, Carol S, Faltynek, Connie R, Moreland, Robert B, Jarvis, Michael F, Puttfarcken, Pamela S
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
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Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets
Zhang, Di, Saraf, Anita, Kolasa, Teodozyi, Bhatia, Pramila, Zheng, Guo Zhu, Patel, Meena, Lannoye, Greg S., Richardson, Paul, Stewart, Andrew, Rogers, John C., Brioni, Jorge D., Surowy, Carol S.
Published in Neuropharmacology (01.03.2007)
Published in Neuropharmacology (01.03.2007)
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Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management
Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Surowy, Carol S, Honore, Prisca, Marsh, Kennan C, Hannick, Steven M, McDonald, Heath A, Wetter, Jill M, Sullivan, James P, Jarvis, Michael F, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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SAR of alpha 7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore
Schrimpf, Michael R, Sippy, Kevin B, Briggs, Clark A, Anderson, David J, Li, Tao, Ji, Jianguo, Frost, Jennifer M, Surowy, Carol S, Bunnelle, William H, Gopalakrishnan, Murali, Meyer, Michael D
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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A Thallium Transport FLIPR-Based Assay for the Identification of KCC2-Positive Modulators
Zhang, Di, Gopalakrishnan, Sujatha M., Freiberg, Gail, Surowy, Carol S.
Published in Journal of biomolecular screening (01.02.2010)
Published in Journal of biomolecular screening (01.02.2010)
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Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties
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Published in Journal of medicinal chemistry (10.02.2005)
Published in Journal of medicinal chemistry (10.02.2005)
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Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists
Brown, Brian S., Keddy, Ryan, Zheng, Guo Zhu, Schmidt, Robert G., Koenig, John R., McDonald, Heath A., Bianchi, Bruce R., Honore, Prisca, Jarvis, Michael F., Surowy, Carol S., Polakowski, James S., Marsh, Kennan C., Faltynek, Connie R., Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
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Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists
Ji, Jianguo, Schrimpf, Michael R, Sippy, Kevin B, Bunnelle, William H, Li, Tao, Anderson, David J, Faltynek, Connie, Surowy, Carol S, Dyhring, Tino, Ahring, Philip K, Meyer, Michael D
Published in Journal of medicinal chemistry (01.11.2007)
Published in Journal of medicinal chemistry (01.11.2007)
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KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels
Zhang, Di, Thimmapaya, Rama, Zhang, Xu-Feng, Anderson, David J., Baranowski, John L., Scanio, Marc, Perez-Medrano, Arturo, Peddi, Sridhar, Wang, Zhi, Patel, Jyoti R., DeGoey, David A., Gopalakrishnan, Murali, Honore, Prisca, Yao, Betty B., Surowy, Carol S.
Published in Journal of neuroscience methods (30.08.2011)
Published in Journal of neuroscience methods (30.08.2011)
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Cracking the molecular weight barrier: Fragment screening of an aminotransferase using an NMR-based functional assay
Mendoza, Renaldo, Petros, Andrew M., Liu, Yaya, Thimmapaya, Rama, Surowy, Carol S., Leise, Walter F., Pereda-Lopez, Ana, Panchal, Sanjay C., Sun, Chaohong
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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