Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
Paquet, Tanya, Le Manach, Claire, Cabrera, Diego González, Younis, Yassir, Henrich, Philipp P, Abraham, Tara S, Lee, Marcus C S, Basak, Rajshekhar, Ghidelli-Disse, Sonja, Lafuente-Monasterio, María José, Bantscheff, Marcus, Ruecker, Andrea, Blagborough, Andrew M, Zakutansky, Sara E, Zeeman, Anne-Marie, White, Karen L, Shackleford, David M, Mannila, Janne, Morizzi, Julia, Scheurer, Christian, Angulo-Barturen, Iñigo, Martínez, María Santos, Ferrer, Santiago, Sanz, Laura María, Gamo, Francisco Javier, Reader, Janette, Botha, Mariette, Dechering, Koen J, Sauerwein, Robert W, Tungtaeng, Anchalee, Vanachayangkul, Pattaraporn, Lim, Chek Shik, Burrows, Jeremy, Witty, Michael J, Marsh, Kennan C, Bodenreider, Christophe, Rochford, Rosemary, Solapure, Suresh M, Jiménez-Díaz, María Belén, Wittlin, Sergio, Charman, Susan A, Donini, Cristina, Campo, Brice, Birkholtz, Lyn-Marie, Hanson, Kirsten K, Drewes, Gerard, Kocken, Clemens H M, Delves, Michael J, Leroy, Didier, Fidock, David A, Waterson, David, Street, Leslie J, Chibale, Kelly
Published in Science translational medicine (26.04.2017)
Published in Science translational medicine (26.04.2017)
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UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria
Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzàlez, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly
Published in Antimicrobial agents and chemotherapy (01.09.2018)
Published in Antimicrobial agents and chemotherapy (01.09.2018)
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In Vitro and In Vivo Efficacy of β-Lactams against Replicating and Slowly Growing/Nonreplicating Mycobacterium tuberculosis
SOLAPURE, Suresh, DINESH, Neela, PARAB, Manish, VISHWAS, K. G, KUMAR, Naveen, BALGANESH, Meenakshi, BALASUBRAMANIAN, V, SHANDIL, Radha, RAMACHANDRAN, Vasanthi, SHARMA, Sreevalli, BHATTACHARJEE, Deepa, GANGULY, Samit, REDDY, Jitendar, AHUJA, Vijaykamal, PANDUGA, Vijender
Published in Antimicrobial Agents and Chemotherapy (01.06.2013)
Published in Antimicrobial Agents and Chemotherapy (01.06.2013)
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Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria"
Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly
Published in Antimicrobial agents and chemotherapy (01.11.2018)
Published in Antimicrobial agents and chemotherapy (01.11.2018)
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Screening, identification, and characterization of mechanistically diverse inhibitors of the Mycobacterium tuberculosis enzyme, pantothenate kinase (CoaA)
Venkatraman, Janani, Bhat, Jyothi, Solapure, Suresh M, Sandesh, Jatheendranath, Sarkar, Debasmita, Aishwarya, Sundaram, Mukherjee, Kakoli, Datta, Santanu, Malolanarasimhan, Krishnan, Bandodkar, Balachandra, Das, Kaveri S
Published in Journal of biomolecular screening (01.03.2012)
Published in Journal of biomolecular screening (01.03.2012)
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A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coli
Barve, Aditya, Gupta, Anvita, Solapure, Suresh M, Kumar, Ansu, Ramachandran, Vasanthi, Seshadri, Kothandaraman, Vali, Shireen, Datta, Santanu
Published in Advances and applications in bioinformatics and chemistry (2010)
Published in Advances and applications in bioinformatics and chemistry (2010)
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Screen for Inhibitors of the Coupled Transglycosylase-Transpeptidase of Peptidoglycan Biosynthesis in Escherichia coli
RAMACHANDRAN, Vasanthi, CHANDRAKALA, B, KUMAR, Vidya P, USHA, Veeraraghavan, SOLAPURE, Suresh M, DE SOUSA, Sunita M
Published in Antimicrobial Agents and Chemotherapy (01.04.2006)
Published in Antimicrobial Agents and Chemotherapy (01.04.2006)
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High-throughput screening of RNA polymerase inhibitors using a fluorescent UTP analog
Bhat, Jyothi, Rane, Rajendra, Solapure, Suresh M, Sarkar, Dhiman, Sharma, Umender, Harish, M N, Lamb, Sarah, Plant, Darren, Alcock, Peter, Peters, Steve, Barde, Shubhada, Roy, Raman K
Published in Journal of biomolecular screening (01.12.2006)
Published in Journal of biomolecular screening (01.12.2006)
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1,4-azaindole, a potential drug candidate for treatment of tuberculosis
Chatterji, Monalisa, Shandil, Radha, Manjunatha, M R, Solapure, Suresh, Ramachandran, Vasanthi, Kumar, Naveen, Saralaya, Ramanatha, Panduga, Vijender, Reddy, Jitendar, Prabhakar, K R, Sharma, Sreevalli, Sadler, Claire, Cooper, Christopher B, Mdluli, Khisi, Iyer, Pravin S, Narayanan, Shridhar, Shirude, Pravin S
Published in Antimicrobial agents and chemotherapy (01.09.2014)
Published in Antimicrobial agents and chemotherapy (01.09.2014)
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Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo
Shirude, Pravin S, Shandil, Radha, Sadler, Claire, Naik, Maruti, Hosagrahara, Vinayak, Hameed, Shahul, Shinde, Vikas, Bathula, Chandramohan, Humnabadkar, Vaishali, Kumar, Naveen, Reddy, Jitendar, Panduga, Vijender, Sharma, Sreevalli, Ambady, Anisha, Hegde, Naina, Whiteaker, James, McLaughlin, Robert E, Gardner, Humphrey, Madhavapeddi, Prashanti, Ramachandran, Vasanthi, Kaur, Parvinder, Narayan, Ashwini, Guptha, Supreeth, Awasthy, Disha, Narayan, Chandan, Mahadevaswamy, Jyothi, Vishwas, KG, Ahuja, Vijaykamal, Srivastava, Abhishek, Prabhakar, KR, Bharath, Sowmya, Kale, Ramesh, Ramaiah, Manjunatha, Choudhury, Nilanjana Roy, Sambandamurthy, Vasan K, Solapure, Suresh, Iyer, Pravin S, Narayanan, Shridhar, Chatterji, Monalisa
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
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Evaluation of the metabolism, bioactivation and pharmacokinetics of triaminopyrimidine analogs toward selection of a potential candidate for antimalarial therapy
Srivastava, Abhishek, Panduga, Vijender, Saralaya, Ramanatha, K. R., Prabhakar, Hameed, Shahul, Solapure, Suresh, Hosagrahara, Vinayak P.
Published in Xenobiotica (02.11.2017)
Published in Xenobiotica (02.11.2017)
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Pharmacokinetic and Pharmacodynamic Evaluation of AZD5847 in a Mouse Model of Tuberculosis
BALASUBRAMANIAN, V, SOLAPURE, Suresh, MELNICK, David, BUTLER, Scott L, SHANDIL, Radha, GAONKAR, Sheshagiri, MAHESH, K. N, REDDY, Jitender, DESHPANDE, Abhijeet, BHARATH, Sowmya, KUMAR, Naveen, WRIGHT, Lindsay
Published in Antimicrobial agents and chemotherapy (01.07.2014)
Published in Antimicrobial agents and chemotherapy (01.07.2014)
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In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment
Singh, Ragini, Ramachandran, Vasanthi, Shandil, Radha, Sharma, Sreevalli, Khandelwal, Swati, Karmarkar, Malancha, Kumar, Naveen, Solapure, Suresh, Saralaya, Ramanatha, Nanduri, Robert, Panduga, Vijender, Reddy, Jitendar, Prabhakar, K R, Rajagopalan, Swaminathan, Rao, Narasimha, Narayanan, Shridhar, Anandkumar, Anand, Balasubramanian, V, Datta, Santanu
Published in Antimicrobial agents and chemotherapy (01.09.2015)
Published in Antimicrobial agents and chemotherapy (01.09.2015)
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Optimization of Pyrrolamides as Mycobacterial GyrB ATPase Inhibitors: Structure-Activity Relationship and In Vivo Efficacy in a Mouse Model of Tuberculosis
SHAHUL HAMEED, P, SOLAPURE, Suresh, GHOSH, Anirban, AWASTHY, Disha, SHANBHAG, Gajanan, SHEIKH, Gulebahar, MCMIKEN, Helen, PUTTUR, Jayashree, REDDY, Jitendar, WERNGREN, Jim, READ, Jon, KUMAR, Mahesh, MUKHERJEE, Kakoli, MANJUNATHA, R, CHINNAPATTU, Murugan, MADHAVAPEDDI, Prashanti, MANJREKAR, Praveena, BASU, Reetobrata, GAONKAR, Sheshagiri, SHARMA, Sreevalli, HOFFNER, Sven, HUMNABADKAR, Vaishali, SUBBULAKSHMI, Venkita, NANDI, Vrinda, PANDUGA, Vijender, WATERSON, David, SHANDIL, Radha, BALGANESH, Meenakshi, SAMBANDAMURTHY, Vasan K, ANAND KUMAR RAICHURKAR, DESHPANDE, Abhijeet
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
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Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway
Tantry, Subramanyam J., Shinde, Vikas, Balakrishnan, Gayathri, Markad, Shankar D., Gupta, Amit K., Bhat, Jyothi, Narayan, Ashwini, Raichurkar, Anandkumar, Jena, Lalit Kumar, Sharma, Sreevalli, Kumar, Naveen, Nanduri, Robert, Bharath, Sowmya, Reddy, Jitendar, Panduga, Vijender, Prabhakar, K. R., Kandaswamy, Karthikeyan, Kaur, Parvinder, Dinesh, Neela, Guptha, Supreeth, Saralaya, Ramanatha, Panda, Manoranjan, Rudrapatna, Suresh, Mallya, Meenakshi, Rubin, Harvey, Yano, Takahiro, Mdluili, Khisi, Cooper, Christopher B., Balasubramanian, V., Sambandamurthy, Vasan K., Ramachandran, Vasanthi, Shandil, Radha, Kavanagh, Stefan, Narayanan, Shridhar, Iyer, Pravin, Mukherjee, Kakoli, Hosagrahara, Vinayak P., Solapure, Suresh, Hameed, Shahul P., Ravishankar, Sudha
Published in MedChemComm (01.01.2016)
Published in MedChemComm (01.01.2016)
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Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding
Hameed P, Shahul, Manjrekar, Praveena, Raichurkar, Anandkumar, Shinde, Vikas, Puttur, Jayashree, Shanbhag, Gajanan, Chinnapattu, Murugan, Patil, Vikas, Rudrapatana, Suresh, Sharma, Sreevalli, Kumar, C. N. Naveen, Nandishaiah, Radha, Madhavapeddi, Prashanti, Sriram, D, Solapure, Suresh, Sambandamurthy, Vasan K
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
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Journal Article
Optimization of Pyrrolamides as Mycobacterial GyrB ATPase Inhibitors: Structure-Activity Relationship and In Vivo Efficacy in a Mouse Model of Tuberculosis
P, Shahul Hameed, Solapure, Suresh, Mukherjee, Kakoli, Nandi, Vrinda, Waterson, David, Shandil, Radha, Balganesh, Meenakshi, Sambandamurthy, Vasan K, Raichurkar, Anand Kumar, Deshpande, Abhijeet, Ghosh, Anirban, Awasthy, Disha, Shanbhag, Gajanan, Sheikh, Gulebahar, McMiken, Helen, Puttur, Jayashree, Reddy, Jitendar, Werngren, Jim, Read, Jon, Kumar, Mahesh, R, Manjunatha, Chinnapattu, Murugan, Madhavapeddi, Prashanti, Manjrekar, Praveena, Basu, Reetobrata, Gaonkar, Sheshagiri, Sharma, Sreevalli, Hoffner, Sven, Humnabadkar, Vaishali, Subbulakshmi, Venkita, Panduga, Vijender
Published in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (01.08.2014)
Published in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (01.08.2014)
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Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathwayThe authors declare no competing interests.Electronic supplementary information (ESI) available: Materials and methods, synthesis Schemes 1A and B, Fig. S1: 3D flexible superimposition of compounds 3h, 8d and 17a with bedaquiline, Fig. S2 and S3: 2D binding site interaction of inhibitors - bedaquiline, compounds 3h, 8d, 12 and 17a - at the ATPase binding site and
Tantry, Subramanyam J, Shinde, Vikas, Balakrishnan, Gayathri, Markad, Shankar D, Gupta, Amit K, Bhat, Jyothi, Narayan, Ashwini, Raichurkar, Anandkumar, Jena, Lalit Kumar, Sharma, Sreevalli, Kumar, Naveen, Nanduri, Robert, Bharath, Sowmya, Reddy, Jitendar, Panduga, Vijender, Prabhakar, K. R, Kandaswamy, Karthikeyan, Kaur, Parvinder, Dinesh, Neela, Guptha, Supreeth, Saralaya, Ramanatha, Panda, Manoranjan, Rudrapatna, Suresh, Mallya, Meenakshi, Rubin, Harvey, Yano, Takahiro, Mdluili, Khisi, Cooper, Christopher B, Balasubramanian, V, Sambandamurthy, Vasan K, Ramachandran, Vasanthi, Shandil, Radha, Kavanagh, Stefan, Narayanan, Shridhar, Iyer, Pravin, Mukherjee, Kakoli, Hosagrahara, Vinayak P, Solapure, Suresh, Hameed P, Shahul, Ravishankar, Sudha
Year of Publication 19.05.2016
Year of Publication 19.05.2016
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TRIAMINOPYRIMIDINE COMPOUNDS USEFUL FOR PREVENTING OR TREATING MALARIA
KOUSHIK, KRISHNA, VITHALRAO BELLALE, EKNATH, RAICHURKAR, ANANDKUMAR, LANDGE, SUDHIR, KIRTHIKA SAMBANDAMURTHY, VASAN, MURUGAN, KANNAN, SHANBHAG, GAJANAN, ROY CHOUDHURY, NILANJANA, SOLAPURE, SURESH, HAMEED PEER MOHAMED, SHAHUL, PATIL, VIKAS, NARAYANAN, SHRIDHAR, PUTTUR, JAYASHREE, IYER, PRAVIN
Year of Publication 23.08.2022
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Year of Publication 23.08.2022
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