Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes
Verma, Amit, Suragani, Rajasekhar Nvs, Aluri, Srinivas, Shah, Nishi, Bhagat, Tushar D, Alexander, Mark J, Komrokji, Rami, Kumar, Ravi
Published in The Journal of clinical investigation (01.02.2020)
Published in The Journal of clinical investigation (01.02.2020)
Get full text
Journal Article
ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders
Li, Jia, Fredericks, Maureen, Cannell, Marishka, Wang, Kathryn, Sako, Dianne, Maguire, Michelle C, Grenha, Rosa, Liharska, Katia, Krishnan, Lavanya, Bloom, Troy, Belcheva, Elitza P, Martinez, Pedro A, Castonguay, Roselyne, Keates, Sarah, Alexander, Mark J, Choi, Hyunwoo, Grinberg, Asya V, Pearsall, R Scott, Oh, Paul, Kumar, Ravindra, Suragani, Rajasekhar Nvs
Published in The Journal of clinical investigation (15.02.2021)
Published in The Journal of clinical investigation (15.02.2021)
Get full text
Journal Article
The function of heme-regulated eIF2α kinase in murine iron homeostasis and macrophage maturation
Liu, Sijin, Suragani, Rajasekhar N.V.S, Wang, Fudi, Han, Anping, Zhao, Wanting, Andrews, Nancy C, Chen, Jane-Jane
Published in The Journal of clinical investigation (01.11.2007)
Published in The Journal of clinical investigation (01.11.2007)
Get full text
Journal Article
Clonal Hematopoiesis-Related Mutations Are Associated with Favorable Clinical Benefit Following Luspatercept Treatment in Patients with Lower-Risk Myelodysplastic Syndromes: A Subgroup Analysis from the Phase 3 COMMANDS Trial
Hasan, Maroof, Vodala, Sadanand, Hayati, Sheida, Garcia-Manero, Guillermo, Gandhi, Anita K., Suragani, Rajasekhar N.V.S.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis
Suragani, Rajasekhar N V S, Cadena, Samuel M, Cawley, Sharon M, Sako, Dianne, Mitchell, Dianne, Li, Robert, Davies, Monique V, Alexander, Mark J, Devine, Matthew, Loveday, Kenneth S, Underwood, Kathryn W, Grinberg, Asya V, Quisel, John D, Chopra, Rajesh, Pearsall, R Scott, Seehra, Jasbir, Kumar, Ravindra
Published in Nature medicine (01.04.2014)
Published in Nature medicine (01.04.2014)
Get full text
Journal Article
Fedratinib Treatment Reduces the Inflammatory Cytokine Profile and Decreases Exhausted T Cells Correlating with Clinical Response in Patients with Myelofibrosis: Biomarker Analysis from the Phase 3 FREEDOM2 Trial
Jeyaraju, Danny, Hayati, Sheida, Wang, Jia, Harrison, Claire N, Kiladjian, Jean-Jacques, Hernandez, Christopher, Brown, Patrick, Lopes De Menezes, Daniel, Gandhi, Anita K., Suragani, Rajasekhar N.V.S.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
Luspatercept Modulates Inflammation in the Bone Marrow, Restores Effective Erythropoiesis/Hematopoiesis, and Provides Sustained Clinical Benefit Versus Epoetin Alfa (EA): Biomarker Analysis from the Phase 3 COMMANDS Study
Hayati, Sheida, Zeidan, Amer M., Garcia-Manero, Guillermo, Platzbecker, Uwe, Ahsan, Aarif, Verma, Amit K., Aluri, Srinivas, Guerrero, Manuel Ugidos, Gandhi, Anita K., Suragani, Rajasekhar N.V.S., Vodala, Sadanand
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
Predictive Biomarkers of Response to Luspatercept in Patients with Myelofibrosis- (MF) Associated Anemia: Biomarker Analysis from the ACE-536-MF-001 Study
Jeyaraju, Danny, Hayati, Sheida, Marsousi, Niloufar, Gerds, Aaron T., Passamonti, Francesco, Sanabria, Fabian, Vodala, Sadanand, Gandhi, Anita K., Suragani, Rajasekhar N.V.S.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
Investigations into the Mechanisms and Clinical Implications of Modulation of Hepcidin Levels By Luspatercept in TD MDS and TD b-Thalassemia
Ahsan, Aarif, Fang, Wei, Ugidos, Manuel, Jeyaraju, Danny V, Fenaux, Pierre, Platzbecker, Uwe, Hermine, Olivier, Porter, John B., Suragani, Rajasekhar N.V.S., Vodala, Sadanand, Gandhi, Anita K.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
The activin receptor ligand trap ActRIIB:ALK4‐Fc ameliorates cardiomyopathy induced by neuromuscular disease and diabetes
Li, Jia, Fredericks, Maureen, Tang, Mingxin, Cannell, Marishka, Joshi, Sachindra, Kumar, Ravindra, Andre, Patrick, Suragani, Rajasekhar N. V. S.
Published in FEBS letters (01.12.2022)
Published in FEBS letters (01.12.2022)
Get full text
Journal Article
Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia
Suragani, Rajasekhar N.V.S., Cawley, Sharon M., Li, Robert, Wallner, Samantha, Alexander, Mark J., Mulivor, Aaron W., Gardenghi, Sara, Rivella, Stefano, Grinberg, Asya V., Pearsall, R. Scott, Kumar, Ravindra
Published in Blood (19.06.2014)
Published in Blood (19.06.2014)
Get full text
Journal Article
Luspatercept Redistributes Body Iron to the Liver in Transfusion-Dependent-Thalassemia (TDT) during Erythropoietic Response
Garbowski, Maciej W., Ugidos, Manuel, Risueño, Alberto, Suragani, Rajasekhar N.V.S., Shetty, Jeevan K., Vodala, Sadanand, Thakurta, Anjan, Schwickart, Martin, Porter, John B.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
Get full text
Journal Article
Smad2/3‐pathway ligand trap luspatercept enhances erythroid differentiation in murine β‐thalassaemia by increasing GATA‐1 availability
Martinez, Pedro A., Li, Robert, Ramanathan, Harish N., Bhasin, Manoj, Pearsall, R. Scott, Kumar, Ravindra, Suragani, Rajasekhar N. V. S.
Published in Journal of cellular and molecular medicine (01.06.2020)
Published in Journal of cellular and molecular medicine (01.06.2020)
Get full text
Journal Article
Progress in Targeting the TGFβ Pathway
Verma, Amit, Suragani, Rajasekhar N.V.S., Alluri, Srinivas, Kumar, Ravi
Published in Clinical lymphoma, myeloma and leukemia (01.09.2019)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2019)
Get full text
Journal Article
An Integrated Single Cell Immunogenomic Atlas Reveals Pathways of Clonal Expansion, Inflammation and Dyserythropoiesis in Low and High-Risk Clonal Haematopoiesis
Zheng, Xuesen, Tan, Amandine, Casares Alaez, Maria del Pilar, Mallett, Garry, Kaya, Deniz Ece, Seymen, Nogayhan, Rzepkowska, Marta, Mackie, Sarah, Chatzikyriakou, Prodromos, Bogaanay, Laarni, Lewis, Jen, Hasan, Maroof, Suragani, Rajasekhar N.V.S., Carmichael, James, Mufti, Ghulam, Gandhi, Anita K., Napolitani, Giorgio, Quek, Lynn
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
Rap-536 Induces Reticulocyte Maturation in Wild-Type Mice, Increases Survival of Beta-Thalassemic Reticulocytes, and Increases Red Blood Cells in a Mouse Model of Alpha-Thalassemia
Acar, Melih, Jupelli, Madhulika, Abbiati, Roberto A., Ramanathan, Harish N., Santini, Cristina C., Ratushny, Alexander, Dunshee, Diana R., Lopes de Menezes, Daniel, MacBeth, Kyle, Suragani, Rajasekhar N.V.S., Loos, Remco, Schwickart, Martin
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
Get full text
Journal Article
Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily
Kumar, Ravindra, Grinberg, Asya V, Li, Huiming, Kuo, Tzu-Hsing, Sako, Dianne, Krishnan, Lavanya, Liharska, Katia, Li, Jia, Grenha, Rosa, Maguire, Michelle C, Briscoe, Steven D, Pearsall, R Scott, Herrin, Brantley R, Suragani, Rajasekhar N V S, Castonguay, Roselyne
Published in Scientific reports (15.09.2021)
Published in Scientific reports (15.09.2021)
Get full text
Journal Article