In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir
Tong, Xiao, Le Pogam, Sophie, Li, Lewyn, Haines, Kristin, Piso, Katherine, Baronas, Victoria, Yan, Jun-Mei, So, Sung-Sau, Klumpp, Klaus, Nájera, Isabel
Published in The Journal of infectious diseases (01.03.2014)
Published in The Journal of infectious diseases (01.03.2014)
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Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development
Zhang, Zhuming, Chu, Xin-Jie, Liu, Jin-Jun, Ding, Qingjie, Zhang, Jing, Bartkovitz, David, Jiang, Nan, Karnachi, Prabha, So, Sung-Sau, Tovar, Christian, Filipovic, Zoran M, Higgins, Brian, Glenn, Kelli, Packman, Kathryn, Vassilev, Lyubomir, Graves, Bradford
Published in ACS medicinal chemistry letters (13.02.2014)
Published in ACS medicinal chemistry letters (13.02.2014)
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Journal Article
Design of Libraries Targeting Protein-Protein Interfaces
Fry, David, Huang, Kuo-Sen, Di Lello, Paola, Mohr, Peter, Müller, Klaus, So, Sung-Sau, Harada, Takeo, Stahl, Martin, Vu, Binh, Mauser, Harald
Published in ChemMedChem (01.05.2013)
Published in ChemMedChem (01.05.2013)
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A Crowd-Based Process and Tool for HTS Hit Triage
Peng, Zhengwei, Gillespie, Paul, Weisel, Martin, So, Sung-Sau, So, W. Venus, Kondru, Rama, Narayanan, Arjun, Hermann, Johannes C.
Published in Molecular informatics (01.04.2013)
Published in Molecular informatics (01.04.2013)
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A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation
Lopez-Tapia, Francisco, Lou, Yan, Brotherton-Pleiss, Christine, Kuglstatter, Andreas, So, Sung-Sau, Kondru, Rama
Published in Bioorganic & medicinal chemistry letters (01.05.2019)
Published in Bioorganic & medicinal chemistry letters (01.05.2019)
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Discovery of 2‑[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia
Kelly, Martha J, Pietranico-Cole, Sherrie, Larigan, J. Douglas, Haynes, Nancy-Ellen, Reynolds, Charles H, Scott, Nathan, Vermeulen, John, Dvorozniak, Mark, Conde-Knape, Karin, Huang, Kuo-Sen, So, Sung-Sau, Thakkar, Kshitij, Qian, Yimin, Banner, Bruce, Mennona, Frank, Danzi, Sara, Klein, Irwin, Taub, Rebecca, Tilley, Jefferson
Published in Journal of medicinal chemistry (22.05.2014)
Published in Journal of medicinal chemistry (22.05.2014)
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Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods
Gathiaka, Symon, Palte, Rachel L., So, Sung-Sau, Chai, Xiaomei, Richard Miller, J., Kuvelkar, Reshma, Wen, Xiujuan, Cifelli, Steven, Kreamer, Anthony, Liaw, Andy, McLaren, David G., Fischer, Christian
Published in Bioorganic & medicinal chemistry letters (15.03.2023)
Published in Bioorganic & medicinal chemistry letters (15.03.2023)
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Journal Article
Enhancing Specificity and Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Chemical and Shape Features−A Case Study of HIV Protease Inhibitors
Pandit, Deepangi, So, Sung-Sau, Sun, Hongmao
Published in Journal of chemical information and modeling (01.05.2006)
Published in Journal of chemical information and modeling (01.05.2006)
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Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy
Byrne, Noel J., Lee, Amy C., Kostas, James, Reid, John C., Partridge, Andrea T., So, Sung-Sau, Cowan, Joseph E., Abeywickrema, Pravien, Huang, Hua, Zebisch, Matthias, Barker, John J., Soisson, Stephen M., Brooun, Alexei, Su, Hua-Poo
Published in Protein expression and purification (01.03.2021)
Published in Protein expression and purification (01.03.2021)
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Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors
Kühne, Holger, Obst-Sander, Ulrike, Kuhn, Bernd, Conte, Aurelia, Ceccarelli, Simona M., Neidhart, Werner, Rudolph, Markus G., Ottaviani, Giorgio, Gasser, Rodolfo, So, Sung-Sau, Li, Shirley, Zhang, Xiaolei, Gao, Lin, Myers, Michael
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
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Journal Article
Overview of artificial neural networks
Zou, Jinming, Han, Yi, So, Sung-Sau
Published in Methods in molecular biology (Clifton, N.J.) (2008)
Published in Methods in molecular biology (Clifton, N.J.) (2008)
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Journal Article
Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists
Gillespie, Paul, Goodnow, Robert A., Saha, Goutam, Bose, Gopal, Moulik, Kakali, Zwingelstein, Catherine, Myers, Michael, Conde-Knape, Karin, Pietranico-Cole, Sherrie, So, Sung-Sau
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
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Journal Article
Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs
Qian, Yimin, Conde-Knape, Karin, Erickson, Shawn D., Falcioni, Fiorenza, Gillespie, Paul, Hakimi, Irina, Mennona, Francis, Ren, Yonglin, Salari, Hamid, So, Sung-Sau, Tilley, Jefferson W.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
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Journal Article
Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity
Chu, Xin-Jie, DePinto, Wanda, Bartkovitz, David, So, Sung-Sau, Vu, Binh T, Packman, Kathryn, Lukacs, Christine, Ding, Qingjie, Jiang, Nan, Wang, Ka, Goelzer, Petra, Yin, Xuefeng, Smith, Melissa A, Higgins, Brian X, Chen, Yingsi, Xiang, Qing, Moliterni, John, Kaplan, Gerald, Graves, Bradford, Lovey, Allen, Fotouhi, Nader
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
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Journal Article
Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors
Qian, Yimin, Ahmad, Mushtaq, Chen, Shaoqing, Gillespie, Paul, Le, Nam, Mennona, Frank, Mischke, Steven, So, Sung-Sau, Wang, Hong, Burghardt, Charles, Tannu, Shahid, Conde-Knape, Karin, Kochan, Jarema, Bolin, David
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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