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Mechanism-based design of agents that selectively target drug-resistant glioma
Lin, Kingson, Gueble, Susan E., Sundaram, Ranjini K., Huseman, Eric D., Bindra, Ranjit S., Herzon, Seth B.
Published in Science (American Association for the Advancement of Science) (29.07.2022)
Published in Science (American Association for the Advancement of Science) (29.07.2022)
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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
Sulkowski, Parker L, Corso, Christopher D, Robinson, Nathaniel D, Scanlon, Susan E, Purshouse, Karin R, Bai, Hanwen, Liu, Yanfeng, Sundaram, Ranjini K, Hegan, Denise C, Fons, Nathan R, Breuer, Gregory A, Song, Yuanbin, Mishra-Gorur, Ketu, De Feyter, Henk M, de Graaf, Robin A, Surovtseva, Yulia V, Kachman, Maureen, Halene, Stephanie, Günel, Murat, Glazer, Peter M, Bindra, Ranjit S
Published in Science translational medicine (01.02.2017)
Published in Science translational medicine (01.02.2017)
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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair
Sulkowski, Parker L., Sundaram, Ranjini K., Oeck, Sebastian, Corso, Christopher D., Liu, Yanfeng, Noorbakhsh, Seth, Niger, Monica, Boeke, Marta, Ueno, Daiki, Kalathil, Aravind Nambiar, Bao, Xun, Li, Jing, Shuch, Brian, Bindra, Ranjit S., Glazer, Peter M.
Published in Nature genetics (01.08.2018)
Published in Nature genetics (01.08.2018)
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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Fons, Nathan R., Sundaram, Ranjini K., Breuer, Gregory A., Peng, Sen, McLean, Ryan L., Kalathil, Aravind N., Schmidt, Mark S., Carvalho, Diana M., Mackay, Alan, Jones, Chris, Carcaboso, Ángel M., Nazarian, Javad, Berens, Michael E., Brenner, Charles, Bindra, Ranjit S.
Published in Nature communications (22.08.2019)
Published in Nature communications (22.08.2019)
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TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor
Jo, Ukhyun, Murai, Yasuhisa, Agama, Keli K., Sun, Yilun, Saha, Liton Kumar, Yang, Xi, Arakawa, Yasuhiro, Gayle, Sophia, Jones, Kelli, Paralkar, Vishwas, Sundaram, Ranjini K., Van Doorn, Jinny, Vasquez, Juan C., Bindra, Ranjit S., Choi, Woo Suk, Pommier, Yves
Published in Molecular cancer therapeutics (05.07.2022)
Published in Molecular cancer therapeutics (05.07.2022)
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Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
Garbarino, Jennifer, Eckroate, Jillian, Sundaram, Ranjini K., Jensen, Ryan B., Bindra, Ranjit S.
Published in Translational oncology (01.09.2021)
Published in Translational oncology (01.09.2021)
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Temozolomide Sensitizes MGMT-Deficient Tumor Cells to ATR Inhibitors
Jackson, Christopher B., Noorbakhsh, Seth I., Sundaram, Ranjini K., Kalathil, Aravind N., Ganesa, Sachita, Jia, Lanqi, Breslin, Hank, Burgenske, Danielle M., Gilad, Oren, Sarkaria, Jann N., Bindra, Ranjit S.
Published in Cancer research (Chicago, Ill.) (01.09.2019)
Published in Cancer research (Chicago, Ill.) (01.09.2019)
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Prospective analysis of antigen-specific immunity, stem-cell antigens, and immune checkpoints in monoclonal gammopathy
Dhodapkar, Madhav V., Sexton, Rachael, Das, Rituparna, Dhodapkar, Kavita M., Zhang, Lin, Sundaram, Ranjini, Soni, Sonal, Crowley, John J., Orlowski, Robert Z., Barlogie, Bart
Published in Blood (26.11.2015)
Published in Blood (26.11.2015)
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PARG inhibition induces nuclear aggregation of PARylated PARP1
Paradkar, Sateja, Purcell, Julia, Cui, Annie, Friedman, Sam, Noronha, Katelyn J., Murray, Matthew A., Sundaram, Ranjini K., Bindra, Ranjit S., Jensen, Ryan B.
Published in Structure (London) (07.11.2024)
Published in Structure (London) (07.11.2024)
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Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors
Chen, Evan M., Quijano, Amanda R., Seo, Young-Eun, Jackson, Christopher, Josowitz, Alexander D., Noorbakhsh, Seth, Merlettini, Andrea, Sundaram, Ranjini K., Focarete, Maria Letizia, Jiang, Zhaozhong, Bindra, Ranjit S., Saltzman, W. Mark
Published in Biomaterials (01.09.2018)
Published in Biomaterials (01.09.2018)
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Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma
Richter, Joshua, Neparidze, Natalia, Zhang, Lin, Nair, Shiny, Monesmith, Tamara, Sundaram, Ranjini, Miesowicz, Fred, Dhodapkar, Kavita M., Dhodapkar, Madhav V.
Published in Blood (17.01.2013)
Published in Blood (17.01.2013)
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In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2
Gbyli, Rana, Song, Yuanbin, Liu, Wei, Gao, Yimeng, Biancon, Giulia, Chandhok, Namrata S., Wang, Xiaman, Fu, Xiaoying, Patel, Amisha, Sundaram, Ranjini, Tebaldi, Toma, Mamillapalli, Padmavathi, Zeidan, Amer M., Flavell, Richard A., Prebet, Thomas, Bindra, Ranjit S., Halene, Stephanie
Published in Leukemia (01.05.2022)
Published in Leukemia (01.05.2022)
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Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors
Murray, Matthew A., Noronha, Katelyn J., Wang, Yazhe, Friedman, Anna P., Paradkar, Sateja, Suh, Hee-Won, Sundaram, Ranjini K., Brenner, Charles, Saltzman, W.M., Bindra, Ranjit S.
Published in Molecular cancer therapeutics (01.08.2024)
Published in Molecular cancer therapeutics (01.08.2024)
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NAPRT Silencing in FH-Deficient Renal Cell Carcinoma Confers Therapeutic Vulnerabilities via NAD+ Depletion
Noronha, Katelyn J., Lucas, Karlie N., Paradkar, Sateja, Edmonds, Joseph, Friedman, Sam, Murray, Matthew A., Liu, Samantha, Sajed, Dipti P., Sachs, Chana, Spurrier, Josh, Raponi, Mitch, Liang, Jiayu, Zeng, Hao, Sundaram, Ranjini K., Shuch, Brian, Vasquez, Juan C., Bindra, Ranjit S.
Published in Molecular cancer research (02.10.2024)
Published in Molecular cancer research (02.10.2024)
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SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination
Daddacha, Waaqo, Koyen, Allyson E., Bastien, Amanda J., Head, PamelaSara E., Dhere, Vishal R., Nabeta, Geraldine N., Connolly, Erin C., Werner, Erica, Madden, Matthew Z., Daly, Michele B., Minten, Elizabeth V., Whelan, Donna R., Schlafstein, Ashley J., Zhang, Hui, Anand, Roopesh, Doronio, Christine, Withers, Allison E., Shepard, Caitlin, Sundaram, Ranjini K., Deng, Xingming, Dynan, William S., Wang, Ya, Bindra, Ranjit S., Cejka, Petr, Rothenberg, Eli, Doetsch, Paul W., Kim, Baek, Yu, David S.
Published in Cell reports (Cambridge) (22.08.2017)
Published in Cell reports (Cambridge) (22.08.2017)
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Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay
Surovtseva, Yulia V, Jairam, Vikram, Salem, Ahmed F, Sundaram, Ranjini K, Bindra, Ranjit S, Herzon, Seth B
Published in Journal of the American Chemical Society (23.03.2016)
Published in Journal of the American Chemical Society (23.03.2016)
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Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers
Huseman, Eric D., Lo, Anna, Fedorova, Olga, Elia, James L., Gueble, Susan E., Lin, Kingson, Sundaram, Ranjini K., Oh, Joonseok, Liu, Jinchan, Menges, Fabian, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Batista, Victor S., Crawford, Jason M., Pyle, Anna M., Bindra, Ranjit S., Herzon, Seth B.
Published in Journal of the American Chemical Society (10.07.2024)
Published in Journal of the American Chemical Society (10.07.2024)
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Local DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas
King, Amanda R., Corso, Christopher D., Chen, Evan M., Song, Eric, Bongiorni, Paul, Chen, Zhe, Sundaram, Ranjini K., Bindra, Ranjit S., Saltzman, W. Mark
Published in Molecular cancer therapeutics (01.08.2017)
Published in Molecular cancer therapeutics (01.08.2017)
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Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore
Paradkar, Sateja, Herrington, James, Hendricson, Adam, Hewawasam, Piyasena, Plummer, Mark, Hoyer, Denton, Sundaram, Ranjini K., Surovtseva, Yulia V., Bindra, Ranjit S.
Published in Oncotarget (27.04.2021)
Published in Oncotarget (27.04.2021)
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