Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein
Lin, Te-Hsien, Chang, Kuo-Hsuan, Chiu, Ya-Jen, Weng, Zheng-Kui, Sun, Ying-Chieh, Lin, Wenwei, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Published in International journal of molecular sciences (22.10.2022)
Published in International journal of molecular sciences (22.10.2022)
Get full text
Journal Article
A Novel Sialyltransferase Inhibitor Suppresses FAK/Paxillin Signaling and Cancer Angiogenesis and Metastasis Pathways
CHEN, Jia-Yang, TANG, Yen-An, LI, Wen-Shan, CHENG, Hung-Chi, WANG, Yi-Ching, HUANG, Sin-Ming, JUAN, Hsueh-Fen, WU, Li-Wha, SUN, Ying-Chieh, WANG, Szu-Chi, WU, Kuan-Wei, BALRAJ, Gopula, CHANG, Tzu-Ting
Published in Cancer research (Chicago, Ill.) (15.01.2011)
Published in Cancer research (Chicago, Ill.) (15.01.2011)
Get full text
Journal Article
Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 TauRD-DsRed SH-SY5Y Cells
Chiang, Ni-Ni, Lin, Te-Hsien, Teng, Yu-Shan, Sun, Ying-Chieh, Chang, Kuo-Hsuan, Lin, Chung-Yin, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Chen, Chiung-Mei, Lee-Chen, Guey-Jen
Published in Frontiers in aging neuroscience (15.12.2021)
Published in Frontiers in aging neuroscience (15.12.2021)
Get full text
Journal Article
Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against Aβ Toxicity
Huang, Ching-Chia, Chang, Kuo-Hsuan, Chiu, Ya-Jen, Chen, Yi-Ru, Lung, Tsai-Hui, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Sun, Ying-Chieh, Chen, Chiung-Mei, Lin, Wenwei, Lee-Chen, Guey-Jen
Published in Cells (Basel, Switzerland) (09.11.2021)
Published in Cells (Basel, Switzerland) (09.11.2021)
Get full text
Journal Article
Using ΔK280 TauRD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy
Weng, Zheng-Kui, Lin, Te-Hsien, Chang, Kuo-Hsuan, Chiu, Ya-Jen, Lin, Chih-Hsin, Tseng, Pei-Hsuan, Sun, Ying-Chieh, Lin, Wenwei, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Published in Biomolecules (Basel, Switzerland) (23.01.2023)
Published in Biomolecules (Basel, Switzerland) (23.01.2023)
Get full text
Journal Article
A reversible surface functionalized nanowire transistor to study protein–protein interactions
Lin, Shu-Ping, Pan, Chien-Yuan, Tseng, Kun-Chang, Lin, Ming-Chou, Chen, Chii-Dong, Tsai, Chia-Chang, Yu, Shu-Han, Sun, Ying-Chieh, Lin, Tsung-Wu, Chen, Yit-Tsong
Published in Nano today (01.06.2009)
Published in Nano today (01.06.2009)
Get full text
Journal Article
Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay
Hsu, Chia‐Jen, Hsu, Wen‐Chi, Lee, Der‐Jay, Liu, An‐Lun, Chang, Chia‐Ming, Shih, Huei‐Jhen, Huang, Wun‐Han, Lee‐Chen, Guey‐Jen, Hsieh‐Li, Hsiu Mei, Lee, Guan‐Chiun, Sun, Ying‐Chieh
Published in Chemical biology & drug design (01.08.2017)
Published in Chemical biology & drug design (01.08.2017)
Get full text
Journal Article
Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cancer
TAN, Yi-Hung, LEE, Kung-Hsueh, LIN, Topp, SUN, Ying-Chieh, HSIU MEI HSIEH-LI, JUAN, Hsueh-Fen, WANG, Yi-Ching
Published in Clinical cancer research (15.03.2008)
Published in Clinical cancer research (15.03.2008)
Get full text
Journal Article
LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease
Fan, Chia-Hao, Lin, Chia-Wei, Huang, Hei-Jen, Lee-Chen, Guey-Jen, Sun, Ying-Chieh, Lin, Wenwei, Chen, Chiung-Mei, Chang, Kuo-Hsuan, Su, Ming-Tsan, Hsieh-Li, Hsiu Mei
Published in Psychopharmacology (01.10.2020)
Published in Psychopharmacology (01.10.2020)
Get full text
Journal Article
Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice
Huang, Hei-Jen, Chen, Shu-Ling, Huang, Hsin-Yu, Sun, Ying-Chieh, Lee, Guan-Chiun, Lee-Chen, Guey-Jen, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan
Published in Psychopharmacology (01.02.2019)
Published in Psychopharmacology (01.02.2019)
Get full text
Journal Article
Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease
Chiu, Ya-Jen, Hsieh, Yu-Hsuan, Lin, Te-Hsien, Lee, Guan-Chiun, Hsieh-Li, Hsiu Mei, Sun, Ying-Chieh, Chen, Chiung-Mei, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Published in Neurochemistry international (01.05.2019)
Published in Neurochemistry international (01.05.2019)
Get full text
Journal Article
Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases
Chung, Yu-Han, Lin, Chia-Wei, Huang, Hsin-Yu, Chen, Shu-Ling, Huang, Hei-Jen, Sun, Ying-Chieh, Lee, Guan-Chiun, Lee-Chen, Guey-Jen, Chang, Ya-Ching, Hsieh-Li, Hsiu Mei
Published in Journal of molecular neuroscience (01.07.2020)
Published in Journal of molecular neuroscience (01.07.2020)
Get full text
Journal Article
A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment
Chiu, Ya-Jen, Teng, Yu-Shan, Chen, Chiung-Mei, Sun, Ying-Chieh, Hsieh-Li, Hsiu Mei, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Published in Biomolecules & therapeutics (01.05.2023)
Published in Biomolecules & therapeutics (01.05.2023)
Get full text
Journal Article
Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines
Li, Huang-Yi, Lee, Jay-Der, Chen, Chiao-Wen, Sun, Ying-Chieh, Cheng, Wei-Chieh
Published in European journal of medicinal chemistry (20.01.2018)
Published in European journal of medicinal chemistry (20.01.2018)
Get full text
Journal Article
Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2 H -Chromen-2-One Activates CREB-Mediated Neuroprotection in A β and Tau Cell Models of Alzheimer's Disease
Chiu, Ya-Jen, Lin, Te-Hsien, Chen, Chiung-Mei, Lin, Chih-Hsin, Teng, Yu-Shan, Lin, Chung-Yin, Sun, Ying-Chieh, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Lee-Chen, Guey-Jen, Lin, Wenwei, Chang, Kuo-Hsuan
Published in Oxidative medicine and cellular longevity (2021)
Published in Oxidative medicine and cellular longevity (2021)
Get full text
Journal Article
Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays
Lin, Chih-Hsin, Hsieh, Yu-Shao, Wu, Yih-Ru, Hsu, Chia-Jen, Chen, Hsuan-Chiang, Huang, Wun-Han, Chang, Kuo-Hsuan, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Sun, Ying-Chieh, Lee, Guan-Chiun, Lee-Chen, Guey-Jen
Published in European journal of pharmaceutical sciences (30.06.2016)
Published in European journal of pharmaceutical sciences (30.06.2016)
Get full text
Journal Article
Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity
Lin, Chih-Hsin, Hsieh, Yu-Shao, Sun, Ying-Chieh, Huang, Wun-Han, Chen, Shu-Ling, Weng, Zheng-Kui, Lin, Te-Hsien, Wu, Yih-Ru, Chang, Kuo-Hsuan, Huang, Hei-Jen, Lee, Guan-Chiun, Hsieh-Li, Hsiu Mei, Lee-Chen, Guey-Jen
Published in Biomolecules & therapeutics (01.01.2023)
Published in Biomolecules & therapeutics (01.01.2023)
Get full text
Journal Article
Computation of relative binding free energy for an inhibitor and its analogs binding with Erk kinase using thermodynamic integration MD simulation
Wu, Kuan-Wei, Chen, Po-Chin, Wang, Jun, Sun, Ying-Chieh
Published in Journal of computer-aided molecular design (01.10.2012)
Published in Journal of computer-aided molecular design (01.10.2012)
Get full text
Journal Article