Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers
Qiu, Luping, Levine, Kymberly, Gajiwala, Ketan S, Cronin, Ciarán N, Nagata, Asako, Johnson, Eric, Kraus, Michelle, Tatlock, John, Kania, Robert, Foley, Timothy, Sun, Shaoxian
Published in PloS one (07.06.2018)
Published in PloS one (07.06.2018)
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Liverome: a curated database of liver cancer-related gene signatures with self-contained context information
Lee, Langho, Wang, Kai, Li, Gang, Xie, Zhi, Wang, Yuli, Xu, Jiangchun, Sun, Shaoxian, Pocalyko, David, Bhak, Jong, Kim, Chulhong, Lee, Kee-Ho, Jang, Ye Jin, Yeom, Young Il, Yoo, Hyang-Sook, Hwang, Seungwoo
Published in BMC genomics (30.11.2011)
Published in BMC genomics (30.11.2011)
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Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR
Le, Phuong T., Cheng, Hengmiao, Ninkovic, Sacha, Plewe, Michael, Huang, Xiaojun, Wang, Hai, Bagrodia, Shubha, Sun, Shaoxian, Knighton, Daniel R., LaFleur Rogers, Caroline M., Pannifer, Andrew, Greasley, Samantha, Dalvie, Deepak, Zhang, Eric
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
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Journal Article
Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors
Liu, Kevin K.C., Huang, Xiaojun, Bagrodia, Shubha, Chen, Jeffrey H., Greasley, Samantha, Cheng, Hengmiao, Sun, Shaoxian, Knighton, Dan, Rodgers, Caroline, Rafidi, Kristina, Zou, Aihua, Xiao, Jiezhan, Yan, Shengyong
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
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Journal Article
4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors
Liu, Kevin K.-C., Bagrodia, Shubha, Bailey, Simon, Cheng, Hengmiao, Chen, Hui, Gao, Lisa, Greasley, Samantha, Hoffman, Jacqui E., Hu, Qiyue, Johnson, Ted O., Knighton, Dan, Liu, Zhengyu, Marx, Matthew A., Nambu, Mitchell D., Ninkovic, Sacha, Pascual, Bernadette, Rafidi, Kristina, Rodgers, Caroline M.-L., Smith, Graham L., Sun, Shaoxian, Wang, Haitao, Yang, Anle, Yuan, Jing, Zou, Aihua
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Pyridine-2-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
Humphries, Paul S., Almaden, Jonathon V., Barnum, Sandra J., Carlson, Thomas J., Do, Quyen-Quyen T., Fraser, James D., Hess, Mary, Kim, Young H., Ogilvie, Kathleen M., Sun, Shaoxian
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
Humphries, Paul S., Bailey, Simon, Almaden, Jonathon V., Barnum, Sandra J., Carlson, Thomas J., Christie, Lance C., Do, Quyen-Quyen T., Fraser, James D., Hess, Mary, Kellum, Jack, Kim, Young H., McClellan, Guy A., Ogilvie, Kathleen M., Simmons, Brett H., Skalitzky, Donald, Sun, Shaoxian, Wilhite, David, Zehnder, Luke R.
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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Journal Article
Ligand and coactivator recruitment preferences of peroxisome proliferator activated receptor α
Mukherjee, Ranjan, Sun, Shaoxian, Santomenna, Linda, Miao, Bowman, Walton, Harry, Liao, Boshan, Locke, Kenneth, Zhang, Ji-Hu, Nguyen, Sonny H., Zhang, Li Tao, Murphy, Kathleen, Ross, Harold O, Xia, M.X., Teleha, Christopher, Chen, S.-Y., Selling, Bernard, Wynn, Richard, Burn, Timothy, Young, Peter R.
Published in The Journal of steroid biochemistry and molecular biology (01.07.2002)
Published in The Journal of steroid biochemistry and molecular biology (01.07.2002)
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PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity
Yuan, Jing, Mehta, Pramod P, Yin, Min-Jean, Sun, Shaoxian, Zou, Aihua, Chen, Jeffrey, Rafidi, Kristina, Feng, Zheng, Nickel, Jeffrey, Engebretsen, Jon, Hallin, Jill, Blasina, Alessandra, Zhang, Eric, Nguyen, Leslie, Sun, Minghao, Vogt, Peter K, McHarg, Aileen, Cheng, Hengmiao, Christensen, James G, Kan, Julie L C, Bagrodia, Shubha
Published in Molecular cancer therapeutics (01.11.2011)
Published in Molecular cancer therapeutics (01.11.2011)
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Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series
Cheng, Hengmiao, Hoffman, Jacqui E., Le, Phuong T., Pairish, Mason, Kania, Robert, Farrell, William, Bagrodia, Shubha, Yuan, Jing, Sun, Shaoxian, Zhang, Eric, Xiang, Cathy, Dalvie, Deepak, Rahavendran, Sadayappan V.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Journal Article
Glucose Modulation of Glucokinase Activation by Small Molecules
Ralph, Erik C, Thomson, Jim, Almaden, Jonathan, Sun, Shaoxian
Published in Biochemistry (Easton) (29.04.2008)
Published in Biochemistry (Easton) (29.04.2008)
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Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier
Rohner, Allison, Spilker, Mary E, Lam, Justine L, Pascual, Bernadette, Bartkowski, Darian, Li, Qing John, Yang, Amy H, Stevens, Greg, Xu, Meirong, Wells, Peter A, Planken, Simon, Nair, Sajiv, Sun, Shaoxian
Published in Molecular cancer therapeutics (01.01.2012)
Published in Molecular cancer therapeutics (01.01.2012)
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Journal Article
Abstract 2570: Discovery of potent, selective, and orally available WEE1 inhibitors that demonstrate increased DNA damage and mitosis in tumor cells leading to tumor regression in vivo
Sun, Shaoxian, Silvergleid, Sarah, Gerasyuto, Aleksey I., Wang, Jiashi, Pelletier, Robert D., Placzek, Andrew, Knight, Jennifer L., Clark, Anthony, Wright, Hamish, Yin, Wu, Elk, Jackson Chief, Bell, Jeff, Bos, Pieter H., Boyles, Nicholas A., Therrien, Eric, Jensen, Kristian, Akinsanya, Karen
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Preclinical PK/PD modeling and human efficacious dose projection for a glucokinase activator in the treatment of diabetes
Zager, Michael G., Kozminski, Kirk, Pascual, Bernadette, Ogilvie, Kathleen M., Sun, Shaoxian
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2014)
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2014)
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Journal Article
Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design
Cheng, Hengmiao, Bagrodia, Shubha, Bailey, Simon, Edwards, Martin, Hoffman, Jacqui, Hu, Qiyue, Kania, Robert, Knighton, Daniel R., Marx, Matthew A., Ninkovic, Sacha, Sun, Shaoxian, Zhang, Eric
Published in MedChemComm (01.08.2010)
Published in MedChemComm (01.08.2010)
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