Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
Gentles, Robert G., Ding, Min, Bender, John A., Bergstrom, Carl P., Grant-Young, Katharine, Hewawasam, Piyasena, Hudyma, Thomas, Martin, Scott, Nickel, Andrew, Regueiro-Ren, Alicia, Tu, Yong, Yang, Zhong, Yeung, Kap-Sun, Zheng, Xiaofan, Chao, Sam, Sun, Jung-Hui, Beno, Brett R., Camac, Daniel M., Chang, Chong-Hwan, Gao, Mian, Morin, Paul E., Sheriff, Steven, Tredup, Jeff, Wan, John, Witmer, Mark R., Xie, Dianlin, Hanumegowda, Umesh, Knipe, Jay, Mosure, Kathy, Santone, Kenneth S., Parker, Dawn D., Zhuo, Xiaoliang, Lemm, Julie, Liu, Mengping, Pelosi, Lenore, Rigat, Karen, Voss, Stacey, Wang, Yi, Wang, Ying-Kai, Colonno, Richard J., Gao, Min, Roberts, Susan B., Gao, Qi, Ng, Alicia, Meanwell, Nicholas A, Kadow, John F.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor
Quan, Mimi L, Lam, Patrick Y. S, Han, Qi, Pinto, Donald J. P, He, Ming Y, Li, Renhua, Ellis, Christopher D, Clark, Charles G, Teleha, Christopher A, Sun, Jung-Hui, Alexander, Richard S, Bai, Steve, Luettgen, Joseph M, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Evolution of the Synthetic Process to an Advanced GPR40 Agonist
Hou, Xiaoping, Hernandez, Lucas W., Jurica, Elizabeth A., Zhao, Rulin, Wang, Bei, Wong, Michael, Sun, Jung-Hui, Sun, Dawn, Wu, Dauh-Rurng, Yuan, Changxia, Hay, Michael, Yu, Miao, Wu, Ximao, Huang, Yanting, Ellsworth, Bruce A., Bobes, Francisco Gonzalez, Mathur, Arvind, Kempson, James
Published in Organic process research & development (19.01.2024)
Published in Organic process research & development (19.01.2024)
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Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders
Meng, Wei, Brigance, Robert, Mignone, James, Negash, Lidet, Zhao, Guohua, Ahmad, Saleem, Wang, Wei, Moore, Fang, Ye, Xiang-Yang, Sun, Jung-Hui, Mathur, Arvind, Li, Yi-Xin, Azzara, Anthony, Ma, Zhengping, Chu, Ching-Hsuen, Cullen, Mary Jane, Rooney, Suzanne, Harvey, Susan, Kopcho, Lisa, Abell, Lynn, O’Malley, Kevin, Keim, William, Dierks, Elizabeth A., Chang, Shu, Foster, Kimberly A., Harden, David, Dabros, Marta, Goti, Vineet, De Oliveira, Claudia, Krishna, Gopal, Pelleymounter, Mary Ann, Whaley, Jean, Robl, Jeffrey A., Cheng, Dong, Devasthale, Pratik
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Efficient Synthesis of 5-(Bromomethyl)- and 5-(Aminomethyl)-1-THP-Indazole
Sun, Jung-Hui, Teleha, Christopher A, Yan, Jia-Sheng, Rodgers, James D, Nugiel, David A
Published in Journal of organic chemistry (08.08.1997)
Published in Journal of organic chemistry (08.08.1997)
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Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups
Corte, James R, Pinto, Donald J. P, Fang, Tianan, Osuna, Honey, Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Sun, Jung-Hui, Rampulla, Richard, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Li, Yi-Xin Cindy, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Harper, Timothy W, Huang, Christine, Zheng, Joanna J, Bozarth, Jeffrey M, Wu, Yiming, Wong, Pancras C, Crain, Earl J, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272
Kempson, James, Hou, Xiaoping, Sun, Jung-Hui, Wong, Michael, Pawluczyk, Joseph, Li, Jianqing, Krishnananthan, Subramaniam, Simmons, Eric M, Hsiao, Yi, Li, Yi-Xin, Sun, Dawn, Wu, Dauh-Rurng, Meng, Wei, Ahmad, Saleem, Negash, Lidet, Brigance, Robert, Turdi, Huji, Hangeland, Jon J, Lawrence, R. Michael, Devasthale, Pratik, Robl, Jeffrey A, Mathur, Arvind
Published in Organic process research & development (15.04.2022)
Published in Organic process research & development (15.04.2022)
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Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097
Mathur, Arvind, Wang, Bei, Smith, Daniel, Li, Jianqing, Pawluczyk, Joseph, Sun, Jung-Hui, Wong, Michael Kwok, Krishnananthan, Subramaniam, Wu, Dauh-Rurng, Sun, Dawn, Li, Peng, Yip, Shiuhang, Chen, Bang-Chi, Baran, Phil S, Chen, Qi, Lopez, Omar D, Yong, Zhong, Bender, John A, Nguyen, Van N, Romine, Jeffrey L, Laurent, Denis R. St, Wang, Gan, Kadow, John F, Meanwell, Nicholas A, Belema, Makonen, Zhao, Rulin
Published in Journal of organic chemistry (06.10.2017)
Published in Journal of organic chemistry (06.10.2017)
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Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors
Wityak, John, Hobbs, Frank W., Gardner, Daniel S., Santella, Joseph B., Petraitis, Joseph J., Sun, Jung-Hui, Favata, Margaret F., Daulerio, Andrea J., Horiuchi, Kurumi Y., Copeland, Robert A., Scherle, Peggy A., Jaffe, Bruce D., Trzaskos, James M., Magolda, Ronald L., Trainor, George L., Duncia, John V.
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor
Liu, Chunjian, Lin, James, Hynes, John, Wu, Hong, Wrobleski, Stephen T, Lin, Shuqun, Dhar, T G Murali, Vrudhula, Vivekananda M, Sun, Jung-Hui, Chao, Sam, Zhao, Rulin, Wang, Bei, Chen, Bang-Chi, Everlof, Gerry, Gesenberg, Christoph, Zhang, Hongjian, Marathe, Punit H, McIntyre, Kim W, Taylor, Tracy L, Gillooly, Kathleen, Shuster, David J, McKinnon, Murray, Dodd, John H, Barrish, Joel C, Schieven, Gary L, Leftheris, Katerina
Published in Journal of medicinal chemistry (08.10.2015)
Published in Journal of medicinal chemistry (08.10.2015)
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Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms
Wan, Honghe, Schroeder, Gretchen M, Hart, Amy C, Inghrim, Jennifer, Grebinski, James, Tokarski, John S, Lorenzi, Matthew V, You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J, Trainor, George L, Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S, Khan, Javed A, Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K, Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N, Pragalathan, Bala, Narayanan, Sankara, K.C, Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
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Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression
Degnan, Andrew P, Tora, George O, Huang, Hong, Conlon, David A, Davis, Carl D, Hanumegowda, Umesh M, Hou, Xiaoping, Hsiao, Yi, Hu, Joanna, Krause, Rudolph, Li, Yu-Wen, Newton, Amy E, Pieschl, Rick L, Raybon, Joseph, Rosner, Thorsten, Sun, Jung-Hui, Taber, Matthew T, Taylor, Sarah J, Wong, Michael K, Zhang, Huiping, Lodge, Nicholas J, Bronson, Joanne J, Macor, John E, Gillman, Kevin W
Published in ACS chemical neuroscience (21.12.2016)
Published in ACS chemical neuroscience (21.12.2016)
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MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
Duncia, John V., Santella, Joseph B., Higley, C.Anne, Pitts, William J., Wityak, John, Frietze, William E., Rankin, F.Wayne, Sun, Jung-Hui, Earl, Richard A., Tabaka, A.Christine, Teleha, Christopher A., Blom, Karl F., Favata, Margaret F., Manos, Elizabeth J., Daulerio, Andrea J., Stradley, Deborah A., Horiuchi, Kurumi, Copeland, Robert A., Scherle, Peggy A., Trzaskos, James M., Magolda, Ronald L., Trainor, George L., Wexler, Ruth R., Hobbs, Frank W., Olson, Richard E.
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
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Synthesis of N-butyl side chain hydroxylated metabolites of roxifiban, a platelet glycoprotein IIB/IIIA receptor antagonist
Sun, JH, Emmett, GC, Hytrek, JL, Yan, JS, Tabaka-Blom, AC, Teleha, CA
Published in Heterocycles (01.07.2004)
Published in Heterocycles (01.07.2004)
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Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)‑1H‑pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Shi, Yan, Wang, Ying, Meng, Wei, Brigance, Robert P, Ryono, Denis E, Bolton, Scott, Zhang, Hao, Chen, Sean, Smirk, Rebecca, Tao, Shiwei, Tino, Joseph A, Williams, Kristin N, Sulsky, Richard, Nielsen, Laura, Ellsworth, Bruce, Wong, Michael K. Y, Sun, Jung-Hui, Leith, Leslie W, Sun, Dawn, Wu, Dauh-Rurng, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Chen, Bang-Chi, Wang, Aiying, Fuentes-Catanio, Helen G, Kunselman, Lori, Cap, Michael, Zalaznick, Jacob, Ma, Xiaohui, Liu, Heng, Taylor, Joseph R, Zebo, Rachel, Jones, Beverly, Kalinowski, Stephen, Swartz, Joann, Staal, Ada, O’Malley, Kevin, Kopcho, Lisa, Muckelbauer, Jodi K, Krystek, Stanley R, Spronk, Steven A, Marcinkeviciene, Jovita, Everlof, Gerry, Chen, Xue-Qing, Xu, Carrie, Li, Yi-Xin, Langish, Robert A, Yang, Yanou, Wang, Qi, Behnia, Kamelia, Fura, Aberra, Janovitz, Evan B, Pannacciulli, Nicola, Griffen, Steven, Zinker, Bradley A, Krupinski, John, Kirby, Mark, Whaley, Jean, Zahler, Robert, Barrish, Joel C, Robl, Jeffrey A, Cheng, Peter T. W
Published in Journal of medicinal chemistry (10.03.2022)
Published in Journal of medicinal chemistry (10.03.2022)
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Discovery of ((4-(5-(CyclopropylcarbamoyI)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38a MAP Kinase Inhibitor
Liu, Chunjian, Lin, James, Hynes, John, Wu, Hong, Wrobleski, Stephen T., Lin, Shuqun, Dhar, T. G. Murali, Vrudhula, Vivekananda M., Sun, Jung-Hui, Chao, Sam, Zhao, Rulin, Wang, Bei, Chen, Bang-Chi, Everlof, Gerry, Gesenberg, Christoph, Zhang, Hongjian, Marathe, Punit H., McIntyre, Kim W., Taylor, Tracy L., Gillooly, Kathleen, Shuster, David J., McKinnon, Murray, Dodd, John H., Barrish, Joel C., Schieven, Gary L., Leftheris, Katerina
Published in Journal of medicinal chemistry (08.10.2015)
Published in Journal of medicinal chemistry (08.10.2015)
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The synthesis and antitumor evaluation of unsymmetrical bis-imides
Cherney, Robert J., Swartz, Stephen G., Patten, Arthur D., Akamike, Emeka, Sun, Jung-Hui, Kaltenbach, Robert F., Seitz, Steven P., Behrens, Carl H., Getahun, Zelleka, Trainor, George L., Vavala, Mike, Kirshenbaum, Mindy R., Papp, Lisa M., Stafford, Margaret P., Czerniak, Philip M., Diamond, Richard J., McRipley, Ronald J., Page, Roni J., Gross, Janet L.
Published in Bioorganic & medicinal chemistry letters (21.01.1997)
Published in Bioorganic & medicinal chemistry letters (21.01.1997)
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Journal Article
Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2‑f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor
Liu, Chunjian, Lin, James, Hynes, John, Wu, Hong, Wrobleski, Stephen T., Lin, Shuqun, Dhar, T. G. Murali, Vrudhula, Vivekananda M., Sun, Jung-Hui, Chao, Sam, Zhao, Rulin, Wang, Bei, Chen, Bang-Chi, Everlof, Gerry, Gesenberg, Christoph, Zhang, Hongjian, Marathe, Punit H., McIntyre, Kim W., Taylor, Tracy L., Gillooly, Kathleen, Shuster, David J., McKinnon, Murray, Dodd, John H., Barrish, Joel C., Schieven, Gary L., Leftheris, Katerina
Published in Journal of medicinal chemistry (08.10.2015)
Published in Journal of medicinal chemistry (08.10.2015)
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