Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315
Jakob, Clarissa G, Upadhyay, Anup K, Donner, Pamela L, Nicholl, Emily, Addo, Sadiya N, Qiu, Wei, Ling, Christopher, Gopalakrishnan, Sujatha M, Torrent, Maricel, Cepa, Steven P, Shanley, Jason, Shoemaker, Alexander R, Sun, Chaohong C, Vasudevan, Anil, Woller, Kevin R, Shotwell, J. Brad, Shaw, Bailin, Bian, Zhiguo, Hutti, Jessica E
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Discovery of a Potent and Selective Covalent p300/CBP Inhibitor
Mastracchio, Anthony, Lai, Chunqiu, Digiammarino, Enrico, Ready, Damien B, Lasko, Loren M, Bromberg, Kenneth D, McClellan, William J, Montgomery, Debra, Manaves, Vlasios, Shaw, Bailin, Algire, Mikkel, Patterson, Melanie J, Sun, Chaohong C, Rosenberg, Saul, Lai, Albert, Michaelides, Michael R
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor
McDaniel, Keith F, Wang, Le, Soltwedel, Todd, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Mantei, Robert A, Pratt, John K, Sheppard, George S, Bui, Mai H, Faivre, Emily J, Huang, Xiaoli, Li, Leiming, Lin, Xiaoyu, Wang, Rongqi, Warder, Scott E, Wilcox, Denise, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Park, Chang H, Hutchins, Charles W, Shen, Jianwei J, Edalji, Rohinton P, Sun, Chaohong C, Martin, Ruth, Gao, Wenqing, Wong, Shekman, Fang, Guowei, Elmore, Steven W, Shen, Yu, Kati, Warren M
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis
Todorović, Viktor, Su, Zhi, Putman, C. Brent, Kakavas, Stevan J., Salte, Katherine M., McDonald, Heath A., Wetter, Joseph B., Paulsboe, Stephanie E., Sun, Qi, Gerstein, Clare E., Medina, Limary, Sielaff, Bernhard, Sadhukhan, Ramkrishna, Stockmann, Henning, Richardson, Paul L., Qiu, Wei, Argiriadi, Maria A., Henry, Rodger F., Herold, J. Martin, Shotwell, J. Brad, McGaraughty, Steve P., Honore, Prisca, Gopalakrishnan, Sujatha M., Sun, Chaohong C., Scott, Victoria E.
Published in Scientific reports (24.06.2019)
Published in Scientific reports (24.06.2019)
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