ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz, Sarah G, Jin, Sha, Khaw, Seong Lin, Kovar, Peter J, Lam, Lloyd T, Lee, Jackie, Maecker, Heather L, Marsh, Kennan C, Mason, Kylie D, Mitten, Michael J, Nimmer, Paul M, Oleksijew, Anatol, Park, Chang H, Park, Cheol-Min, Phillips, Darren C, Roberts, Andrew W, Sampath, Deepak, Seymour, John F, Smith, Morey L, Sullivan, Gerard M, Tahir, Stephen K, Tse, Chris, Wendt, Michael D, Xiao, Yu, Xue, John C, Zhang, Haichao, Humerickhouse, Rod A, Rosenberg, Saul H, Elmore, Steven W
Published in Nature medicine (01.02.2013)
Published in Nature medicine (01.02.2013)
Get full text
Journal Article
Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors
Wang, Le, Sullivan, Gerard M, Hexamer, Laura A, Hasvold, Lisa A, Thalji, Reema, Przytulinska, Magdalena, Tao, Zhi-Fu, Li, Gaoquan, Chen, Zehan, Xiao, Zhan, Gu, Wen-Zhen, Xue, John, Bui, Mai-Ha, Merta, Philip, Kovar, Peter, Bouska, Jennifer J, Zhang, Haiying, Park, Chang, Stewart, Kent D, Sham, Hing L, Sowin, Thomas J, Rosenberg, Saul H, Lin, Nan-Horng
Published in Journal of medicinal chemistry (23.08.2007)
Published in Journal of medicinal chemistry (23.08.2007)
Get full text
Journal Article
Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling
Song, Jung Min, Molla, Kalkidan, Anandharaj, Arunkumar, Cornax, Ingrid, O Sullivan, M Gerard, Kirtane, Ameya R, Panyam, Jayanth, Kassie, Fekadu
Published in Oncotarget (18.04.2017)
Published in Oncotarget (18.04.2017)
Get full text
Journal Article
Antitumor Activity of Orally Bioavailable Farnesyltransferase Inhibitor, ABT-100, Is Mediated by Antiproliferative, Proapoptotic, and Antiangiogenic Effects in Xenograft Models
Ferguson, Debra, Rodriguez, Luis E, Palma, Joann P, Refici, Marion, Jarvis, Kenneth, O'Connor, Jacqueline, Sullivan, Gerard M, Frost, David, Marsh, Kennan, Bauch, Joy, Zhang, Haiying, Lin, Nan-Horng, Rosenberg, Saul, Sham, Hing L, Joseph, Ingrid B J K
Published in Clinical cancer research (15.04.2005)
Published in Clinical cancer research (15.04.2005)
Get full text
Journal Article
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives
Gwaltney, Stephen L., O'Connor, Stephen J., Nelson, Lissa T.J., Sullivan, Gerard M., Imade, Hovis, Wang, Weibo, Hasvold, Lisa, Li, Qun, Cohen, Jerome, Gu, Wen-Zhen, Tahir, Stephen K., Bauch, Joy, Marsh, Kennan, Ng, Shi-Chung, Frost, David J., Zhang, Haiying, Muchmore, Steve, Jakob, Clarissa G., Stoll, Vincent, Hutchins, Charles, Rosenberg, Saul H., Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Get full text
Journal Article
ANTIBODY DRUG CONJUGATES WITH CELL-PERMEABLE Bcl-xL INHIBITORS
GEORGE DOHERTY, TAO ZHI-FU, ANDREW S JUDD, SONG XIAOHONG, DENNIE S WELCH, AARON R KUNZER, XILU WANG, SULLIVAN GERARD M, ANDREW J SOUERS, SCOTT L ACKLER, VIOLETA L MARIN, ERWIN R BOGHAERT, MILAN BRUNCKO
Year of Publication 24.09.2020
Get full text
Year of Publication 24.09.2020
Patent
Bcl-xL INHIBITORY COMPOUNDS HAVING LOW CELL PERMEABILITY AND ANTIBODY DRUG CONJUGATES INCLUDING THE SAME
GEORGE DOHERTY, ROBIN R FREY, TAO ZHI-FU, ANDREW S JUDD, SONG XIAOHONG, DENNIE S WELCH, AARON R KUNZER, XILU WANG, SULLIVAN GERARD M, STEVE C CULLEN, ANDREW J SOUERS, SHEN XIAOQIANG, VIOLETA L MARIN, SCOTT L ACKLER, WENDT MICHAEL D, HAIGHT ANTHONY R, ERWIN R BOGHAERT, NATHAN B BENNETT
Year of Publication 10.09.2020
Get full text
Year of Publication 10.09.2020
Patent
BCL-XL INHIBITORY COMPOUNDS AND ANTIBODY DRUG CONJUGATES INCLUDING THE SAME
GEORGE DOHERTY, ROBIN R FREY, TAO ZHI-FU, ANDREW S JUDD, SONG XIAOHONG, DENNIE S WELCH, AARON R KUNZER, XILU WANG, SULLIVAN GERARD M, STEVE C CULLEN, ANDREW J SOUERS, SHEN XIAOQIANG, SCOTT L ACKLER, WENDT MICHAEL D, HAIGHT ANTHONY R, ERWIN R BOGHAERT, NATHAN B BENNETT
Year of Publication 27.08.2020
Get full text
Year of Publication 27.08.2020
Patent
Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation
Hasvold, Lisa A., Wang, Weibo, Gwaltney, Stephen L., Rockway, Todd W., Nelson, Lissa T.J., Mantei, Robert A., Fakhoury, Stephen A., Sullivan, Gerard M., Li, Qun, Lin, Nan-Horng, Wang, Le, Zhang, Haiying, Cohen, Jerome, Gu, Wen-Zhen, Marsh, Kennan, Bauch, Joy, Rosenberg, Saul, Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Get full text
Journal Article
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency
Gwaltney, Stephen L., O'Connor, Stephen J., Nelson, Lissa T.J., Sullivan, Gerard M., Imade, Hovis, Wang, Weibo, Hasvold, Lisa, Li, Qun, Cohen, Jerome, Gu, Wen-Zhen, Tahir, Stephen K., Bauch, Joy, Marsh, Kennan, Ng, Shi-Chung, Frost, David J., Zhang, Haiying, Muchmore, Steve, Jakob, Clarissa G., Stoll, Vincent, Hutchins, Charles, Rosenberg, Saul H., Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Get full text
Journal Article
8-CARBAMOYL-2-(2,3-DISUBSTITUTED PYRID-6-YL)-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS-INDUCING AGENTS FOR TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
GEORGE DOHERTY, TAO ZHI-FU, SONG XIAOHONG, ANDREW SOUERS, AARON R KUNZER, LE WANG, XILU WANG, ANDREW JUDD, TODD M HANSEN, SULLIVAN GERARD M, ROBIN FREY, WENDT MICHAEL D, MILAN BRUNCKO
Year of Publication 02.11.2017
Get full text
Year of Publication 02.11.2017
Patent
A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies
Gu, Wen-Zhen, Joseph, Ingrid, Wang, Yi-Chun, Frost, David, Sullivan, Gerard M, Wang, Le, Lin, Nan-Horng, Cohen, Jerry, Stoll, Vincent S, Jakob, Clarissa G, Muchmore, Steven W, Harlan, John E, Holzman, Tom, Walten, Karl A, Ladror, Uri S, Anderson, Mark G, Kroeger, Paul, Rodriguez, Luis E, Jarvis, Kenneth P, Ferguson, Debra, Marsh, Kennan, Ng, Shichung, Rosenberg, Saul H, Sham, Hing L, Zhang, Haiying
Published in Anti-cancer drugs (01.11.2005)
Published in Anti-cancer drugs (01.11.2005)
Get more information
Journal Article
APOPTOSIS INDUCING AGENT FOR TREATMENT OF CANCER, IMMUNOLOGICAL DISEASES AND AUTOIMMUNE DISEASES
GEORGE DOHERTY, TAO ZHI-FU, SONG XIAOHONG, ANDREW SOUERS, AARON R KUNZER, LE WANG, XILU WANG, ANDREW JUDD, TODD M HANSEN, SULLIVAN GERARD M, ROBIN FREY, WENDT MICHAEL D, MILAN BRUNCKO
Year of Publication 30.03.2017
Get full text
Year of Publication 30.03.2017
Patent
BCL XL BCL XL INHIBITORY COMPOUNDS HAVING LOW CELL PERMEABILITY AND ANTIBODY DRUG CONJUGATES INCLUDING THE SAME
CULLEN STEVE C, WELCH DENNIE S, SONG XIAOHONG, BENNETT NATHAN B, DOHERTY GEORGE, BOGHAERT ERWIN R, SULLIVAN GERARD M, MARIN VIOLETA L, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, SHEN XIAOQIANG, WENDT MICHAEL D, HAIGHT ANTHONY R, KUNZER AARON R, FREY ROBIN R, ACKLER SCOTT L, JUDD ANDREW S
Year of Publication 16.08.2017
Get full text
Year of Publication 16.08.2017
Patent
Sulfonamide derivatives as Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, PARK, CHEOL MIN, WANG LE, SONG XIAOHONG, ELMORE STEVEN W, BRUNCKO MILAN, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, TAO ZHI FU, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 18.01.2017
Get full text
Year of Publication 18.01.2017
Patent
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, PARK, CHEOL MIN, WANG LE, DAI YUJIA, SONG XIAOHONG, ELMORE STEVEN W, BRUNCKO MILAN, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, TAO ZHI FU, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 07.12.2016
Get full text
Year of Publication 07.12.2016
Patent
APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
JUDD ANDREW, HANSEN TODD M, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, SOUERS ANDREW, SULLIVAN GERARD M, WANG XILU, TAO ZHI FU, FREY ROBIN, WENDT MICHAEL D, BRUNKO MILAN, KUNZER AARON R
Year of Publication 04.07.2014
Get full text
Year of Publication 04.07.2014
Patent
8-CARBAMOYL-2-(2,3-DISUBSTITUTED PYRID-6-YL)-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
JUDD ANDREW, HANSEN TODD M, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, SOUERS ANDREW, SULLIVAN GERARD M, WANG XILU, TAO ZHI FU, FREY ROBIN, WENDT MICHAEL D, BRUNKO MILAN, KUNZER AARON R
Year of Publication 19.06.2014
Get full text
Year of Publication 19.06.2014
Patent