Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2
Sudom, Athena, Talreja, Santosh, Danao, Jean, Bragg, Eric, Kegel, Rob, Min, Xiaoshan, Richardson, Jason, Zhang, Zhongqi, Sharkov, Nikolai, Marcora, Edoardo, Thibault, Steve, Bradley, Jodi, Wood, Steve, Lim, Ai-Ching, Chen, Hang, Wang, Songli, Foltz, Ian N., Sambashivan, Shilpa, Wang, Zhulun
Published in The Journal of biological chemistry (10.08.2018)
Published in The Journal of biological chemistry (10.08.2018)
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Journal Article
Next generation Fc scaffold for multispecific antibodies
Estes, Bram, Sudom, Athena, Gong, Danyang, Whittington, Douglas A., Li, Vivian, Mohr, Christopher, Li, Danqing, Riley, Timothy P., Shi, Stone D.-H., Zhang, Jun, Garces, Fernando, Wang, Zhulun
Published in iScience (17.12.2021)
Published in iScience (17.12.2021)
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Journal Article
Cytotoxic Activities of Mannich Bases of Chalcones and Related Compounds
Dimmock, Jonathan R, Kandepu, N. Murthi, Hetherington, Mark, Quail, J. Wilson, Pugazhenthi, Uma, Sudom, Athena M, Chamankhah, Mahmood, Rose, Patricia, Pass, Eric, Allen, Theresa M, Halleran, Sarah, Szydlowski, Jen, Mutus, Bulent, Tannous, Marie, Manavathu, Elias K, Myers, Timothy G, De Clercq, Erik, Balzarini, Jan
Published in Journal of medicinal chemistry (26.03.1998)
Published in Journal of medicinal chemistry (26.03.1998)
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Journal Article
Structure/function studies of phosphoryl transfer by phosphoenolpyruvate carboxykinase
Delbaere, Louis T.J., Sudom, Athena M., Prasad, Lata, Leduc, Yvonne, Goldie, Hughes
Published in BBA - Proteins and Proteomics (11.03.2004)
Published in BBA - Proteins and Proteomics (11.03.2004)
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Book Review
Journal Article
Mechanisms of Activation of Phosphoenolpyruvate Carboxykinase from Escherichia coli by Ca2+ and of Desensitization by Trypsin
Sudom, Athena, Walters, Robert, Pastushok, Landon, Goldie, Douglas, Prasad, Lata, Delbaere, Louis T J, Goldie, Hughes
Published in Journal of Bacteriology (01.07.2003)
Published in Journal of Bacteriology (01.07.2003)
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Journal Article
Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation
Kielczewska, Agnieszka, D'Angelo, Igor, Amador, Maria Sheena, Wang, Tina, Sudom, Athena, Min, Xiaoshan, Rathanaswami, Palaniswami, Pigott, Craig, Foltz, Ian N.
Published in The Journal of biological chemistry (01.02.2022)
Published in The Journal of biological chemistry (01.02.2022)
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Journal Article
Imidazolone as an Amide Bioisostere in the Development of β‑1,3‑N‑Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors
Jackson, Jeffrey J., Siegmund, Aaron C., Bai, Wen-Ju, Reed, Anthony B., Birkholz, Adam B., Campuzano, Iain D. G., Créquer-Grandhomme, Amandine, Hu, Ruozhen, Modak, Rucha V., Sudom, Athena, Javier, Noelle, Sanders, Christiana, Lo, Mei-Chu, Xie, Fang, Cee, Victor J., Manzanillo, Paolo, Allen, John G.
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
4-(β-Arylvinyl)-3-(β-arylvinylketo)-1-ethyl-4-piperidinols and Related Compounds: A Novel Class of Cytotoxic and Anticancer Agents
Dimmock, Jonathan R, Vashishtha, Sarvesh C, Quail, J. Wilson, Pugazhenthi, Uma, Zimpel, Zbigniew, Sudom, Athena M, Allen, Theresa M, Kao, Grace Y, Balzarini, Jan, De Clercq, Erik
Published in Journal of medicinal chemistry (08.10.1998)
Published in Journal of medicinal chemistry (08.10.1998)
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Journal Article
Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation
Liu, Jinsong, Sudom, Athena, Min, Xiaoshan, Cao, Zhaodan, Gao, Xiong, Ayres, Merrill, Lee, Fei, Cao, Ping, Johnstone, Sheree, Plotnikova, Olga, Walker, Nigel, Chen, Guoqing, Wang, Zhulun
Published in The Journal of biological chemistry (10.08.2012)
Published in The Journal of biological chemistry (10.08.2012)
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Journal Article
Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies
Mock, Marissa, Jacobitz, Alex W., Langmead, Christopher James, Sudom, Athena, Yoo, Daniel, Humphreys, Sara C., Alday, Mai, Alekseychyk, Larysa, Angell, Nicolas, Bi, Vivian, Catterall, Hannah, Chen, Chen-Chun, Chou, Hui-Ting, Conner, Kip P., Cook, Kevin D., Correia, Ana R., Dykstra, Andrew, Ghimire-Rijal, Sudipa, Graham, Kevin, Grandsard, Peter, Huh, Joon, Hui, John O., Jain, Mani, Jann, Victoria, Jia, Lei, Johnstone, Sheree, Khanal, Neelam, Kolvenbach, Carl, Narhi, Linda, Padaki, Rupa, Pelegri-O’Day, Emma M., Qi, Wei, Razinkov, Vladimir, Rice, Austin J., Smith, Richard, Spahr, Christopher, Stevens, Jennitte, Sun, Yax, Thomas, Veena A., van Driesche, Sarah, Vernon, Robert, Wagner, Victoria, Walker, Kenneth W., Wei, Yangjie, Winters, Dwight, Yang, Melissa, Campuzano, Iain D. G.
Published in mAbs (31.12.2023)
Published in mAbs (31.12.2023)
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Journal Article
AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys
Goldstein, Rebecca L., Goyos, Ana, Li, Chi-Ming, Deegen, Petra, Bogner, Pamela, Sternjak, Alexander, Thomas, Oliver, Klinger, Matthias, Wahl, Joachim, Friedrich, Matthias, Rattel, Benno, Lamas, Edwin, Min, Xiaoshan, Sudom, Athena, Farshbaf, Mozhgan, Coxon, Angela, Balazs, Mercedesz, Arvedson, Tara
Published in Blood advances (08.09.2020)
Published in Blood advances (08.09.2020)
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Journal Article
Crystal Structures of IRAK-4 Kinase in Complex with Inhibitors: A Serine/Threonine Kinase with Tyrosine as a Gatekeeper
Wang, Zhulun, Liu, Jinsong, Sudom, Athena, Ayres, Merrill, Li, Shyun, Wesche, Holger, Powers, Jay P., Walker, Nigel P.C.
Published in Structure (London) (01.12.2006)
Published in Structure (London) (01.12.2006)
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Journal Article
Inhibiting NF-κB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure–activity relationship, and co-crystal structures
Li, Kexue, McGee, Lawrence R., Fisher, Ben, Sudom, Athena, Liu, Jinsong, Rubenstein, Steven M., Anwer, Mohmed K., Cushing, Timothy D., Shin, Youngsook, Ayres, Merrill, Lee, Fei, Eksterowicz, John, Faulder, Paul, Waszkowycz, Bohdan, Plotnikova, Olga, Farrelly, Ellyn, Xiao, Shou-Hua, Chen, Guoqing, Wang, Zhulun
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Journal Article
Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4
Wang, Zhulun, Sun, Daqing, Johnstone, Sheree, Cao, Zhaodan, Gao, Xiong, Jaen, Juan C., Liu, Jingqian, Lively, Sarah, Miao, Shichang, Sudom, Athena, Tomooka, Craig, Walker, Nigel P.C., Wright, Matthew, Yan, Xuelei, Ye, Qiuping, Powers, Jay P.
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
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Journal Article
Identification of a PPARδ agonist with partial agonistic activity on PPARγ
Connors, Richard V., Wang, Zhulun, Harrison, Martin, Zhang, Alex, Wanska, Malgorzata, Hiscock, Steve, Fox, Brian, Dore, Michael, Labelle, Marc, Sudom, Athena, Johnstone, Sheree, Liu, Jinsong, Walker, Nigel P.C., Chai, Anne, Siegler, Karen, Li, Yang, Coward, Peter
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Journal Article
An Inhibitory Antibody against Dipeptidyl Peptidase IV Improves Glucose Tolerance in Vivo
Tang, Jie, Majeti, Jiangwen, Sudom, Athena, Xiong, Yumei, Lu, Mei, Liu, Qiang, Higbee, Jared, Zhang, Yi, Wang, Yan, Wang, Wei, Cao, Ping, Xia, Zhen, Johnstone, Sheree, Min, Xiaoshan, Yang, Xiaoping, Shao, Hui, Yu, Timothy, Sharkov, Nik, Walker, Nigel, Tu, Hua, Shen, Wenyan, Wang, Zhulun
Published in The Journal of biological chemistry (11.01.2013)
Published in The Journal of biological chemistry (11.01.2013)
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Journal Article
Discovery of Novel, Potent Benzamide Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Exhibiting Oral Activity in an Enzyme Inhibition ex Vivo Model
Julian, Lisa D, Wang, Zhulun, Bostick, Tracy, Caille, Seb, Choi, Rebekah, DeGraffenreid, Michael, Di, Yongmei, He, Xiao, Hungate, Randall W, Jaen, Juan C, Liu, Jinsong, Monshouwer, Mario, McMinn, Dustin, Rew, Yosup, Sudom, Athena, Sun, Daqing, Tu, Hua, Ursu, Stefania, Walker, Nigel, Yan, Xuelei, Ye, Qiuping, Powers, Jay P
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Journal Article
Distinctive molecular inhibition mechanisms for selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1
Tu, Hua, Powers, Jay P., Liu, Jinsong, Ursu, Stefania, Sudom, Athena, Yan, Xuelei, Xu, Haoda, Meininger, David, DeGraffenreid, Michael, He, Xiao, Jaen, Juan C., Sun, Daqing, Labelle, Marc, Yamamoto, Hiroshi, Shan, Bei, Walker, Nigel P.C., Wang, Zhulun
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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Journal Article
Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)
Sun, Daqing, Wang, Zhulun, Di, Yongmei, Jaen, Juan C., Labelle, Marc, Ma, Ji, Miao, Shichang, Sudom, Athena, Tang, Liang, Tomooka, Craig S., Tu, Hua, Ursu, Stefania, Walker, Nigel, Yan, Xuelei, Ye, Qiuping, Powers, Jay P.
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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Journal Article