N -Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal β-Glucocerebrosidase
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Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C -5a-Substituted Derivatives of 4- epi -Isofagomine
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DLHex-DGJ, a novel derivative of 1-deoxygalactonojirimycin with pharmacological chaperone activity in human G(M1)-gangliosidosis fibroblasts
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Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
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Fluorous iminoalditols act as effective pharmacological chaperones against gene products from GLB1 alleles causing GM1-gangliosidosis and Morquio B disease
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Fluorous Iminoalditols: A New Family of Glycosidase Inhibitors and Pharmacological Chaperones
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Published in Chembiochem : a European journal of chemical biology (24.09.2010)
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The Structural Basis of Glycosidase Inhibition by Five-Membered Iminocyclitols: The Clan A Glycoside Hydrolase Endoglycoceramidase as a Model System
Caines, Matthew E. C., Hancock, Susan M., Tarling, Chris A., Wrodnigg, Tanja M., Stick, Robert V., Stütz, Arnold E., Vasella, Andrea, Withers, Stephen G., Strynadka, Natalie C. J.
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Published in Angewandte Chemie International Edition (01.01.2007)
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Diaminocyclopentane-derived O -GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease
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Schitter, Georg, Scheucher, Elisabeth, Steiner, Andreas J, Stütz, Arnold E, Thonhofer, Martin, Tarling, Chris A, Withers, Stephen G, Wicki, Jacqueline, Fantur, Katrin, Paschke, Eduard, Mahuran, Don J, Rigat, Brigitte A, Tropak, Michael, Wrodnigg, Tanja M
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Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study
Prasch, Herwig, Wolfsgruber, Andreas, Thonhofer, Martin, Culum, Andre, Mandl, Christoph, Weber, Patrick, Zuendel, Melanie, Nasseri, Seyed A., Gonzalez Santana, Andres, Tegl, Gregor, Nidetzky, Bernd, Gruber, Karl, Stuetz, Arnold E., Withers, Stephen G., Wrodnigg, Tanja M.
Published in Chembiochem : a European journal of chemical biology (01.12.2023)
Published in Chembiochem : a European journal of chemical biology (01.12.2023)
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Diaminocyclopentane – l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase
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Published in Bioorganic chemistry (01.07.2024)
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Published in RSC advances (29.04.2021)
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Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase
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Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C
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Published in Carbohydrate research (24.06.2016)
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