A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in Patients with BRAF-Mutant Cancers Using Pharmacokinetics-Informed Dose Escalation
Yaeger, Rona, McKean, Meredith A, Haq, Rizwan, Beck, J Thaddeus, Taylor, Matthew H, Cohen, Jonathan E, Bowles, Daniel W, Gadgeel, Shirish M, Mihalcioiu, Catalin, Papadopoulos, Kyriakos P, Diamond, Eli L, Sturtz, Keren B, Feng, Gang, Drescher, Stefanie K, Reddy, Micaela B, Sengupta, Bhaswati, Maity, Arnab K, Brown, Suzy A, Singh, Anurag, Brown, Eric N, Baer, Brian R, Wong, Jim, Mou, Tung-Chung, Wu, Wen-I, Kahn, Dean R, Gadal, Sunyana, Rosen, Neal, Gaudino, John J, Lee, Patrice A, Hartley, Dylan P, Rothenberg, S Michael
Published in Cancer discovery (04.09.2024)
Published in Cancer discovery (04.09.2024)
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Abstract CT178: Phase 1 trial of PF-07799933 (ARRY-440), a next-generation BRAF inhibitor, for BRAF-mutant cancers
Yaeger, Rona, McKean, Meredith, Haq, Rizwan, Beck, Joseph T., Taylor, Matthew H., Cohen, Jonathan, Bowles, Daniel, Gadgeel, Shirish M., Mihalcioiu, Catalin, Papadopoulos, Kyriakos P., Diamond, Eli L., Sturtz, Keren B., Feng, Gang, Drescher, Stefanie K., Reddy, Micaela B., Sengupta, Bhaswati, Maity, Arnab K., Brown, Suzy A., Singh, Anurag, Brown, Eric N., Baer, Brian R., Wong, Jim, Mou, Tung-Chung, Wu, Wen I., Kahn, Dean, Gadal, Sunyana, Rosen, Neal, Gaudino, John J., Lee, Patrice A., Hartley, Dylan P., Rothenberg, Stephen Michael
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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