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Steiner, Andreas J., Schitter, Georg, Stütz, Arnold E., Wrodnigg, Tanja M., Tarling, Chris A., Withers, Stephen G., Fantur, Katrin, Mahuran, Don, Paschke, Eduard, Tropak, Michael
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Synthesis and biological evaluation of novel biotin–iminoalditol conjugates
Pototschnig, Gerit, De Csáky, Christian Morales, Montenegro Burke, Jose R., Schitter, Georg, Stütz, Arnold E., Tarling, Chris A., Withers, Stephen G., Wrodnigg, Tanja M.
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
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A concise synthetic approach for isoiminosugars
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Published in Carbohydrate research (01.10.2024)
Published in Carbohydrate research (01.10.2024)
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Diaminocyclopentane-derived O -GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease
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Published in Chemical communications (Cambridge, England) (04.08.2022)
Published in Chemical communications (Cambridge, England) (04.08.2022)
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Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study
Prasch, Herwig, Wolfsgruber, Andreas, Thonhofer, Martin, Culum, Andre, Mandl, Christoph, Weber, Patrick, Zuendel, Melanie, Nasseri, Seyed A., Gonzalez Santana, Andres, Tegl, Gregor, Nidetzky, Bernd, Gruber, Karl, Stuetz, Arnold E., Withers, Stephen G., Wrodnigg, Tanja M.
Published in Chembiochem : a European journal of chemical biology (01.12.2023)
Published in Chembiochem : a European journal of chemical biology (01.12.2023)
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A remarkable change in inhibition potency and selectivity of isofagomine by simple N-modification
Culum, André, Prasch, Herwig, Dorn, Tobias, Fischer, Roland, Gardić, Ema, Schmutz, Franziska, Steinbrugger, Magdalena, Stütz, Arnold E., Weber, Patrick, Wrodnigg, Tanja M., Thonhofer, Martin
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Published in Monatshefte für Chemie (29.05.2024)
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Diaminocyclopentane – l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase
Weber, Patrick, Bojarová, Pavla, Brouzdová, Jitka, Křen, Vladimír, Kulik, Natalia, Stütz, Arnold E., Thonhofer, Martin, Wrodnigg, Tanja M.
Published in Bioorganic chemistry (01.07.2024)
Published in Bioorganic chemistry (01.07.2024)
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N‐Methyl‐N‐Alkylaminocyclopentanes: Powerful and Selective β‐d‐Glucocerebrosidase Inhibitors
Weber, Patrick, Fischer, Roland, Nasseri, Seyed A., Pabst, Bettina M., Prasch, Herwig, Stütz, Arnold E., Thonhofer, Martin, Withers, Stephen G., Windischhofer, Werner, Wrodnigg, Tanja M.
Published in Helvetica chimica acta (01.04.2024)
Published in Helvetica chimica acta (01.04.2024)
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New α-galactosidase-inhibiting aminohydroxycyclopentanes
Weber, Patrick, Fischer, Roland, Nasseri, Seyed A, Stütz, Arnold E, Thonhofer, Martin, Withers, Stephen G, Wolfsgruber, Andreas, Wrodnigg, Tanja M
Published in RSC advances (29.04.2021)
Published in RSC advances (29.04.2021)
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Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable beta-galactosidase inhibitors and activity promotors of G(M1)-gangliosidosis related human lysosomal beta-galactosidase mutant R201C
Thonhofer, Martin, Weber, Patrick, Santana, Andres Gonzalez, Tysoe, Christina, Fischer, Roland, Pabst, Bettina M., Paschke, Eduard, Schalli, Michael, Stuetz, Arnold E., Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G.
Published in Carbohydrate research (24.06.2016)
Published in Carbohydrate research (24.06.2016)
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A new type of pharmacological chaperone for G(M1)-gangliosidosis related human lysosomal beta-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols
Schalli, Michael, Weber, Patrick, Tysoe, Christina, Pabst, Bettina M., Thonhofer, Martin, Paschke, Eduard, Stuetz, Arnold E., Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G.
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
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Synthesis of modified 1,5-imino-d-xylitols as ligands for lysosomal -glucocerebrosidase
Zoidl, Manuel, Wolfsgruber, Andreas, Schalli, Michael, Nasseri, Seyed A., Weber, Patrick, Stuetz, Arnold E., Withers, Stephen G., Wrodnigg, Tanja M.
Published in Monatshefte für Chemie (01.05.2019)
Published in Monatshefte für Chemie (01.05.2019)
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5-Fluoro derivatives of 4-epi-isofagomine as D-galactosidase inhibitors and potential pharmacological chaperones for G(M1)-gangliosidosis as well as Fabry's disease
Thonhofer, Martin, Santana, Andres Gonzalez, Fischer, Roland, Gomez, Ana Torvisco, Saf, Robert, Schalli, Michael, Stuetz, Arnold E., Withers, Stephen G.
Published in Carbohydrate research (01.02.2016)
Published in Carbohydrate research (01.02.2016)
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Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase
Weber, Patrick, Mészáros, Zuzana, Bojarová, Pavla, Ebner, Manuel, Fischer, Roland, Křen, Vladimír, Kulik, Natalia, Müller, Philipp, Vlachová, Miluše, Slámová, Kristýna, Stütz, Arnold E., Thonhofer, Martin, Torvisco, Ana, Wrodnigg, Tanja M., Wolfsgruber, Andreas
Published in Bioorganic chemistry (01.11.2023)
Published in Bioorganic chemistry (01.11.2023)
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Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful beta-galactosidase inhibitors and low concentration activators of G(M1)-gangliosidosis-related human lysosomal beta-galactosidase
Thonhofer, Martin, Weber, Patrick, Santana, Andres Gonzalez, Fischer, Roland, Pabst, Bettina M., Paschke, Eduard, Schalli, Michael, Stuetz, Arnold E., Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G.
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
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A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors
Lebl, René, Thonhofer, Martin, Tysoe, Christina, Pabst, Bettina M., Schalli, Michael, Weber, Patrick, Paschke, Eduard, Stütz, Arnold E., Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G.
Published in Carbohydrate research (10.04.2017)
Published in Carbohydrate research (10.04.2017)
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From secondary alcohols to tertiary fluoro substituents: A simple route to hydroxymethyl branched sugars with a fluorine substituent at the branching point
Schalli, Michael, Thonhofer, Martin, Wolfsgruber, Andreas, Weber, Hansjörg, Fischer, Roland, Saf, Robert, Stütz, Arnold E.
Published in Carbohydrate research (21.12.2016)
Published in Carbohydrate research (21.12.2016)
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Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase
Thompson, Andrew J, Williams, Rohan J, Hakki, Zalihe, Alonzi, Dominic S, Wennekes, Tom, Gloster, Tracey M, Songsrirote, Kriangsak, Thomas-Oates, Jane E, Wrodnigg, Tanja M, Spreitz, Josef, Stütz, Arnold E, Butters, Terry D, Williams, Spencer J, Davies, Gideon J
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2012)
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C-5a-substituted validamine type glycosidase inhibitors
Schalli, Michael, Wolfsgruber, Andreas, Gonzalez Santana, Andres, Tysoe, Christina, Fischer, Roland, Stütz, Arnold E., Thonhofer, Martin, Withers, Stephen G.
Published in Carbohydrate research (22.02.2017)
Published in Carbohydrate research (22.02.2017)
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