Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing
Moussa, Hagar F., Bsteh, Daniel, Yelagandula, Ramesh, Pribitzer, Carina, Stecher, Karin, Bartalska, Katarina, Michetti, Luca, Wang, Jingkui, Zepeda-Martinez, Jorge A., Elling, Ulrich, Stuckey, Jacob I., James, Lindsey I., Frye, Stephen V., Bell, Oliver
Published in Nature communications (29.04.2019)
Published in Nature communications (29.04.2019)
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Journal Article
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
Stuckey, Jacob I, Dickson, Bradley M, Cheng, Nancy, Liu, Yanli, Norris, Jacqueline L, Cholensky, Stephanie H, Tempel, Wolfram, Qin, Su, Huber, Katherine G, Sagum, Cari, Black, Karynne, Li, Fengling, Huang, Xi-Ping, Roth, Bryan L, Baughman, Brandi M, Senisterra, Guillermo, Pattenden, Samantha G, Vedadi, Masoud, Brown, Peter J, Bedford, Mark T, Min, Jinrong, Arrowsmith, Cheryl H, James, Lindsey I, Frye, Stephen V
Published in Nature chemical biology (01.03.2016)
Published in Nature chemical biology (01.03.2016)
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Journal Article
Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
Lamb, Kelsey N, Bsteh, Daniel, Dishman, Sarah N, Moussa, Hagar F, Fan, Huitao, Stuckey, Jacob I, Norris, Jacqueline L, Cholensky, Stephanie H, Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z, Bedford, Mark T, Pearce, Kenneth H, Kenakin, Terry P, Kireev, Dmitri B, Wang, Gang Greg, James, Lindsey I, Bell, Oliver, Frye, Stephen V
Published in Cell chemical biology (17.10.2019)
Published in Cell chemical biology (17.10.2019)
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Journal Article
Structure–Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains
Stuckey, Jacob I, Simpson, Catherine, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Lee, Junghyun, Pasca, Ryan, Cheng, Nancy, Dickson, Bradley M, Pearce, Kenneth H, Frye, Stephen V, James, Lindsey I
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Journal Article
Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing
Barnash, Kimberly D, Lamb, Kelsey N, Stuckey, Jacob I, Norris, Jacqueline L, Cholensky, Stephanie H, Kireev, Dmitri B, Frye, Stephen V, James, Lindsey I
Published in ACS chemical biology (16.09.2016)
Published in ACS chemical biology (16.09.2016)
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Journal Article
Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2
Barnash, Kimberly D, The, Juliana, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Worley, Beau M, Li, Fengling, Stuckey, Jacob I, Brown, Peter J, Vedadi, Masoud, Arrowsmith, Cheryl H, Frye, Stephen V, James, Lindsey I
Published in ACS combinatorial science (13.03.2017)
Published in ACS combinatorial science (13.03.2017)
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Journal Article
Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers
Keller, Patricia J, Adams, Elizabeth J, Wu, Rentian, Côté, Alexandre, Arora, Shilpi, Cantone, Nico, Meyer, Rosana, Mertz, Jennifer A, Gehling, Victor, Cui, Jike, Stuckey, Jacob I, Khanna, Avinash, Zhao, Feng, Chen, Zehua, Yu, Ziyang, Cummings, Richard T, Taimi, Mohammed, Lakhani, Nehal J, Rasco, Drew, Gutierrez, Martin, Duska, Linda, Devitt, Michael, Rippley, Ronda, Levell, Julian, Truong, Jennifer, Wang, Jing, Sun, Kaiming, Trojer, Patrick
Published in Cancer research (Chicago, Ill.) (01.08.2024)
Published in Cancer research (Chicago, Ill.) (01.08.2024)
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Journal Article
Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity
Stuckey, Jacob I., Cantone, Nico R., Côté, Alexandre, Arora, Shilpi, Vivat, Valerie, Ramakrishnan, Ashwin, Mertz, Jennifer A., Khanna, Avinash, Brenneman, Jehrod, Gehling, Victor S., Moine, Ludivine, Sims, Robert J., Audia, James E., Trojer, Patrick, Levell, Julian R., Cummings, Richard T.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Journal Article
Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time
Khanna, Avinash, Cote, Alexandre, Arora, Shilpi, Moine, Ludivine, Gehling, Victor S., Brenneman, Jehrod, Cantone, Nico, Stuckey, Jacob, Apte, Shruti, Ramakrishnan, Ashwin, Bruderek, Kamil, Bradley, William D., Audia, James E., Cummings, Richard T., Sims, Robert J., Trojer, Patrick, Levell, Julian R.
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Journal Article
Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1
Suh, Junghyun L, Watts, Brian, Stuckey, Jacob I, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Dickson, Bradley M, An, Yi, Mathea, Sebastian, Salah, Eidarus, Knapp, Stefan, Khan, Abid, Adams, Alexander T, Strahl, Brian D, Sagum, Cari A, Bedford, Mark T, James, Lindsey I, Kireev, Dmitri B, Frye, Stephen V
Published in Biochemistry (Easton) (10.04.2018)
Published in Biochemistry (Easton) (10.04.2018)
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Journal Article
Correction to “Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID subunit 1”
Suh, Junghyun L, Watts, Brian, Stuckey, Jacob I, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Dickson, Bradley M, An, Yi, Mathea, Sebastian, Salah, Eidarus, Knapp, Stefan, Khan, Abid, Adams, Alexander T, Strahl, Brian D, Sagum, Cari A, Bedford, Mark T, James, Lindsey I, Kireev, Dmitri B, Frye, Stephen V
Published in Biochemistry (Easton) (11.12.2018)
Published in Biochemistry (Easton) (11.12.2018)
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Journal Article
메틸 변형 효소 조절제, 이의 조성물 및 용도
STUCKEY JACOB I, GEHLING VICTOR S, KHANNA AVINASH, MOINE LUDIVINE, COTE ALEXANDRE
Year of Publication 11.01.2021
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Year of Publication 11.01.2021
Patent
Abstract ND08: Discovery of FX-909, a first-in-class inverse agonist of the peroxisome proliferator-activated receptor gamma (PPARG) lineage transcription factor, to potentially treat patients with the luminal subtype of advanced urothelial cancer (UC)
Sims, Robert, Mertz, Jennifer A., Wilson, Jonathan E., Audia, James E., Williamson, Kaylyn E., Li, Yong, Kuljanin, Miljan, Motely, Will W., DeLaBarre, Byron, Bowden, Michaela, Stuckey, Jacob I.
Published in Cancer research (Chicago, Ill.) (29.05.2023)
Published in Cancer research (Chicago, Ill.) (29.05.2023)
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Journal Article
Discovery and Characterization of a Cellularly Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
Lamb, Kelsey N., Bsteh, Daniel, Dishman, Sarah N., Moussa, Hagar F., Fan, Huitao, Stuckey, Jacob I., Norris, Jacqueline L., Cholensky, Stephanie H., Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z., Bedford, Mark T., Pearce, Kenneth H., Kenakin, Terry P., Kireev, Dmitri B., Wang, Gang Greg, James, Lindsey I., Bell, Oliver, Frye, Stephen V.
Published in Cell chemical biology (15.08.2019)
Published in Cell chemical biology (15.08.2019)
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Journal Article
Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
Stuckey, Jacob I, Dickson, Bradley M, Cheng, Nancy, Liu, Yanli, Norris, Jacqueline L, Cholensky, Stephanie H, Tempel, Wolfram, Qin, Su, Huber, Katherine G, Sagum, Cari, Black, Karynne, Li, Fengling, Huang, Xi-Ping, Roth, Bryan L, Baughman, Brandi M, Senisterra, Guillermo, Pattenden, Samantha G, Vedadi, Masoud, Brown, Peter J, TBedford, Mark, Min, Jinrong, Arrowsmith, Cheryl H, James, Lindsey I, Frye, Stephen V
Published in Nature chemical biology (01.08.2019)
Published in Nature chemical biology (01.08.2019)
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Journal Article
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
Gehling, Victor, S, Stuckey, Jacob, I, Côté, Alexandre, Moine, Ludivine, Khanna, Avinash
Year of Publication 13.09.2024
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Year of Publication 13.09.2024
Patent
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
COTE Alexandre, STUCKEY Jacob I, KHANNA Avinash, GEHLING Victor S, MOINE Ludivine
Year of Publication 30.08.2024
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Year of Publication 30.08.2024
Patent