Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613
Guardado Rivas, Moises O, Stuart, Shawn D, Thach, Daniel, Dahan, Michael, Shorr, Robert, Zachar, Zuzana, Bingham, Paul M
Published in PloS one (08.06.2022)
Published in PloS one (08.06.2022)
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Journal Article
A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process
Stuart, Shawn D, Schauble, Alexandra, Gupta, Sunita, Kennedy, Adam D, Keppler, Brian R, Bingham, Paul M, Zachar, Zuzana
Published in Cancer & metabolism (10.03.2014)
Published in Cancer & metabolism (10.03.2014)
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Journal Article
Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo
ZACHAR, Zuzana, MARECEK, James, LEE, King, RODRIGUEZ, Robert, SHORR, Robert, BINGHAM, Paul M, MATURO, Claudia, GUPTA, Sunita, STUART, Shawn D, HOWELL, Katy, SCHAUBLE, Alexandra, LEM, Joanna, PIRAMZADIAN, Arin, KARNIK, Sameer
Published in Journal of molecular medicine (Berlin, Germany) (01.11.2011)
Published in Journal of molecular medicine (Berlin, Germany) (01.11.2011)
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Journal Article
Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo
Zachar, Zuzana, Marecek, James, Maturo, Claudia, Gupta, Sunita, Stuart, Shawn D., Howell, Katy, Schauble, Alexandra, Lem, Joanna, Piramzadian, Arin, Karnik, Sameer, Lee, King, Rodriguez, Robert, Shorr, Robert, Bingham, Paul M.
Published in Journal of molecular medicine (Berlin, Germany) (01.11.2011)
Published in Journal of molecular medicine (Berlin, Germany) (01.11.2011)
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Journal Article
Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy
Bingham, Paul M, Stuart, Shawn D, Zachar, Zuzana
Published in Expert review of clinical pharmacology (01.11.2014)
Published in Expert review of clinical pharmacology (01.11.2014)
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6,8-비스-벤질티오-옥탄산과 자가포식 억제제를 사용하는 암의 치료 방법 및 조성물
BINGHAM PAUL, ZACHAR ZUZANA, PARDEE TIMOTHY S, LUTHER SANJEEV, STUART SHAWN D, SHORR ROBERT G.L
Year of Publication 27.08.2021
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Year of Publication 27.08.2021
Patent
Abstract 2867: FDG-PET imaging as a potential biomarker of mitochondrial targeting by CPI-613, a novel inhibitor of mitochondrial metabolism
Sai, Kiran Solingapuram, Zachar, Zuzana, Almaguel, Frankis, Stuart, Shawn D., Dahan, Michael S., Guardado, Moises, Rideout, Stephanie, Wang, Minghui, Sattiraju, Anirudh, Bingham, Paul M., Pasche, Boris, Mintz, Akiva
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract A61: Tumor metabolic remodeling can modulate anticancer drug response: CPI-613 attack on tumor cell mitochondrial metabolism is mediated by metabolite availability
Stuart, Shawn D., Guardado, Moises, Dahan, Michael, Bingham, Paul M., Zachar, Zuzana
Published in Molecular cancer research (01.01.2016)
Published in Molecular cancer research (01.01.2016)
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Journal Article
Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613
Moises O Guardado Rivas, Shawn D Stuart, Daniel Thach, Michael Dahan, Robert Shorr, Zuzana Zachar, Paul M Bingham
Published in PloS one (01.01.2022)
Published in PloS one (01.01.2022)
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Journal Article
Abstract 1122: Lipoic acid analogs induce ROS, leading to potent mitochondrial enzyme inhibition, metabolic dysfunction and cell death in tumor cells
Stuart, Shawn D., Zachar, Zuzana, Gupta, Sunita, Rodriguez, Robert, Shorr, Robert, Bingham, Paul M.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING CANCER USING 6,8-BIS-BENZYLTHIO-OCTANOIC ACID AND AN AUTOPHAGY INHIBITOR
Bingham, Paul, Takeuchi, Tamotsu, Kito, Yusuke, Zachar, Zuzana, Stuart, Shawn D, Shorr, Robert G.L, Luther, Sanjeev, Saigo, Chiemi, Pardee, Timothy S
Year of Publication 24.02.2022
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Year of Publication 24.02.2022
Patent
THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING CANCER USING 6,8-BIS-BENZYLTHIO-OCTANOIC ACID AND AN AUTOPHAGY INHIBITOR
LUTHER Sanjeev, SHORR Robert G. L, KITO Yusuke, BINGHAM Paul, STUART Shawn D, PARDEE Timothy S, SAIGO Chiemi, TAKEUCHI Tamotsu, ZACHAR Zuzana
Year of Publication 30.09.2021
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Year of Publication 30.09.2021
Patent
THERAPEUTIC METHODS AND COMPOSITIONS FOR TREATING CANCER USING 6,8-BIS-BENZYLTHIO-OCTANOIC ACID AND AN AUTOPHAGY INHIBITOR
LUTHER, Sanjeev, STUART, Shawn D, KITO, Yusuke, TAKEUCHI, Tamotsu, SAIGO, Chiemi, SHORR, Robert G.L, PARDEE, Timothy S, ZACHAR, Zuzana, BINGHAM, Paul
Year of Publication 25.06.2020
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Year of Publication 25.06.2020
Patent