A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat
Lark, M.W, Stroup, G.B, James, I.E, Dodds, R.A, Hwang, S.M, Blake, S.M, Lechowska, B.A, Hoffman, S.J, Smith, B.R, Kapadia, R, Liang, X, Erhard, K, Ru, Y, Dong, X, Marquis, R.W, Veber, D, Gowen, M
Published in Bone (New York, N.Y.) (01.05.2002)
Published in Bone (New York, N.Y.) (01.05.2002)
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Plasma levels of parathyroid hormone that induce anabolic effects in bone of ovariectomized rats can be achieved by stimulation of endogenous hormone secretion
Fox, J., Miller, M.A., Stroup, G.B., Nemeth, E.F., Miller, S.C.
Published in Bone (New York, N.Y.) (01.08.1997)
Published in Bone (New York, N.Y.) (01.08.1997)
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Changes in bone turnover following gonadotropin-releasing hormone (GnRH) agonist administration and estrogen treatment in cynomolgus monkeys: a short-term model for evaluation of antiresorptive therapy
Stroup, G.B, Hoffman, S.J, Vasko-Moser, J.A, Lechowska, B.A, Jenkins, E.L, Dare, L.C, Gowen, M
Published in Bone (New York, N.Y.) (01.05.2001)
Published in Bone (New York, N.Y.) (01.05.2001)
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Leucocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in low-density lipoprotein receptor deficient mice
Guo, Jian, Bot, Ilze, de Nooijer, Ramon, Hoffman, Sandra J., Stroup, George B., Biessen, Erik A.L., Benson, G. Martin, Groot, Pieter H.E., Van Eck, Miranda, Van Berkel, Theo J.C.
Published in Cardiovascular research (01.02.2009)
Published in Cardiovascular research (01.02.2009)
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Journal Article
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats
Gowen, M, Stroup, G B, Dodds, R A, James, I E, Votta, B J, Smith, B R, Bhatnagar, P K, Lago, A M, Callahan, J F, DelMar, E G, Miller, M A, Nemeth, E F, Fox, J
Published in The Journal of clinical investigation (01.06.2000)
Published in The Journal of clinical investigation (01.06.2000)
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Journal Article
Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate
Stroup, George B., Lark, Michael W., Veber, Daniel F., Bhattacharyya, Amit, Blake, Simon, Dare, Lauren C., Erhard, Karl F., Hoffman, Sandra J., James, Ian E., Marquis, Robert W., Ru, Yu, Vasko‐Moser, Janice A., Smith, Brian R., Tomaszek, Thadeus, Gowen, Maxine
Published in Journal of bone and mineral research (01.10.2001)
Published in Journal of bone and mineral research (01.10.2001)
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Journal Article
Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice
Hankenson, K.D., James, I.E., Apone, S., Stroup, G.B., Blake, S.M., Liang, X., Lark, M.W., Bornstein, P.
Published in Matrix biology (01.08.2005)
Published in Matrix biology (01.08.2005)
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Response to continuous and pulsatile PTH dosing: A mathematical model for parathyroid hormone receptor kinetics
Potter, Laura K., Greller, Larry D., Cho, Carolyn R., Nuttall, Mark E., Stroup, George B., Suva, Larry J., Tobin, Frank L.
Published in Bone (New York, N.Y.) (01.08.2005)
Published in Bone (New York, N.Y.) (01.08.2005)
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Idoxifene: a novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats
Nuttall, M E, Bradbeer, J N, Stroup, G B, Nadeau, D P, Hoffman, S J, Zhao, H, Rehm, S, Gowen, M
Published in Endocrinology (Philadelphia) (01.12.1998)
Published in Endocrinology (Philadelphia) (01.12.1998)
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Disease‐modifying activity of SB 242235, a selective inhibitor of p38 mitogen‐activated protein kinase, in rat adjuvant‐induced arthritis
Badger, Alison M., Griswold, Don E., Kapadia, Rasesh, Blake, Simon, Swift, Barbara A., Hoffman, Sandy J., Stroup, George B., Webb, Edward, Rieman, David J., Gowen, Maxine, Boehm, Jeffrey C., Adams, Jerry L., Lee, John C.
Published in Arthritis and rheumatism (01.01.2000)
Published in Arthritis and rheumatism (01.01.2000)
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Antagonism of the Osteoclast Vitronectin Receptor with an Orally Active Nonpeptide Inhibitor Prevents Cancellous Bone Loss in the Ovariectomized Rat
Lark, Michael W., Stroup, George B., Dodds, Robert A., Kapadia, Rasesh, Hoffman, Sandra J., Hwang, Shing Mei, James, Ian E., Lechowska, Beata, Liang, Xiaoguang, Rieman, David J., Salyers, Kevin L., Ward, Keith, Smith, Brian R., Miller, William H., Huffman, William F., Gowen, Maxine
Published in Journal of bone and mineral research (01.02.2001)
Published in Journal of bone and mineral research (01.02.2001)
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Design and Characterization of Orally Active Arg-Gly-Asp Peptidomimetic Vitronectin Receptor Antagonist SB 265123 for Prevention of Bone Loss in Osteoporosis
Lark, M W, Stroup, G B, Hwang, S M, James, I E, Rieman, D J, Drake, F H, Bradbeer, J N, Mathur, A, Erhard, K F, Newlander, K A, Ross, S T, Salyers, K L, Smith, B R, Miller, W H, Huffman, W F, Gowen, M
Published in The Journal of pharmacology and experimental therapeutics (01.11.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.11.1999)
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Idoxifene, a Novel Selective Estrogen Receptor Modulator, Is Effective in a Rat Model of Adjuvant-Induced Arthritis
Badger, A M, Blake, S M, Dodds, R A, Griswold, D E, Swift, B A, Rieman, D J, Stroup, G B, Hoffman, S J, Gowen, M
Published in The Journal of pharmacology and experimental therapeutics (01.12.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1999)
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Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells
Nuttall, Mark E, Stroup, George B, Fisher, Paul W, Nadeau, Daniel P, Gowen, Maxine, Suva, Larry J
Published in American Journal of Physiology: Cell Physiology (01.11.2000)
Published in American Journal of Physiology: Cell Physiology (01.11.2000)
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Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells
Rickard, David J., Wang, Fei-Lan, Rodriguez-Rojas, Ana-Maria, Wu, Zining, Trice, Wen J., Hoffman, Sandra J., Votta, Bartholomew, Stroup, George B., Kumar, Sanjay, Nuttall, Mark E.
Published in Bone (New York, N.Y.) (01.12.2006)
Published in Bone (New York, N.Y.) (01.12.2006)
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An Azepanone-Based Inhibitor of Human Cathepsin K with Improved Oral Bioavailability in the Rat and the Monkey
Marquis, Robert W, Ward, Keith W, Roethke, Theresa, Smith, Brian R, Ru, Yu, Yamashita, Dennis S, Tomaszek, Thaddeus A, Gorycki, Peter D, Cheng, H.-Y, James, Ian E, Stroup, George B, Lark, Michael W, Gowen, Maxine, Veber, Daniel F
Published in Molecular pharmaceutics (12.01.2004)
Published in Molecular pharmaceutics (12.01.2004)
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