Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
Spilman, Patricia, Podlutskaya, Natalia, Hart, Matthew J, Debnath, Jayanta, Gorostiza, Olivia, Bredesen, Dale, Richardson, Arlan, Strong, Randy, Galvan, Veronica
Published in PloS one (01.04.2010)
Published in PloS one (01.04.2010)
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Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
Miller, Richard A., Harrison, David E., Astle, Clinton M., Fernandez, Elizabeth, Flurkey, Kevin, Han, Melissa, Javors, Martin A., Li, Xinna, Nadon, Nancy L., Nelson, James F., Pletcher, Scott, Salmon, Adam B., Sharp, Zelton Dave, Van Roekel, Sabrina, Winkleman, Lynn, Strong, Randy
Published in Aging cell (01.06.2014)
Published in Aging cell (01.06.2014)
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Journal Article
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Nelson, James F, Carter, Christy S, Pahor, Marco, Frenkel, Krystyna, Miller, Richard A, Nadon, Nancy L, Wilkinson, J. Erby, Fernandez, Elizabeth, Javors, Martin A, Flurkey, Kevin, Astle, Clinton M, Sharp, Zelton Dave, Harrison, David E, Strong, Randy
Published in Nature (London) (16.07.2009)
Published in Nature (London) (16.07.2009)
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Journal Article
Rapamycin slows aging in mice
Wilkinson, John E., Burmeister, Lisa, Brooks, Susan V., Chan, Chi‐Chao, Friedline, Sabrina, Harrison, David E., Hejtmancik, James F., Nadon, Nancy, Strong, Randy, Wood, Lauren K., Woodward, Maria A., Miller, Richard A.
Published in Aging cell (01.08.2012)
Published in Aging cell (01.08.2012)
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Journal Article
Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease
Goldstein, David S., Sullivan, Patti, Holmes, Courtney, Miller, Gary W., Alter, Shawn, Strong, Randy, Mash, Deborah C., Kopin, Irwin J., Sharabi, Yehonatan
Published in Journal of neurochemistry (01.09.2013)
Published in Journal of neurochemistry (01.09.2013)
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Journal Article
Late‐life rapamycin treatment reverses age‐related heart dysfunction
Flynn, James M., O'Leary, Monique N., Zambataro, Christopher A., Academia, Emmeline C., Presley, Michael P., Garrett, Brittany J., Zykovich, Artem, Mooney, Sean D., Strong, Randy, Rosen, Clifford J., Kapahi, Pankaj, Nelson, Michael D., Kennedy, Brian K., Melov, Simon
Published in Aging cell (01.10.2013)
Published in Aging cell (01.10.2013)
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Journal Article
Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson’s diseases
Song, Chengjie, Zhang, Jun, Qi, Shasha, Liu, Zhen, Zhang, Xiaoyang, Zheng, Yue, Andersen, John‐Paul, Zhang, Weiping, Strong, Randy, Martinez, Paul Anthony, Musi, Nicolas, Nie, Jia, Shi, Yuguang
Published in Aging cell (01.06.2019)
Published in Aging cell (01.06.2019)
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Journal Article
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival
Ramos, Fresnida J, Chen, Steven C, Garelick, Michael G, Dai, Dao-Fu, Liao, Chen-Yu, Schreiber, Katherine H, MacKay, Vivian L, An, Elroy H, Strong, Randy, Ladiges, Warren C, Rabinovitch, Peter S, Kaeberlein, Matt, Kennedy, Brian K
Published in Science translational medicine (25.07.2012)
Published in Science translational medicine (25.07.2012)
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Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice
Poudel, Sher Bahadur, Ruff, Ryan R, Yildirim, Gozde, Miller, Richard A, Harrison, David E, Strong, Randy, Kirsch, Thorsten, Yakar, Shoshana
Published in Arthritis research & therapy (08.06.2024)
Published in Arthritis research & therapy (08.06.2024)
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Journal Article
Glycine supplementation extends lifespan of male and female mice
Miller, Richard A., Harrison, David E., Astle, C. Michael, Bogue, Molly A., Brind, Joel, Fernandez, Elizabeth, Flurkey, Kevin, Javors, Martin, Ladiges, Warren, Leeuwenburgh, Christiaan, Macchiarini, Francesca, Nelson, James, Ryazanov, Alexey G., Snyder, Jessica, Stearns, Timothy M., Vaughan, Douglas E., Strong, Randy
Published in Aging cell (01.06.2019)
Published in Aging cell (01.06.2019)
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Journal Article
Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease
Wey, Margaret Chia-Ying, Fernandez, Elizabeth, Martinez, Paul Anthony, Sullivan, Patricia, Goldstein, David S, Strong, Randy
Published in PloS one (22.02.2012)
Published in PloS one (22.02.2012)
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Journal Article
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
Price, David A., Martinez, Alex A., Seillier, Alexandre, Koek, Wouter, Acosta, Yolanda, Fernandez, Elizabeth, Strong, Randy, Lutz, Beat, Marsicano, Giovanni, Roberts, James L., Giuffrida, Andrea
Published in The European journal of neuroscience (01.06.2009)
Published in The European journal of neuroscience (01.06.2009)
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Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice
Guderyon, Michael J., Chen, Cang, Bhattacharjee, Anindita, Ge, Guo, Fernandez, Roman A., Gelfond, Jonathan A. L., Gorena, Karla M., Cheng, Catherine J., Li, Yang, Nelson, James F., Strong, Randy J., Hornsby, Peter J., Clark, Robert A., Li, Senlin
Published in Aging cell (01.03.2020)
Published in Aging cell (01.03.2020)
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Journal Article
Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease
Li, Xiuhua, Redus, Laney, Chen, Cang, Martinez, Paul A, Strong, Randy, Li, Senlin, O'Connor, Jason C
Published in PloS one (15.08.2013)
Published in PloS one (15.08.2013)
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Journal Article
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
Strong, Randy , Miller, Richard A. , Astle, Clinton M. , Floyd, Robert A. , Flurkey, Kevin , Hensley, Kenneth L. , Javors, Martin A. , Leeuwenburgh, Christiaan , Nelson, James F. , Ongini, Ennio , Nadon, Nancy L. , Warner, Huber R. , Harrison, David E.
Published in Aging cell (01.10.2008)
Published in Aging cell (01.10.2008)
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Journal Article
Canagliflozin extends life span in genetically heterogeneous male but not female mice
Miller, Richard A, Harrison, David E, Allison, David B, Bogue, Molly, Debarba, Lucas, Diaz, Vivian, Fernandez, Elizabeth, Galecki, Andrzej, Garvey, W Timothy, Jayarathne, Hashan, Kumar, Navasuja, Javors, Martin A, Ladiges, Warren C, Macchiarini, Francesca, Nelson, James, Reifsnyder, Peter, Rosenthal, Nadia A, Sadagurski, Marianna, Salmon, Adam B, Smith, Jr, Daniel L, Snyder, Jessica M, Lombard, David B, Strong, Randy
Published in JCI insight (05.11.2020)
Published in JCI insight (05.11.2020)
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Journal Article
Probing the relationship between insulin sensitivity and longevity using genetically modified mice
Nelson, James F, Strong, Randy, Bokov, Alex, Diaz, Vivian, Ward, Walter
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.12.2012)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.12.2012)
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