Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains
Swanger, Sharon A., Chen, Wenjuan, Wells, Gordon, Burger, Pieter B., Tankovic, Anel, Bhattacharya, Subhrajit, Strong, Katie L., Hu, Chun, Kusumoto, Hirofumi, Zhang, Jing, Adams, David R., Millichap, John J., Petrovski, Slavé, Traynelis, Stephen F., Yuan, Hongjie
Published in American journal of human genetics (01.12.2016)
Published in American journal of human genetics (01.12.2016)
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GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity
Perszyk, Riley E, DiRaddo, John O, Strong, Katie L, Low, Chian-Ming, Ogden, Kevin K, Khatri, Alpa, Vargish, Geoffrey A, Pelkey, Kenneth A, Tricoire, Ludovic, Liotta, Dennis C, Smith, Yoland, McBain, Chris J, Traynelis, Stephen F
Published in Molecular pharmacology (01.12.2016)
Published in Molecular pharmacology (01.12.2016)
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Discovery of Dihydropyrrolo[1,2‑a]pyrazin-3(4H)‑one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N‑Methyl‑d‑Aspartate (NMDA) Receptor
Epplin, Matthew P, Mohan, Ayush, Harris, Lynnea D, Zhu, Zongjian, Strong, Katie L, Bacsa, John, Le, Phuong, Menaldino, David S, Traynelis, Stephen F, Liotta, Dennis C
Published in Journal of medicinal chemistry (23.07.2020)
Published in Journal of medicinal chemistry (23.07.2020)
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The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor
Kaiser, Thomas M, Kell, Steven A, Kusumoto, Hirofumi, Shaulsky, Gil, Bhattacharya, Subhrajit, Epplin, Matthew P, Strong, Katie L, Miller, Eric J, Cox, Bryan D, Menaldino, David S, Liotta, Dennis C, Traynelis, Stephen F, Burger, Pieter B
Published in Molecular pharmacology (01.02.2018)
Published in Molecular pharmacology (01.02.2018)
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The Structure–Activity Relationship of a Tetrahydroisoquinoline Class of N‑Methyl‑d‑Aspartate Receptor Modulators that Potentiates GluN2B-Containing N‑Methyl‑d‑Aspartate Receptors
Strong, Katie L, Epplin, Matthew P, Bacsa, John, Butch, Christopher J, Burger, Pieter B, Menaldino, David S, Traynelis, Stephen F, Liotta, Dennis C
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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NMDA receptor modulators: an updated patent review (2013-2014)
Strong, Katie L, Jing, Yao, Prosser, Anthony R, Traynelis, Stephen F, Liotta, Dennis C
Published in Expert opinion on therapeutic patents (01.12.2014)
Published in Expert opinion on therapeutic patents (01.12.2014)
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Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N‑Methyl‑d‑aspartate Receptors
Santangelo Freel, Rose M, Ogden, Kevin K, Strong, Katie L, Khatri, Alpa, Chepiga, Kathryn M, Jensen, Henrik S, Traynelis, Stephen F, Liotta, Dennis C
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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Journal Article
Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N -Methyl-d-aspartate Receptors
Strong, Katie L, Epplin, Matthew P, Ogden, Kevin K, Burger, Pieter B, Kaiser, Thomas M, Wilding, Timothy J, Kusumoto, Hiro, Camp, Chad R, Shaulsky, Gil, Bhattacharya, Subhrajit, Perszyk, Riley E, Menaldino, David S, McDaniel, Miranda J, Zhang, Jing, Le, Phuong, Banke, Tue G, Hansen, Kasper B, Huettner, James E, Liotta, Dennis C, Traynelis, Stephen F
Published in ACS chemical neuroscience (06.01.2021)
Published in ACS chemical neuroscience (06.01.2021)
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Journal Article
Novel NMDA receptor modulators: an update
Santangelo, Rose M, Acker, Timothy M, Zimmerman, Sommer S, Katzman, Brooke M, Strong, Katie L, Traynelis, Stephen F, Liotta, Dennis C
Published in Expert opinion on therapeutic patents (01.11.2012)
Published in Expert opinion on therapeutic patents (01.11.2012)
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Journal Article
Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N‑Methyl‑d‑aspartate Receptors
Santangelo Freel, Rose M, Ogden, Kevin K, Strong, Katie L, Khatri, Alpa, Chepiga, Kathryn M, Jensen, Henrik S, Traynelis, Stephen F, Liotta, Dennis C
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Journal Article
The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-D-Aspartate Receptor Modulators that Potentiates GIuN2B-Containing N-Methyl-D-Aspartate Receptors
Strong, Katie L., Epplin, Matthew P., Bacsa, John, Butch, Christopher J., Burger, Pieter B., Menaldino, David S., Traynelis, Stephen F., Liotta, Dennis C.
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Journal Article
Channel Open Probability Controls Allosteric Modulation of Potency and Efficacy
Perszyk, Riley E., Ogden, Kevin K., Strong, Katie L., Liotta, Dennis C., Traynelis, Stephen F.
Published in Biophysical journal (03.02.2017)
Published in Biophysical journal (03.02.2017)
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