Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
Huber, Kilian V. M., Salah, Eidarus, Radic, Branka, Gridling, Manuela, Elkins, Jonathan M., Stukalov, Alexey, Jemth, Ann-Sofie, Göktürk, Camilla, Sanjiv, Kumar, Strömberg, Kia, Pham, Therese, Berglund, Ulrika Warpman, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna I., Helleday, Thomas, Knapp, Stefan, Superti-Furga, Giulio
Published in Nature (London) (10.04.2014)
Published in Nature (London) (10.04.2014)
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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Published in Nature communications (2018)
Published in Nature communications (2018)
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New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain
Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain
Lund, Harald, Cowburn, Richard F., Gustafsson, Elin, Strömberg, Kia, Svensson, Anne, Dahllund, Leif, Malinowsky, David, Sunnemark, Dan
Published in Brain pathology (Zurich, Switzerland) (01.07.2013)
Published in Brain pathology (Zurich, Switzerland) (01.07.2013)
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Combining an amyloid‐beta (Aβ) cleaving enzyme inhibitor with a γ‐secretase modulator results in an additive reduction of Aβ production
Strömberg, Kia, Eketjäll, Susanna, Georgievska, Biljana, Tunblad, Karin, Eliason, Kristina, Olsson, Fredrik, Radesäter, Ann‐Cathrin, Klintenberg, Rebecka, Arvidsson, Per I, Berg, Stefan, Fälting, Johanna, Cowburn, Richard F, Dabrowski, Michael
Published in The FEBS journal (2015)
Published in The FEBS journal (2015)
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Imatinib treatment and Aβ42 in humans
Olsson, Bob, Legros, Laurence, Guilhot, François, Strömberg, Kia, Smith, James, Livesey, Frederick J, Wilson, David H, Zetterberg, Henrik, Blennow, Kaj
Published in Alzheimer's & dementia (01.10.2014)
Published in Alzheimer's & dementia (01.10.2014)
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Second Generation γ-Secretase Modulators Exhibit Different Modulation of Notch β and Aβ Production
Wanngren, Johanna, Ottervald, Jan, Parpal, Santiago, Portelius, Erik, Strömberg, Kia, Borgegård, Tomas, Klintenberg, Rebecka, Juréus, Anders, Blomqvist, Jenny, Blennow, Kaj, Zetterberg, Henrik, Lundkvist, Johan, Rosqvist, Susanne, Karlström, Helena
Published in The Journal of biological chemistry (21.09.2012)
Published in The Journal of biological chemistry (21.09.2012)
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Triazolopyrimidinones as γ-secretase modulators: structure–activity relationship, modulator profile, and in vivo profiling
Yngve, Ulrika, Paulsen, Kim, Macsari, Istvan, Sundström, Marie, Santangelo, Ellen, Linde, Christian, Bogar, Krisztian, Lake, Fredrik, Besidski, Yevgeni, Malmborg, Jonas, Strömberg, Kia, Appelkvist, Paulina, Radesäter, Ann-Cathrine, Olsson, Fredrik, Bergström, Daniel, Klintenberg, Rebecka, Arvidsson, Per I.
Published in MedChemComm (2013)
Published in MedChemComm (2013)
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Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Published in Nature communications (01.11.2019)
Published in Nature communications (01.11.2019)
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Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
Zhang, Si Min, Paulin, Cynthia B.J., Shu, Huazhang, Yagüe-Capilla, Miriam, Michel, Maurice, Marttila, Petra, Ortis, Florian, Bwanika, Henri Colyn, Dirks, Christopher, Venkatram, Rajagopal Papagudi, Wiita, Elisée, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Hormann, Femke M., Koolmeister, Tobias, Linde, Erika, Lee, Sun, Llona-Minguez, Sabin, Haraldsson, Martin, Axelsson, Hanna, Strömberg, Kia, Homan, Evert J., Scobie, Martin, Lundbäck, Thomas, Helleday, Thomas, Rudd, Sean G.
Published in iScience (16.02.2024)
Published in iScience (16.02.2024)
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Journal Article
Correction to New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain
Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Bogar, Krisztian, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms
Borgegard, Tomas, Juréus, Anders, Olsson, Fredrik, Rosqvist, Susanne, Sabirsh, Alan, Rotticci, Didier, Paulsen, Kim, Klintenberg, Rebecka, Yan, Hongmei, Waldman, Magnus, Stromberg, Kia, Nord, Johan, Johansson, Jonas, Regner, Anna, Parpal, Santiago, Malinowsky, David, Radesater, Ann-Cathrin, Li, Tingsheng, Singh, Rajeshwar, Eriksson, Hakan, Lundkvist, Johan
Published in The Journal of biological chemistry (06.04.2012)
Published in The Journal of biological chemistry (06.04.2012)
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Journal Article
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (vol 9, 250, 2018)
Page, BDG, Valerie, NCK, Wright, RHG, Wallner, O, Isaksson, R, Carter, M, Rudd, SG, Loseva, O, Jemth, A-S, Almlof, I
Published in NATURE COMMUNICATIONS (01.11.2019)
Published in NATURE COMMUNICATIONS (01.11.2019)
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Publication
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (vol 508, pg 215, 2014)
Gad, H, Koolmeister, T, Jemth, A-S, Eshtad, S, Jacques, SA, Strom, CE, Svensson, LM, Schultz, N, Lundback, T, Einarsdottir, BO
Published in NATURE (27.04.2017)
Published in NATURE (27.04.2017)
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Publication
Combining an amyloid-beta (A[beta]) cleaving enzyme inhibitor with a [gamma]-secretase modulator results in an additive reduction of A[beta] production
Stromberg, Kia, Eketjall, Susanna, Georgievska, Biljana, Tunblad, Karin, Eliason, Kristina, Olsson, Fredrik, Radesater, Ann-Cathrin, Klintenberg, Rebecka, Arvidsson, Per I, Berg, Stefan, Falting, Johanna, Cowburn, Richard F, Dabrowski, Michael
Published in The FEBS journal (01.01.2015)
Published in The FEBS journal (01.01.2015)
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Journal Article
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad, Helge, Koolmeister, Tobias, Jemth, Ann-Sofie, Eshtad, Saeed, Jacques, Sylvain A., Ström, Cecilia E., Svensson, Linda M., Schultz, Niklas, Lundbäck, Thomas, Einarsdottir, Berglind Osk, Saleh, Aljona, Göktürk, Camilla, Baranczewski, Pawel, Svensson, Richard, Berntsson, Ronnie P.-A., Gustafsson, Robert, Strömberg, Kia, Sanjiv, Kumar, Jacques-Cordonnier, Marie-Caroline, Desroses, Matthieu, Gustavsson, Anna-Lena, Olofsson, Roger, Johansson, Fredrik, Homan, Evert J., Loseva, Olga, Bräutigam, Lars, Johansson, Lars, Höglund, Andreas, Hagenkort, Anna, Pham, Therese, Altun, Mikael, Gaugaz, Fabienne Z., Vikingsson, Svante, Evers, Bastiaan, Henriksson, Martin, Vallin, Karl S. A., Wallner, Olov A., Hammarström, Lars G. J., Wiita, Elisee, Almlöf, Ingrid, Kalderén, Christina, Axelsson, Hanna, Djureinovic, Tatjana, Puigvert, Jordi Carreras, Häggblad, Maria, Jeppsson, Fredrik, Martens, Ulf, Lundin, Cecilia, Lundgren, Bo, Granelli, Ingrid, Jensen, Annika Jenmalm, Artursson, Per, Nilsson, Jonas A., Stenmark, Pål, Scobie, Martin, Berglund, Ulrika Warpman, Helleday, Thomas
Published in Nature (London) (10.04.2014)
Published in Nature (London) (10.04.2014)
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Journal Article
Tau‐Tubulin Kinase 1 Expression, Phosphorylation and Co‐Localization with Phospho‐ S er422 Tau in the A lzheimer's Disease Brain
Lund, Harald, Cowburn, Richard F., Gustafsson, Elin, Strömberg, Kia, Svensson, Anne, Dahllund, Leif, Malinowsky, David, Sunnemark, Dan
Published in Brain pathology (Zurich, Switzerland) (01.07.2013)
Published in Brain pathology (Zurich, Switzerland) (01.07.2013)
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Journal Article
Correction: Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad, Helge, Koolmeister, Tobias, Jemth, Ann-Sofie, Eshtad, Saeed, Jacques, Sylvain A., Ström, Cecilia E., Svensson, Linda M., Schultz, Niklas, Lundbäck, Thomas, Einarsdottir, Berglind Osk, Saleh, Aljona, Göktürk, Camilla, Baranczewski, Pawel, Svensson, Richard, Berntsson, Ronnie P.-A., Gustafsson, Robert, Strömberg, Kia, Sanjiv, Kumar, Jacques-Cordonnier, Marie-Caroline, Desroses, Matthieu, Gustavsson, Anna-Lena, Olofsson, Roger, Johansson, Fredrik, Homan, Evert J., Loseva, Olga, Bräutigam, Lars, Johansson, Lars, Höglund, Andreas, Hagenkort, Anna, Pham, Therese, Altun, Mikael, Gaugaz, Fabienne Z., Vikingsson, Svante, Evers, Bastiaan, Henriksson, Martin, Vallin, Karl S. A., Wallner, Olov A., Hammarström, Lars G. J., Wiita, Elisee, Almlöf, Ingrid, Kalderén, Christina, Axelsson, Hanna, Djureinovic, Tatjana, Carreras Puigvert, Jordi, Häggblad, Maria, Jeppsson, Fredrik, Martens, Ulf, Lundin, Cecilia, Lundgren, Bo, Granelli, Ingrid, Jenmalm Jensen, Annika, Artursson, Per, Nilsson, Jonas A., Stenmark, Pål, Scobie, Martin
Published in Nature (London) (27.04.2017)
Published in Nature (London) (27.04.2017)
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Journal Article
P2‐317: Impact of different γ‐secretase modulators on Notch‐1 Abeta‐like peptide (Nβ) formation
Wanngren, Johanna, Ottervald, Jan, Parpal, Santiago, Olsson, Fredrik, Strömberg, Kia, Blomqvist, Jenny, Wollberg, Patrik, Malinowsky, David, Winblad, Bengt, Lundkvist, Johan, Rosqvist, Susanne, Karlström, Helena
Published in Alzheimer's & dementia (01.07.2011)
Published in Alzheimer's & dementia (01.07.2011)
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