Heterodimeric IL-15 in Cancer Immunotherapy
Bergamaschi, Cristina, Stravokefalou, Vasiliki, Stellas, Dimitris, Karaliota, Sevasti, Felber, Barbara K, Pavlakis, George N
Published in Cancers (17.02.2021)
Published in Cancers (17.02.2021)
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Journal Article
Heterodimeric IL-15 (hetIL-15) reduces circulating tumor cells and metastasis formation improving chemotherapy and surgery in 4T1 mouse model of TNBC
Stravokefalou, Vasiliki, Stellas, Dimitris, Karaliota, Sevasti, Nagy, Bethany A, Valentin, Antonio, Bergamaschi, Cristina, Dimas, Konstantinos, Pavlakis, George N
Published in Frontiers in immunology (13.01.2023)
Published in Frontiers in immunology (13.01.2023)
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Journal Article
Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population
Stellas, Dimitris, Karaliota, Sevasti, Stravokefalou, Vasiliki, Angel, Matthew, Nagy, Bethany A., Goldfarbmuren, Katherine C., Bergamaschi, Cristina, Felber, Barbara K., Pavlakis, George N.
Published in Cell reports (Cambridge) (30.05.2023)
Published in Cell reports (Cambridge) (30.05.2023)
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Journal Article
A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer
Mourkioti, Ioanna, Polyzou, Aikaterini, Veroutis, Dimitris, Theocharous, George, Lagopati, Nefeli, Gentile, Emanuela, Stravokefalou, Vasiliki, Thanos, Dimitris-Foivos, Havaki, Sophia, Kletsas, Dimitris, Panaretakis, Theocharis, Logothetis, Christopher J, Stellas, Dimitris, Petty, Russell, Blandino, Giovanni, Papaspyropoulos, Angelos, Gorgoulis, Vassilis G
Published in Journal of experimental & clinical cancer research (29.07.2023)
Published in Journal of experimental & clinical cancer research (29.07.2023)
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575 Regression by hetIL-15 monotherapy in different mouse breast cancer models correlates with intratumoral infiltration of a novel population of dendritic cells
Karaliota, Sevasti, Stellas, Dimitris, Stravokefalou, Vasiliki, Nagy, Bethany, Bergamaschi, Cristina, Felber, Barbara, Pavlakis, George
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Synergy of heterodimeric IL-15 immunotherapy and a Fatty Acid Metabolism Modulator enhances intratumoral lymphocyte metabolism and eradicates EO771 murine breast tumors
KARALIOTA, SEVASTI, Stellas, Dimitris, Stravokefalou, Vasiliki, Myers, Breana, Felber, Barbara K., Pavlakis, George N
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Abstract 5694: Complete regression of murine breast tumors by hetIL-15FC monotherapy correlates with infiltration by T, NK, cDC1 cells and a novel population of dendritic cells
Karaliota, Sevasti, Stellas, Dimitris, Stravokefalou, Vasiliki, Nagy, Bethany, Bergamaschi, Cristina, Felber, Barbara K., Pavlakis, George N.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Regression of murine breast tumors after hetIL-15 monotherapy correlates with a novel population of intratumoral dendritic cells, in addition to increased infiltration of T, NK and cDC1 cells
Pavlakis, George N, Karaliota, Sevasti, Stellas, Dimitri, Bergamaschi, Cristina, Stravokefalou, Vasiliki, Nagy, Bethany, Felber, Barbara K.
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
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Journal Article
Abstract 2727: Heterodimeric IL-15 (hetIL-15) affects conventional dendritic cells and a distinct novel dendritic cell population in different mouse cancer models of breast and pancreatic cancer
Stravokefalou, Vasiliki, Stellas, Dimitris, Karaliota, Sevasti, Nagy, Bethany, Guerin, Theresa, Kozlov, Serguei, Felber, Barbara K., Pavlakis, George N.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 3259: heterodimeric IL-15 monotherapy results in complete regression of EO771 murine breast tumors through cDC1-lymphocyte interactions and induction of antitumor immunity
Stellas, Dimitris, Karaliota, Sevasti, Stravokefalou, Vasiliki, Nagy, Bethany A., Felber, Barbara K., Pavlakis, George N.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 6651: Combination of hetIL-15 with chemotherapy in triple negative breast and pancreatic cancer mouse models increases tumor necrosis and alleviates metastatic disease
Stellas, Dimitris, Stravokefalou, Vasiliki, Karaliota, Sevasti, Nagy, Bethany, Koslov, Serguei, Dimas, Konstantinos, Felber, Barbara K., Pavlakis, George N.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Mechanism of Heterodimeric IL-15 in tumor reduction: Induction of myeloid-lymphoid cell interactions leads to IFN-γ dependent lymphocyte recruitment by dendritic cells into tumors
Pavlakis, George N, Bergamaschi, Cristina, Stellas, Dimitri, Karaliota, Sevasti, Nagy, Bethany, Stravokefalou, Vasiliki, Dimas, Konstantinos, Jensen, Shawn, Fox, Bernard A., Felber, Barbara K.
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
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Journal Article
Abstract 5082: Heterodimeric IL-15 (hetIL-15) immunotherapy synergizes with Fatty Acid Metabolism Modulator (FAMM) to eradicate TNBC EO771 murine tumors
Karaliota, Sevasti, Stellas, Dimitris, Stravokefalou, Vasiliki, Myers, Breana, Felber, Barbara K., Pavlakis, George N.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 4064: hetIL-15 and Fenofibrate combination alters the metabolic fitness of tumor-infiltrating CD8+T cells leading to TNBC tumor eradication in mice
Stellas, Dimitris, Karaliota, Sevasti, Stravokefalou, Vasiliki, Goldfarbmuren, Katherine C., Myers, Breana, Pavlakis, George N., Felber, Barbara K.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 5603: Heterodimeric IL-15 (hetIL-15) immunotherapy reverses CD8+T cell metabolic dysfunction in murine breast tumors
Stellas, Dimitris, Karaliota, Sevasti, Stravokefalou, Vasiliki, Myers, Breana, Felber, Barbara K., Pavlakis, George N.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 2441: hetIL-15 decreases tumor cell dissemination and colonization and synergizes with chemotherapy and surgery to cure murine 4T1 breast tumors
Stravokefalou, Vasiliki, Stellas, Dimitris, Karaliota, Sevasti, Myers, Breana, Bergamaschi, Cristina, Dimas, Konstantinos, Felber, Barbara K., Pavlakis, George N.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103 int CD11b + dendritic cell population
Stellas, Dimitris, Karaliota, Sevasti, Stravokefalou, Vasiliki, Angel, Matthew, Nagy, Bethany A, Goldfarbmuren, Katherine C, Bergamaschi, Cristina, Felber, Barbara K, Pavlakis, George N
Published in Cell reports (Cambridge) (30.05.2023)
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Published in Cell reports (Cambridge) (30.05.2023)
Journal Article