Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position
Tucker, Thomas J, Brady, Stephen F, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Naylor-Olsen, Adel M, Yan, Youwei, Sisko, Jack T, Stauffer, Kenneth J, Lucas, Bobby J, Lynch, Joseph J, Cook, Jacquelynn J, Stranieri, Maria T, Holahan, Marie A, Lyle, Elizabeth A, Baskin, Elizabeth P, Chen, I-Wu, Dancheck, Kimberly B, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P
Published in Journal of medicinal chemistry (13.08.1998)
Published in Journal of medicinal chemistry (13.08.1998)
Get full text
Journal Article
Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates
Sanderson, Philip E. J, Lyle, Terry A, Cutrona, Kellie J, Dyer, Dona L, Dorsey, Bruce D, McDonough, Colleen M, Naylor-Olsen, Adel M, Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J, Cooper, Carolyn M, Gardell, Stephen J, Hare, Timothy R, Krueger, Julie A, Lewis, S. Dale, Lin, Jiunn H, Lucas, Bobby J, Lyle, Elizabeth A, Lynch, Joseph J, Stranieri, Maria T, Vastag, Kari, Yan, Youwei, Shafer, Jules A, Vacca, Joseph P
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
Get full text
Journal Article
Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460): Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support
Brady, Stephen F, Stauffer, Kenneth J, Lumma, William C, Smith, Graham M, Ramjit, Harri G, Lewis, S. Dale, Lucas, Bobby J, Gardell, Steven J, Lyle, Elizabeth A, Appleby, Sandra D, Cook, Jacquelynn J, Holahan, Marie A, Stranieri, Maria T, Lynch, Joseph J, Lin, Jiunn H, Chen, I.-Wu, Vastag, Kari, Naylor-Olsen, Adel M, Vacca, Joseph P
Published in Journal of medicinal chemistry (29.01.1998)
Published in Journal of medicinal chemistry (29.01.1998)
Get full text
Journal Article
Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation
Egbertson, Melissa S, Cook, Jacquelynn J, Bednar, Bohumil, Prugh, John D, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Hartman, George D, Homnick, Carl F, Holahan, Marie A, Libby, Laura A, Lynch, Joseph J, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Vassallo, Laura M
Published in Journal of medicinal chemistry (01.07.1999)
Published in Journal of medicinal chemistry (01.07.1999)
Get full text
Journal Article
Nonpeptide glycoprotein IIb/IIIa inhibitors. 5. Antithrombotic effects of MK-0383
J J Lynch, Jr, J J Cook, G R Sitko, M A Holahan, D R Ramjit, M J Mellott, M T Stranieri, I I Stabilito, G Zhang, R J Lynch
Published in The Journal of pharmacology and experimental therapeutics (01.01.1995)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.01.1995)
Journal Article
L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor
Sanderson, Philip E.J., Cutrona, Kellie J., Dorsey, Bruce D., Dyer, Dona L., McDonough, Colleen M., Naylor-Olsen, Adel M., Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J., Gardell, Stephen J., Krueger, Julie A., Lewis, S.Dale, Lin, Jiunn H., Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Stranieri, Maria T., Vastag, Kari, Shafer, Jules A., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
Get full text
Journal Article
Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists
Askew, Benny C, Bednar, Rodney A, Bednar, Bohumil, Claremon, David A, Cook, Jacquelynn J, McIntyre, Charles J, Hunt, Cecila A, Gould, Robert J, Lynch, Robert J, Lynch, Joseph J, Gaul, Stanley L, Stranieri, Maria T, Sitko, Gary R, Holahan, Marie A, Glass, Joan D, Hamill, Terrence, Gorham, Lynn M, Prueksaritanont, Thomayant, Baldwin, John J, Hartman, George D
Published in Journal of medicinal chemistry (06.06.1997)
Published in Journal of medicinal chemistry (06.06.1997)
Get full text
Journal Article
Antithrombotic effects of MK-0852, a platelet fibrinogen receptor antagonist, in canine models of thrombosis
D R Ramjit, J J Lynch, Jr, G R Sitko, M J Mellott, M A Holahan, I I Stabilito, M T Stranieri, G Zhang, R J Lynch, P D Manno
Published in The Journal of pharmacology and experimental therapeutics (01.09.1993)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.09.1993)
Journal Article
C6 Modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption
Isaacs, Richard C.A., Cutrona, Kellie J., Newton, Christina L., Sanderson, Philip E.J., Solinsky, Mark G., Baskin, Elizabeth P., Chen, I-Wu, Cooper, Carolyn M., Cook, Jacquelynn J., Gardell, Stephen J., Lewis, S.Dale, Lucas, Robert J., Lyle, Elizabeth A., Lynch, Joseph J., Naylor-Olsen, Adel M., Stranieri, Maria T., Vastag, Kari, Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
Get full text
Journal Article
Investigation of (Oxodioxolenyl)methyl Carbamates as Nonchiral Bioreversible Prodrug Moieties for Chiral Amines
Alexander, Jose, Bindra, Dilbir S, Glass, Joan D, Holahan, Marie A, Renyer, Mara L, Rork, Gerald S, Sitko, Gary R, Stranieri, Maria T, Stupienski, Raymond F, Veerapanane, Hemalata, Cook, Jacquelynn J
Published in Journal of medicinal chemistry (19.01.1996)
Published in Journal of medicinal chemistry (19.01.1996)
Get full text
Journal Article
Nonpeptide glycoprotein IIb/IIIa inhibitors. 13. design and synthesis of an orally active pyrazolopiperazinone nonpeptide fibrinogen receptor antagonist
Askew, B.C., McIntyre, C.J., Hunt, C.A., Claremon, D.A., Baldwin, J.J., Anderson, P.S., Gould, R.J., Lynch, R.J., Chang, C.C-T., Cook, J.J., Lynch, J.J., Holahan, M.A., Sitko, G.R., Stranieri, M.T.
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
Get full text
Journal Article
Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217
J J Cook, M A Holahan, E A Lyle, D R Ramjit, G R Sitko, M T Stranieri, R F Stupienski, 3rd, A A Wallace, E L Hand, J R Gehret, T Kothstein, M D Drag, G Y McCormick, J J Perkins, N C Ihle, M E Duggan, G D Hartman, R J Gould, J J Lynch, Jr
Published in The Journal of pharmacology and experimental therapeutics (01.07.1996)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.07.1996)
Journal Article
Effects of pentobarbital on pharmacokinetics and pharmacodynamics of a potent fibrinogen receptor antagonist, L-734 217, in dogs
Prueksaritanont, T., Stranieri, M. T., Hand, E. L., Ellis, J. D., Holahan, M. A., Sitko, G. R., Cook, J. J.
Published in Biopharmaceutics & drug disposition (01.11.1997)
Published in Biopharmaceutics & drug disposition (01.11.1997)
Get full text
Journal Article
Pharmacokinetics and pharmacodynamics of L-703,014, a potent fibrinogen receptor antagonist, after intravenous and oral administration in the dog
Barrett, J S, Gould, R J, Ellis, J D, Holahan, M M, Stranieri, M T, Lynch, Jr, J J, Hartman, G D, Ihle, N, Duggan, M, Moreno, O A
Published in Pharmaceutical research (01.03.1994)
Published in Pharmaceutical research (01.03.1994)
Get more information
Journal Article
Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs
Hutchinson, John H, Cook, Jacquelynn J, Brashear, Karen M, Breslin, Michael J, Glass, Joan D, Gould, Robert J, Halczenko, Wasyl, Holahan, Marie A, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Hartman, George D
Published in Journal of medicinal chemistry (08.11.1996)
Published in Journal of medicinal chemistry (08.11.1996)
Get full text
Journal Article
Effect of E-4031, a class III antiarrhythmic agent, on experimental infarct size in a canine model of myocardial ischemia-reperfusion injury
Holahan, M A, Stranieri, M T, Stabilito, I I, Lynch, Jr, J J
Published in Journal of cardiovascular pharmacology (01.06.1992)
Published in Journal of cardiovascular pharmacology (01.06.1992)
Get more information
Journal Article
Antiarrhythmic and antifibrillatory properties of McN-4130 in several animal models
Damiano, B P, Sit, S P, Fortunato, M A, Stranieri, M T, Brannan, M D
Published in Journal of cardiovascular pharmacology (01.05.1988)
Published in Journal of cardiovascular pharmacology (01.05.1988)
Get more information
Journal Article
Effects of the novel calcium channel blocker, McN-5691, on cardiocirculatory dynamics and cardiac output distribution in conscious spontaneously hypertensive rat
Flaim, S F, Stranieri, M T, Gill, A, Carson, J R, Brannan, M D
Published in Journal of cardiovascular pharmacology (01.04.1988)
Published in Journal of cardiovascular pharmacology (01.04.1988)
Get more information
Journal Article