PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?
Kenakin, Terry, Strachan, Ryan T.
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2018)
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2018)
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Journal Article
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Olsen, Reid H J, DiBerto, Jeffrey F, English, Justin G, Glaudin, Alexis M, Krumm, Brian E, Slocum, Samuel T, Che, Tao, Gavin, Ariana C, McCorvy, John D, Roth, Bryan L, Strachan, Ryan T
Published in Nature chemical biology (01.08.2020)
Published in Nature chemical biology (01.08.2020)
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Journal Article
Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors
Pironti, Gianluigi, Strachan, Ryan T, Abraham, Dennis, Mon-Wei Yu, Samuel, Chen, Minyong, Chen, Wei, Hanada, Kenji, Mao, Lan, Watson, Lewis J, Rockman, Howard A
Published in Circulation (New York, N.Y.) (16.06.2015)
Published in Circulation (New York, N.Y.) (16.06.2015)
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Journal Article
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
Staus, Dean P, Strachan, Ryan T, Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W, Kim, Tae Hun, Wingler, Laura M, Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C, Pardon, Els, Steyaert, Jan, Weis, William I, Prosser, R Scott, Kobilka, Brian K, Costa, Tommaso, Lefkowitz, Robert J
Published in Nature (London) (21.07.2016)
Published in Nature (London) (21.07.2016)
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Journal Article
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Che, Tao, Majumdar, Susruta, Zaidi, Saheem A., Ondachi, Pauline, McCorvy, John D., Wang, Sheng, Mosier, Philip D., Uprety, Rajendra, Vardy, Eyal, Krumm, Brian E., Han, Gye Won, Lee, Ming-Yue, Pardon, Els, Steyaert, Jan, Huang, Xi-Ping, Strachan, Ryan T., Tribo, Alexandra R., Pasternak, Gavril W., Carroll, F. Ivy, Stevens, Raymond C., Cherezov, Vadim, Katritch, Vsevolod, Wacker, Daniel, Roth, Bryan L.
Published in Cell (11.01.2018)
Published in Cell (11.01.2018)
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Journal Article
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells
English, Justin G., Olsen, Reid H.J., Lansu, Katherine, Patel, Michael, White, Karoline, Cockrell, Adam S., Singh, Darshan, Strachan, Ryan T., Wacker, Daniel, Roth, Bryan L.
Published in Cell (25.07.2019)
Published in Cell (25.07.2019)
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Journal Article
Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
Ahn, Seungkirl, Kahsai, Alem W., Pani, Biswaranjan, Wang, Qin-Ting, Zhao, Shuai, Wall, Alissa L., Strachan, Ryan T., Staus, Dean P., Wingler, Laura M., Sun, Lillian D., Sinnaeve, Justine, Choi, Minjung, Cho, Ted, Xu, Thomas T., Hansen, Gwenn M., Burnett, Michael B., Lamerdin, Jane E., Bassoni, Daniel L., Gavino, Bryant J., Husemoen, Gitte, Olsen, Eva K., Franch, Thomas, Costanzi, Stefano, Chen, Xin, Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2017)
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Journal Article
Rapid modulation of spine morphology by the 5-HT₂A serotonin receptor through kalirin-7 signaling
Jones, Kelly A, Srivastava, Deepak P, Allen, John A, Strachan, Ryan T, Roth, Bryan L, Penzes, Peter
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
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Journal Article
Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptor, Thereby Modulating 5-HT2A Signaling
Strachan, Ryan T., Sheffler, Douglas J., Willard, Belinda, Kinter, Michael, Kiselar, Janna G., Roth, Bryan L.
Published in The Journal of biological chemistry (27.02.2009)
Published in The Journal of biological chemistry (27.02.2009)
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Journal Article
Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor
Kahsai, Alem W, Wisler, James W, Lee, Jungmin, Ahn, Seungkirl, Cahill Iii, Thomas J, Dennison, S Moses, Staus, Dean P, Thomsen, Alex R B, Anasti, Kara M, Pani, Biswaranjan, Wingler, Laura M, Desai, Hemant, Bompiani, Kristin M, Strachan, Ryan T, Qin, Xiaoxia, Alam, S Munir, Sullenger, Bruce A, Lefkowitz, Robert J
Published in Nature chemical biology (11.07.2016)
Published in Nature chemical biology (11.07.2016)
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Journal Article
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
Foster, Simon R., Hauser, Alexander S., Vedel, Line, Strachan, Ryan T., Huang, Xi-Ping, Gavin, Ariana C., Shah, Sushrut D., Nayak, Ajay P., Haugaard-Kedström, Linda M., Penn, Raymond B., Roth, Bryan L., Bräuner-Osborne, Hans, Gloriam, David E.
Published in Cell (31.10.2019)
Published in Cell (31.10.2019)
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Journal Article
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
Thomsen, Alex R.B., Plouffe, Bianca, Cahill, Thomas J., Shukla, Arun K., Tarrasch, Jeffrey T., Dosey, Annie M., Kahsai, Alem W., Strachan, Ryan T., Pani, Biswaranjan, Mahoney, Jacob P., Huang, Liyin, Breton, Billy, Heydenreich, Franziska M., Sunahara, Roger K., Skiniotis, Georgios, Bouvier, Michel, Lefkowitz, Robert J.
Published in Cell (11.08.2016)
Published in Cell (11.08.2016)
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Journal Article
Autosomal dominant sacral agenesis: Currarino syndrome
Lynch, Sally Ann, Wang, Yiming, Strachan, T, Burn, John, Lindsay, Susan
Published in Journal of Medical Genetics (01.08.2000)
Published in Journal of Medical Genetics (01.08.2000)
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Journal Article
Book Review
Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin
Nobles, Kelly N, Xiao, Kunhong, Ahn, Seungkirl, Shukla, Arun K, Lam, Christopher M, Rajagopal, Sudarshan, Strachan, Ryan T, Huang, Teng-Yi, Bressler, Erin A, Hara, Makoto R, Shenoy, Sudha K, Gygi, Steven P, Lefkowitz, Robert J
Published in Science signaling (09.08.2011)
Published in Science signaling (09.08.2011)
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A genetic study of type 2 neurofibromatosis in the United Kingdom. I. Prevalence, mutation rate, fitness, and confirmation of maternal transmission effect on severity
Evans, D G, Huson, S M, Donnai, D, Neary, W, Blair, V, Teare, D, Newton, V, Strachan, T, Ramsden, R, Harris, R
Published in Journal of medical genetics (01.12.1992)
Published in Journal of medical genetics (01.12.1992)
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