Recent achievements in developing selective Gq inhibitors
Zhang, Hang, Nielsen, Alexander L., Strømgaard, Kristian
Published in Medicinal research reviews (01.01.2020)
Published in Medicinal research reviews (01.01.2020)
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Journal Article
Chemical Synthesis of PDZ Domains
Kossmann, Christin, Ma, Sana, Clemmensen, Louise S, Strømgaard, Kristian
Published in Methods in molecular biology (Clifton, N.J.) (2021)
Published in Methods in molecular biology (Clifton, N.J.) (2021)
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Journal Article
Development of Peptide-Based PDZ Domain Inhibitors
Essig, Dominik J, Balboa, Javier R, Strømgaard, Kristian
Published in Methods in molecular biology (Clifton, N.J.) (2021)
Published in Methods in molecular biology (Clifton, N.J.) (2021)
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Journal Article
Site-Specific Phosphorylation of PDZ Domains
Ma, Sana, Strømgaard, Kristian, Clemmensen, Louise S
Published in Methods in molecular biology (Clifton, N.J.) (2020)
Published in Methods in molecular biology (Clifton, N.J.) (2020)
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Journal Article
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity
Rem, Pascal Dominic, Sereikaite, Vita, Fernández-Fernández, Diego, Reinartz, Sebastian, Ulrich, Daniel, Fritzius, Thorsten, Trovo, Luca, Roux, Salomé, Chen, Ziyang, Rondard, Philippe, Pin, Jean-Philippe, Schwenk, Jochen, Fakler, Bernd, Gassmann, Martin, Barkat, Tania Rinaldi, Strømgaard, Kristian, Bettler, Bernhard
Published in eLife (23.01.2023)
Published in eLife (23.01.2023)
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Journal Article
Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin
Maric, Hans Michael, Kasaragod, Vikram Babu, Hausrat, Torben Johann, Kneussel, Matthias, Tretter, Verena, Strømgaard, Kristian, Schindelin, Hermann
Published in Nature communications (22.12.2014)
Published in Nature communications (22.12.2014)
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Journal Article
Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity
Malfacini, Davide, Patt, Julian, Annala, Suvi, Harpsøe, Kasper, Eryilmaz, Funda, Reher, Raphael, Crüsemann, Max, Hanke, Wiebke, Zhang, Hang, Tietze, Daniel, Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian, König, Gabriele M., Inoue, Asuka, Gomeza, Jesus, Kostenis, Evi
Published in The Journal of biological chemistry (12.04.2019)
Published in The Journal of biological chemistry (12.04.2019)
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Journal Article
Targeting receptor complexes: a new dimension in drug discovery
Rosenbaum, Mette Ishøy, Clemmensen, Louise S., Bredt, David S., Bettler, Bernhard, Strømgaard, Kristian
Published in Nature reviews. Drug discovery (01.12.2020)
Published in Nature reviews. Drug discovery (01.12.2020)
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Journal Article
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors
Voss, Jan H., Crüsemann, Max, Bartling, Christian R.O., Kehraus, Stefan, Inoue, Asuka, König, Gabriele M., Strømgaard, Kristian, Müller, Christa E.
Published in iScience (21.04.2023)
Published in iScience (21.04.2023)
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Journal Article
The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo
Al Humaidan, Emma Lisa, Pedersen, Sidse Lund, Burkhart, Annette, Rasmussen, Charlotte Laurfelt Munch, Moos, Torben, Fuchs, Peter, Fernandes, Eduardo Filipe Alves, Ozgür, Burak, Strømgaard, Kristian, Bach, Anders, Brodin, Birger, Kristensen, Mie
Published in Frontiers in Drug Delivery (06.04.2022)
Published in Frontiers in Drug Delivery (06.04.2022)
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Journal Article
SLC6 neurotransmitter transporters: structure, function, and regulation
Kristensen, Anders S, Andersen, Jacob, Jørgensen, Trine N, Sørensen, Lena, Eriksen, Jacob, Loland, Claus J, Strømgaard, Kristian, Gether, Ulrik
Published in Pharmacological reviews (01.09.2011)
Published in Pharmacological reviews (01.09.2011)
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Journal Article
Development of Potent Fluorescent Polyamine Toxins and Application in Labeling of Ionotropic Glutamate Receptors in Hippocampal Neurons
Nørager, Niels G, Jensen, Christel B, Rathje, Mette, Andersen, Jacob, Madsen, Kenneth L, Kristensen, Anders S, Strømgaard, Kristian
Published in ACS chemical biology (20.09.2013)
Published in ACS chemical biology (20.09.2013)
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Journal Article
Heparin promotes fibrillation of most phenol-soluble modulin virulence peptides from Staphylococcus aureus
Najarzadeh, Zahra, Zaman, Masihuz, Sereikaite, Vita, Strømgaard, Kristian, Andreasen, Maria, Otzen, Daniel E.
Published in The Journal of biological chemistry (01.08.2021)
Published in The Journal of biological chemistry (01.08.2021)
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Journal Article
Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities
Petersen, Jonas, Strømgaard, Kristian, Frølund, Bente, Clemmensen, Christoffer
Published in Drugs (New York, N.Y.) (01.07.2019)
Published in Drugs (New York, N.Y.) (01.07.2019)
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Journal Article
Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery
Li, Jian, Ge, Yang, Huang, Jun-Xiang, Strømgaard, Kristian, Zhang, Xiaolei, Xiong, Xiao-Feng
Published in Journal of medicinal chemistry (28.05.2020)
Published in Journal of medicinal chemistry (28.05.2020)
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Journal Article
PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression
Kucharz, Krzysztof, Søndergaard Rasmussen, Ida, Bach, Anders, Strømgaard, Kristian, Lauritzen, Martin
Published in Journal of cerebral blood flow and metabolism (01.05.2017)
Published in Journal of cerebral blood flow and metabolism (01.05.2017)
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Journal Article
high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage
Bach, Anders, Clausen, Bettina H, Møller, Magda, Vestergaard, Bente, Chi, Celestine N, Round, Adam, Sørensen, Pernille L, Nissen, Klaus B, Kastrup, Jette S, Gajhede, Michael, Jemth, Per, Kristensen, Anders S, Lundström, Patrik, Lambertsen, Kate L, Strømgaard, Kristian
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2012)
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Journal Article
Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms
Bleem, Alissa, Christiansen, Gunna, Madsen, Daniel J., Maric, Hans, Strømgaard, Kristian, Bryers, James D., Daggett, Valerie, Meyer, Rikke L., Otzen, Daniel E.
Published in Journal of molecular biology (12.10.2018)
Published in Journal of molecular biology (12.10.2018)
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Journal Article