Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons
Bilsland, Elizabeth, Tavella, Tatyana A, Krogh, Renata, Stokes, Jamie E, Roberts, Annabelle, Ajioka, James, Spring, David R, Andricopulo, Adriano D, Costa, Fabio T M, Oliver, Stephen G
Published in BMC biotechnology (11.04.2018)
Published in BMC biotechnology (11.04.2018)
Get full text
Journal Article
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2
Janeček, Matej, Rossmann, Maxim, Sharma, Pooja, Emery, Amy, Huggins, David J., Stockwell, Simon R., Stokes, Jamie E., Tan, Yaw S., Almeida, Estrella Guarino, Hardwick, Bryn, Narvaez, Ana J., Hyvönen, Marko, Spring, David R., McKenzie, Grahame J., Venkitaraman, Ashok R.
Published in Scientific reports (24.06.2016)
Published in Scientific reports (24.06.2016)
Get full text
Journal Article
A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles
Nie, Feilin, Kunciw, Dominique L., Wilcke, David, Stokes, Jamie E., Galloway, Warren R. J. D., Bartlett, Sean, Sore, Hannah F., Spring, David R.
Published in Angewandte Chemie International Edition (05.09.2016)
Published in Angewandte Chemie International Edition (05.09.2016)
Get full text
Journal Article
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
Sharma, Pooja, Mahen, Robert, Rossmann, Maxim, Stokes, Jamie E., Hardwick, Bryn, Huggins, David J., Emery, Amy, Kunciw, Dominique L., Hyvönen, Marko, Spring, David R., McKenzie, Grahame J., Venkitaraman, Ashok R.
Published in Scientific reports (04.11.2019)
Published in Scientific reports (04.11.2019)
Get full text
Journal Article
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction
Cole, Daniel J, Janecek, Matej, Stokes, Jamie E, Rossmann, Maxim, Faver, John C, McKenzie, Grahame J, Venkitaraman, Ashok R, Hyvönen, Marko, Spring, David R, Huggins, David J, Jorgensen, William L
Published in Chemical communications (Cambridge, England) (17.08.2017)
Published in Chemical communications (Cambridge, England) (17.08.2017)
Get full text
Journal Article
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
Chattopadhyay, Anasuya, O’Connor, Cornelius J., Zhang, Fengzhi, Galvagnion, Celine, Galloway, Warren R. J. D., Tan, Yaw Sing, Stokes, Jamie E., Rahman, Taufiq, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
Published in Scientific reports (05.04.2016)
Published in Scientific reports (05.04.2016)
Get full text
Journal Article
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
Ciardiello, Joe J., Galloway, Warren R.J.D., O'Connor, Cornelius J., Sore, Hannah F., Stokes, Jamie E., Wu, Yuteng, Spring, David R.
Published in Tetrahedron (23.06.2016)
Published in Tetrahedron (23.06.2016)
Get full text
Journal Article
Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction
Alza, Esther, Laraia, Luca, Ibbeson, Brett M, Collins, Súil, Galloway, Warren R J D, Stokes, Jamie E, Venkitaraman, Ashok R, Spring, David R
Published in Chemical science (Cambridge) (01.01.2015)
Published in Chemical science (Cambridge) (01.01.2015)
Get full text
Journal Article
Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis
Frei, Michelle S., Bilyard, Matthew K., Alanine, Thomas A., Galloway, Warren R.J.D., Stokes, Jamie E., Spring, David R.
Published in Bioorganic & medicinal chemistry (01.06.2015)
Published in Bioorganic & medicinal chemistry (01.06.2015)
Get full text
Journal Article
A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles
Nie, Feilin, Kunciw, Dominique L., Wilcke, David, Stokes, Jamie E., Galloway, Warren R. J. D., Bartlett, Sean, Sore, Hannah F., Spring, David R.
Published in Angewandte Chemie (05.09.2016)
Published in Angewandte Chemie (05.09.2016)
Get full text
Journal Article
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interactionElectronic supplementary information (ESI) available: Computational methods and structure files, chemical synthesis, fluorescence polarization assays, crystallographic data. See DOI: 10.1039/c7cc05379g
Cole, Daniel J, Janecek, Matej, Stokes, Jamie E, Rossmann, Maxim, Faver, John C, McKenzie, Grahame J, Venkitaraman, Ashok R, Hyvönen, Marko, Spring, David R, Huggins, David J, Jorgensen, William L
Year of Publication 17.08.2017
Year of Publication 17.08.2017
Get full text
Journal Article
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction† †Electronic supplementary information (ESI) available: Computational methods and structure files, chemical synthesis, fluorescence polarization assays, crystallographic data. See DOI: 10.1039/c7cc05379g
Cole, Daniel J., Janecek, Matej, Stokes, Jamie E., Rossmann, Maxim, Faver, John C., McKenzie, Grahame J., Venkitaraman, Ashok R., Hyvönen, Marko, Spring, David R., Huggins, David J., Jorgensen, William L.
Published in Chemical communications (Cambridge, England) (02.08.2017)
Published in Chemical communications (Cambridge, England) (02.08.2017)
Get full text
Journal Article
ChemInform Abstract: Synthesis of a Novel Polycyclic Ring Scaffold with Antimitotic Properties via a Selective Domino Heck-Suzuki Reaction
Alza, Esther, Laraia, Luca, Ibbeson, Brett M., Collins, Suil, Galloway, Warren R. J. D., Stokes, Jamie E., Venkitaraman, Ashok R., Spring, David R.
Published in ChemInform (01.06.2015)
Published in ChemInform (01.06.2015)
Get full text
Journal Article
New Advances in Diversity‐Oriented Synthesis
Galloway, Warren R. J. D, Stokes, Jamie E, Spring, David R
Published in Small Molecule Medicinal Chemistry (23.10.2015)
Published in Small Molecule Medicinal Chemistry (23.10.2015)
Get full text
Book Chapter
Synthesis of a novel polycyclic ring scaffold with antimitotic properties viaa selective domino Heck-Suzuki reaction
Alza, Esther, Laraia, Luca, Ibbeson, Brett M, Collins, Suil, Galloway, Warren RJD, Stokes, Jamie E, Venkitaraman, Ashok R, Spring, David R
Published in Chemical science (Cambridge) (01.12.2014)
Published in Chemical science (Cambridge) (01.12.2014)
Get full text
Journal Article
Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reactionElectronic supplementary information (ESI) available: Full experimental details, 1H and 13C NMR spectra and X-ray crystallographic data for compound 4d. CCDC 936207. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02547d
Alza, Esther, Laraia, Luca, Ibbeson, Brett M, Collins, Súil, Galloway, Warren R. J. D, Stokes, Jamie E, Venkitaraman, Ashok R, Spring, David R
Year of Publication 01.12.2014
Year of Publication 01.12.2014
Get full text
Journal Article
Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck–Suzuki reaction† †Electronic supplementary information (ESI) available: Full experimental details, 1H and 13C NMR spectra and X-ray crystallographic data for compound 4d. CCDC 936207. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02547d Click here for additional data file. Click here for additional data file
Alza, Esther, Laraia, Luca, Ibbeson, Brett M., Collins, Súil, Galloway, Warren R. J. D., Stokes, Jamie E., Venkitaraman, Ashok R., Spring, David R.
Published in Chemical science (Cambridge) (09.09.2014)
Published in Chemical science (Cambridge) (09.09.2014)
Get full text
Journal Article
Dynamic Combinatorial Chemistry with Novel Dithiol Building Blocks: Towards New Structurally Diverse and Adaptive Screening Collections
Postma, Tobias M., Galloway, Warren R. J. D., Cougnon, Fabien B. L., Pantos, G. Dan, Stokes, Jamie E., Spring, David R.
Published in Synlett (02.04.2013)
Published in Synlett (02.04.2013)
Get more information
Journal Article