Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11
Saulnier, Mark G, Balasubramanian, Balu N, Long, Byron H, Frennesson, David B, Ruediger, Edward, Zimmermann, Kurt, Eummer, Jeffrey T, St. Laurent, Denis R, Stoffan, Karen M, Naidu, B. Narasimhulu, Mahler, Mikael, Beaulieu, Francis, Bachand, Carol, Lee, Frank Y, Fairchild, Craig R, Stadnick, Linda K, Rose, William C, Solomon, Carola, Wong, Henry, Martel, Alain, Wright, John J, Kramer, Robert, Langley, David R, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
Get full text
Journal Article
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
Get full text
Journal Article
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Wright, John J, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
Get full text
Journal Article
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole-5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N., St. Laurent, Denis R., Saulnier, Mark G., Long, Byron H., Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R., Frennesson, David B., Kramer, Robert, Lee, Frank Y., Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C., Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M., Wong, Henry, Wright, John J., Zimmermann, Kurt, Vyas, Dolatrai M.
Published in Journal of medicinal chemistry (01.01.2005)
Published in Journal of medicinal chemistry (01.01.2005)
Get full text
Journal Article
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]- thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole- 5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N., St. Laurent, Denis R., Saulnier, Mark G., Long, Byron H., Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R., Frennesson, David B., Kramer, Robert, Lee, Frank Y., Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C., Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M., Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M.
Published in Journal of medicinal chemistry (01.03.2004)
Published in Journal of medicinal chemistry (01.03.2004)
Get full text
Journal Article
Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H, 13H-benzo[b]-thien yl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model
BALASUBRAMANIAN, Balu N, LAURENT, Denis R. St, FRENNESSON, David B, KRAMER, Robert, LEE, Frank Y, MAHLER, Mikael, MARTEL, Alain, NAIDU, B. Narasimhulu, ROSE, William C, RUSSELL, John, RUEDIGER, Edward, SOLOMON, Carola, SAULNIER, Mark G, STOFFAN, Karen M, WONG, Henry, ZIMMERMANN, Kurt, VYAS, Dolatrai M, LONG, Byron H, BACHAND, Carol, BEAULIEU, Francis, CLARKE, Wendy, DESHPANDE, Milind, EUMMER, Jeffrey, FAIRCHILD, Craig R
Published in Journal of medicinal chemistry (2004)
Get full text
Published in Journal of medicinal chemistry (2004)
Journal Article
A convenient cross-coupling route to α,β,γ,δ-unsaturated amino acids
Burk, Mark J., Allen, John G., Kiesman, William F., Stoffan, Karen M.
Published in Tetrahedron letters (24.02.1997)
Published in Tetrahedron letters (24.02.1997)
Get full text
Journal Article
NOVEL TYROSINE KINASES INHIBITORS
SANG, XIAOPENG, MARINIER, ANNE, LIU, PEIYING, TARRANT, JAMES, G, STOFFAN, KAREN, M, ZIMMERMANN, KURT, FRENNESSON, DAVID, B, SAULNIER, MARK, G, ROY, STEPHAN, WITTMAN, MARK, D, BALASUBRAMANIAN, NEELAKANTAN, VELAPARTHI, UPENDER
Year of Publication 10.03.2010
Get full text
Year of Publication 10.03.2010
Patent
NOVEL TYROSINE KINASE INHIBITORS
SANG, XIAOPENG, LIU, PEIYING, TARRANT, JAMES, G, STOFFAN, KAREN, M, ZIMMERMANN, KURT, FRENNESSON, DAVID, B, SAULNIER, MARK, G, WITTMAN, MARK, D, BALASUBRAMANIAN, NEELAKANTAN, VELAPARTHI, UPENDER
Year of Publication 19.03.2008
Get full text
Year of Publication 19.03.2008
Patent
Novel Tyrosine Kinase Inhibitors
SANG, XIAOPENG, TARRANT, JAMES, G, LIU, PEIYING, ZIMMERMAN, KURT, STOFFAN, KAREN, M, FRENNESSON, DAVID, B, SAULNIER, MARK, G, WITTMAN, MARK, D, BALASUBRAMANIAN, NEELAKANTAN, VELAPARTH, UPENDER
Year of Publication 10.11.2005
Get full text
Year of Publication 10.11.2005
Patent
NOVEL TYROSINE KINASE INHIBITORS
KAREN M. STOFFAN, MARK D. WITTMAN, XIAOPENG SANG, UPENDER VELAPARTHI, NEELAKANTAN BALASUBRAMANIAN, PEIYING LIU, KURT ZIMMERMANN, JAMES G. TARRANT, DAVID B. FRENNESSON, MARK G. SAULNIER
Year of Publication 31.08.2005
Get full text
Year of Publication 31.08.2005
Patent
NOVEL TYROSINE KINASE INHIBITORS
TARRANT JAMES G, SAULNIER MARK G, STOFFAN KAREN M, SANG XIAOPENG, LIU PEIYING, BALASUBRAMANIAN NEELAKANTAN, FRENNESSON DAVID B, WITTMAN MARK D, ZIMMERMANN KURT, VELAPARTHI UPENDER
Year of Publication 22.08.2005
Get full text
Year of Publication 22.08.2005
Patent
Tyrosine kinase inhibitors
Wittman, Mark D, Balasubramanian, Neelakantan, Velaparthi, Upender, Zimmermann, Kurt, Saulnier, Mark G, Liu, Peiying, Sang, Xiaopeng, Frennesson, David B, Stoffan, Karen M, Tarrant, James G, Marinier, Anne, Roy, Stephan
Year of Publication 29.05.2007
Get full text
Year of Publication 29.05.2007
Patent
Tyrosine kinase inhibitors
TARRANT JAMES G, MARINIER ANNE, SAULNIER MARK G, STOFFAN KAREN M, SANG XIAOPENG, ROY STEPHAN, LIU PEIYING, BALASUBRAMANIAN NEELAKANTAN, FRENNESSON DAVID B, WITTMAN MARK D, ZIMMERMANN KURT, VELAPARTHI UPENDER
Year of Publication 29.05.2007
Get full text
Year of Publication 29.05.2007
Patent
Novel tyrosine kinase inhibitors
KAREN M. STOFFAN, MARK D. WITTMAN, XIAOPENG SANG, UPENDER VELAPARTHI, NEELAKANTAN BALASUBRAMANIAN, PEIYING LIU, KURT ZIMMERMANN, JAMES G. TARRANT, DAVID B. FRENNESSON, MARK G. SAULNIER
Year of Publication 13.01.2005
Get full text
Year of Publication 13.01.2005
Patent
Tyrosine kinase inhibitors
Wittman, Mark D, Balasubramanian, Neelakantan, Velaparthi, Upender, Zimmermann, Kurt, Saulnier, Mark G, Liu, Peiying, Sang, Xiaopeng, Frennesson, David B, Stoffan, Karen M, Tarrant, James G, Marinier, Anne, Roy, Stephan
Year of Publication 25.07.2006
Get full text
Year of Publication 25.07.2006
Patent
Tyrosine kinase inhibitors
TARRANT JAMES G, MARINIER ANNE, SAULNIER MARK G, STOFFAN KAREN M, SANG XIAOPENG, ROY STEPHAN, LIU PEIYING, BALASUBRAMANIAN NEELAKANTAN, FRENNESSON DAVID B, WITTMAN MARK D, ZIMMERMANN KURT, VELAPARTHI UPENDER
Year of Publication 25.07.2006
Get full text
Year of Publication 25.07.2006
Patent
Novel tyrosine kinase inhibitors
TARRANT JAMES G, MARINIER ANNE, SAULNIER MARK G, STOFFAN KAREN M, SANG XIAOPENG, ROY STEPHAN, LIU PEIYING, BALASUBRAMANIAN NEELAKANTAN, FRENNESSON DAVID B, WITTMAN MARK D, ZIMMERMANN KURT, VELAPARTHI UPENDER
Year of Publication 13.04.2006
Get full text
Year of Publication 13.04.2006
Patent
CZ20032615
TARRANT JAMES G, SAULNIER SAULNIER, STOFFAN KAREN M, SANG XIAOPENG, LIU PEIYING, BALASUBRAMANIAN NEELAKANTAN, FRENNESSON DAVID B, WITTMAN MARK D, ZIMMERMANN KURT, VELAPARTHI UPENDER
Year of Publication 17.03.2004
Get full text
Year of Publication 17.03.2004
Patent
Türosiini kinaasi inhibiitorid, neid sisaldavad ravimkoostised ja nimetatud ühendid kasutamiseks haiguste ravis
KURT ZIMMERMAN, KAREN M. STOFFAN, MARK D. WITTMAN, XIAOPENG SANG, UPENDER VELAPARTHI, NEELAKANTAN BALASUBRAMANIAN, PEIYING LIU, JAMES G. TARRANT, DAVID B. FRENNESSON, MARK G. SAULNIER
Year of Publication 16.02.2004
Get full text
Year of Publication 16.02.2004
Patent