Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
Pidathala, Chandrakala, Amewu, Richard, Pacorel, Bénédicte, Nixon, Gemma L, Gibbons, Peter, Hong, W. David, Leung, Suet C, Berry, Neil G, Sharma, Raman, Stocks, Paul A, Srivastava, Abhishek, Shone, Alison E, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E, Warman, Ashley J, Biagini, Giancarlo A, Ward, Stephen A, O’Neill, Paul M
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs
Stocks, Paul A., Bray, Patrick G., Barton, Victoria E., Al‐Helal, Mohammed, Jones, Michael, Araujo, Nuna C., Gibbons, Peter, Ward, Stephen A., Hughes, Ruth H., Biagini, Giancarlo A., Davies, Jill, Amewu, Richard, Mercer, Amy E., Ellis, Gemma, O'Neill, Paul M.
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines
Chadwick, James, Jones, Michael, Mercer, Amy E., Stocks, Paul A., Ward, Stephen A., Park, B. Kevin, O’Neill, Paul M.
Published in Bioorganic & medicinal chemistry (01.04.2010)
Published in Bioorganic & medicinal chemistry (01.04.2010)
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Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex
Biagini, Giancarlo A, Fisher, Nicholas, Berry, Neil, Stocks, Paul A, Meunier, Brigitte, Williams, Dominic P, Bonar-Law, Richard, Bray, Patrick G, Owen, Andrew, O'Neill, Paul M, Ward, Stephen A
Published in Molecular pharmacology (01.05.2008)
Published in Molecular pharmacology (01.05.2008)
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Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century
O’Neill, Paul M, Park, B. Kevin, Shone, Alison E, Maggs, James L, Roberts, Phillip, Stocks, Paul A, Biagini, Giancarlo A, Bray, Patrick G, Gibbons, Peter, Berry, Neil, Winstanley, Peter A, Mukhtar, Amira, Bonar-Law, Richard, Hindley, Stephen, Bambal, Ramesh B, Davis, Charles B, Bates, Martin, Hart, Timothy K, Gresham, Stephanie L, Lawrence, Ron M, Brigandi, Richard A, Gomez-delas-Heras, Federico M, Gargallo, Domingo V, Ward, Stephen A
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
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PfCRT and the trans‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX
Bray, Patrick G., Mungthin, Mathirut, Hastings, Ian M., Biagini, Giancarlo A., Saidu, Dauda K., Lakshmanan, Viswanathan, Johnson, David J., Hughes, Ruth H., Stocks, Paul A., O'Neill, Paul M., Fidock, David A., Warhurst, David C., Ward, Stephen A.
Published in Molecular microbiology (01.10.2006)
Published in Molecular microbiology (01.10.2006)
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Antitumour and antimalarial activity of artemisinin-acridine hybrids
JONES, Michael, MERCER, Amy E, BRAY, Patrick G, RAWE, Sarah L, BAIRD, Jonathan, CHARIDZA, Tafadzwa, JANNEH, Omar, O'NEILL, Paul M, STOCKS, Paul A, LA PENSEE, Louise J. I, COSSTICK, Rick, PARK, B. Kevin, KENNEDY, Miriam E, PIANTANIDA, Ivo, WARD, Stephen A, DAVIES, Jill
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Design and Synthesis of Endoperoxide Antimalarial Prodrug Models
O'Neill, Paul M., Stocks, Paul A., Pugh, Matthew D., Araujo, Nuna C., Korshin, Edward E., Bickley, Jamie F., Ward, Stephen A., Bray, Patrick G., Pasini, Erica, Davies, Jill, Verissimo, Edite, Bachi, Mario D.
Published in Angewandte Chemie International Edition (13.08.2004)
Published in Angewandte Chemie International Edition (13.08.2004)
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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
Biagini, Giancarlo A, Fisher, Nicholas, Shone, Alison E, Mubaraki, Murad A, Srivastava, Abhishek, Hill, Alisdair, Antoine, Thomas, Warman, Ashley J, Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K, Leung, Suet C, Sharma, Raman, Gibbons, Peter, Hong, David W, Pacorel, Bénédicte, Lawrenson, Alexandre S, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A, Nixon, Gemma L, Chadwick, James, Hemingway, Janet, Delves, Michael J, Sinden, Robert E, Zeeman, Anne-Marie, Kocken, Clemens H. M, Berry, Neil G, O’Neill, Paul M, Ward, Stephen A
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2012)
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Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis
Hong, W. David, Gibbons, Peter D, Leung, Suet C, Amewu, Richard, Stocks, Paul A, Stachulski, Andrew, Horta, Pedro, Cristiano, Maria L. S, Shone, Alison E, Moss, Darren, Ardrey, Alison, Sharma, Raman, Warman, Ashley J, Bedingfield, Paul T. P, Fisher, Nicholas E, Aljayyoussi, Ghaith, Mead, Sally, Caws, Maxine, Berry, Neil G, Ward, Stephen A, Biagini, Giancarlo A, O’Neill, Paul M, Nixon, Gemma L
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Glutathione transport: a new role for PfCRT in chloroquine resistance
Patzewitz, Eva-Maria, Salcedo-Sora, J Enrique, Wong, Eleanor H, Sethia, Sonal, Stocks, Paul A, Maughan, Spencer C, Murray, James A H, Krishna, Sanjeev, Bray, Patrick G, Ward, Stephen A, Müller, Sylke
Published in Antioxidants & redox signaling (01.09.2013)
Published in Antioxidants & redox signaling (01.09.2013)
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Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
O' Neill, Paul M., Stocks, Paul A., Sabbani, Sunil, Roberts, Natalie L., Amewu, Richard K., Shore, Emma R., Aljayyoussi, Ghaith, Angulo-Barturén, Iñigo, Belén, María, Jiménez-Díaz, Bazaga, Santiago Ferrer, Martínez, María Santos, Campo, Brice, Sharma, Raman, Charman, Susan A., Ryan, Eileen, Chen, Gong, Shackleford, David M., Davies, Jill, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Published in Bioorganic & medicinal chemistry (15.07.2018)
Published in Bioorganic & medicinal chemistry (15.07.2018)
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The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters
Salcedo-Sora, J Enrique, Ochong, Edwin, Beveridge, Susan, Johnson, David, Nzila, Alexis, Biagini, Giancarlo A, Stocks, Paul A, O'Neill, Paul M, Krishna, Sanjeev, Bray, Patrick G, Ward, Stephen A
Published in The Journal of biological chemistry (30.12.2011)
Published in The Journal of biological chemistry (30.12.2011)
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Journal Article
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
Leung, Suet C, Gibbons, Peter, Amewu, Richard, Nixon, Gemma L, Pidathala, Chandrakala, Hong, W. David, Pacorel, Bénédicte, Berry, Neil G, Sharma, Raman, Stocks, Paul A, Srivastava, Abhishek, Shone, Alison E, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E, Warman, Ashley J, Biagini, Giancarlo A, Ward, Stephen A, O’Neill, Paul M
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles
Ellis, Gemma L, Amewu, Richard, Sabbani, Sunil, Stocks, Paul A, Shone, Alison, Stanford, Deborah, Gibbons, Peter, Davies, Jill, Vivas, Livia, Charnaud, Sarah, Bongard, Emily, Hall, Charlotte, Rimmer, Karen, Lozanom, Sonia, Jesús, María, Gargallo, Domingo, Ward, Stephen A, O’Neill, Paul M
Published in Journal of medicinal chemistry (10.04.2008)
Published in Journal of medicinal chemistry (10.04.2008)
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New 4-Aminoquinoline Mannich Base Antimalarials. 1. Effect of an Alkyl Substituent in the 5‘-Position of the 4‘-Hydroxyanilino Side Chain
Raynes, Kaylene J, Stocks, Paul A, O'Neill, Paul M, Park, B. Kevin, Ward, Stephen A
Published in Journal of medicinal chemistry (29.07.1999)
Published in Journal of medicinal chemistry (29.07.1999)
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Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines : synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates
ARAUJO, Nuna C. P, BARTON, Victoria, JONES, Michael, STOCKS, Paul A, WARD, Stephen A, DAVIES, Jill, BRAY, Patrick G, SHONE, Alison E, CRISTIANO, Maria L. S, O'NEILL, Paul M
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity
Gibbons, Peter, Verissimo, Edite, Araujo, Nuna C, Barton, Victoria, Nixon, Gemma L, Amewu, Richard K, Chadwick, James, Stocks, Paul A, Biagini, Giancarlo A, Srivastava, Abhishek, Rosenthal, Philip J, Gut, Jiri, Guedes, Rita C, Moreira, Rui, Sharma, Raman, Berry, Neil, Cristiano, M. Lurdes S, Shone, Alison E, Ward, Stephen A, O’Neill, Paul M
Published in Journal of medicinal chemistry (25.11.2010)
Published in Journal of medicinal chemistry (25.11.2010)
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Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable “Back-Up” Compound for N-tert-Butyl Isoquine
O’Neill, Paul M, Shone, Alison E, Stanford, Deborah, Nixon, Gemma, Asadollahy, Eghbaleh, Park, B. Kevin, Maggs, James L, Roberts, Phil, Stocks, Paul A, Biagini, Giancarlo, Bray, Patrick G, Davies, Jill, Berry, Neil, Hall, Charlotte, Rimmer, Karen, Winstanley, Peter A, Hindley, Stephen, Bambal, Ramesh B, Davis, Charles B, Bates, Martin, Gresham, Stephanie L, Brigandi, Richard A, Gomez-de-las-Heras, Federico M, Gargallo, Domingo V, Parapini, Silvia, Vivas, Livia, Lander, Hollie, Taramelli, Donatella, Ward, Stephen A
Published in Journal of medicinal chemistry (09.04.2009)
Published in Journal of medicinal chemistry (09.04.2009)
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