Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model
Kent, Caitlin N., Fulton, Mark G., Stillwell, Kaylee J., Dickerson, Jonathan W., Loch, Matthew T., Rodriguez, Alice L., Blobaum, Anna L., Boutaud, Olivier, Rook, Jerri L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
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Journal Article
Discovery of the First Selective M 4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy
Moehle, Mark S, Bender, Aaron M, Dickerson, Jonathan W, Foster, Daniel J, Qi, Aidong, Cho, Hyekyung P, Donsante, Yuping, Peng, Weimin, Bryant, Zoey, Stillwell, Kaylee J, Bridges, Thomas M, Chang, Sichen, Watson, Katherine J, O'Neill, Jordan C, Engers, Julie L, Peng, Li, Rodriguez, Alice L, Niswender, Colleen M, Lindsley, Craig W, Hess, Ellen J, Conn, P Jeffrey, Rook, Jerri M
Published in ACS pharmacology & translational science (13.08.2021)
Published in ACS pharmacology & translational science (13.08.2021)
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Journal Article
Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy
Moehle, Mark S, Bender, Aaron M, Dickerson, Jonathan W, Foster, Daniel J, Qi, Aidong, Cho, Hyekyung P, Donsante, Yuping, Peng, Weimin, Bryant, Zoey, Stillwell, Kaylee J, Bridges, Thomas M, Chang, Sichen, Watson, Katherine J, O’Neill, Jordan C, Engers, Julie L, Peng, Li, Rodriguez, Alice L, Niswender, Colleen M, Lindsley, Craig W, Hess, Ellen J, Conn, P. Jeffrey, Rook, Jerri M
Published in ACS pharmacology & translational science (13.08.2021)
Published in ACS pharmacology & translational science (13.08.2021)
Get full text
Journal Article
Discovery and optimization of a novel CNS penetrant series of mGlu(4) PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model
Kent, Caitlin N., Fulton, Mark G., Stillwell, Kaylee J., Dickerson, Jonathan W., Loch, Matthew T., Rodriguez, Alice L., Blobaum, Anna L., Boutaud, Olivier, Rook, Jerri L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
Get full text
Journal Article
Discovery and optimization of a novel CNS penetrant series of mGlu 4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model
Kent, Caitlin N, Fulton, Mark G, Stillwell, Kaylee J, Dickerson, Jonathan W, Loch, Matthew T, Rodriguez, Alice L, Blobaum, Anna L, Boutaud, Olivier, Rook, Jerri L, Niswender, Colleen M, Conn, P Jeffrey, Lindsley, Craig W
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
Get full text
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
Journal Article