A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refractory solid tumors
Kebenko, Maxim, Goebeler, Marie-Elisabeth, Wolf, Martin, Hasenburg, Annette, Seggewiss-Bernhardt, Ruth, Ritter, Barbara, Rautenberg, Beate, Atanackovic, Djordje, Kratzer, Andrea, Rottman, James B., Friedrich, Matthias, Vieser, Eva, Elm, Stefanie, Patzak, Ingrid, Wessiepe, Dorothea, Stienen, Sabine, Fiedler, Walter
Published in Oncoimmunology (01.01.2018)
Published in Oncoimmunology (01.01.2018)
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Pasotuxizumab, a BiTE ® immune therapy for castration-resistant prostate cancer: Phase I, dose-escalation study findings
Hummel, Horst-Dieter, Kufer, Peter, Grüllich, Carsten, Seggewiss-Bernhardt, Ruth, Deschler-Baier, Barbara, Chatterjee, Manik, Goebeler, Maria-Elisabeth, Miller, Kurt, de Santis, Maria, Loidl, Wolfgang, Dittrich, Christian, Buck, Andreas, Lapa, Constantin, Thurner, Annette, Wittemer-Rump, Sabine, Koca, Gökben, Boix, Oliver, Döcke, Wolf-Dietrich, Finnern, Ricarda, Kusi, Helena, Ajavon-Hartmann, Antoinette, Stienen, Sabine, Sayehli, Cyrus Michael, Polat, Bülent, Bargou, Ralf C
Published in Immunotherapy (01.02.2021)
Published in Immunotherapy (01.02.2021)
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Characterization and root cause analysis of immunogenicity to pasotuxizumab (AMG 212), a prostate-specific membrane antigen-targeting bispecific T-cell engager therapy
Penny, Hweixian Leong, Hainline, Kelly, Theoharis, Nathaniel, Wu, Bin, Brandl, Christian, Webhofer, Christian, McComb, Mason, Wittemer-Rump, Sabine, Koca, Gökben, Stienen, Sabine, Bargou, Ralf C., Hummel, Horst-Dieter, Loidl, Wolfgang, Grüllich, Carsten, Eggert, Tobias, Tran, Ben, Mytych, Daniel T.
Published in Frontiers in immunology (23.10.2023)
Published in Frontiers in immunology (23.10.2023)
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Biodistribution and PET Imaging of Labeled Bispecific T Cell-Engaging Antibody Targeting EpCAM
Warnders, Frank J, Waaijer, Stijn J H, Pool, Martin, Lub-de Hooge, Marjolijn N, Friedrich, Matthias, Terwisscha van Scheltinga, Anton G T, Deegen, Petra, Stienen, Sabine K, Pieslor, Peter C, Cheung, H Kam, Kosterink, Jos G W, de Vries, Elisabeth G E
Published in Journal of Nuclear Medicine (01.05.2016)
Published in Journal of Nuclear Medicine (01.05.2016)
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An Innovative Approach to Optimize First-In-Human Minimal Anticipated Biological Effect Level Based Starting Dose in Oncology Trials for Bispecific T-Cell Engagers: Experience from A Solid Tumor Bispecific T-Cell Engager
Zhou, Di, Kischel, Roman, Stienen, Sabine, Townsley, Danielle, Sternjak, Alexander, Lutteropp, Michael, Bailis, Julie, Friedrich, Matthias, Rattel, Benno, Mehta, Khamir, Upreti, Vijay V
Published in Clinical pharmacology and therapeutics (16.09.2024)
Published in Clinical pharmacology and therapeutics (16.09.2024)
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Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option
Stamm, Hauke, Klingler, Felix, Grossjohann, Eva-Maria, Muschhammer, Jana, Vettorazzi, Eik, Heuser, Michael, Mock, Ulrike, Thol, Felicitas, Vohwinkel, Gabi, Latuske, Emily, Bokemeyer, Carsten, Kischel, Roman, Dos Santos, Cedric, Stienen, Sabine, Friedrich, Matthias, Lutteropp, Michael, Nagorsen, Dirk, Wellbrock, Jasmin, Fiedler, Walter
Published in Oncogene (01.09.2018)
Published in Oncogene (01.09.2018)
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CLDN18.2 BiTE Engages Effector and Regulatory T Cells for Antitumor Immune Response in Preclinical Models of Pancreatic Cancer
Xu, Yao, Fu, Juan, Henderson, MacKenzie, Lee, Fei, Jurcak, Noelle, Henn, Anja, Wahl, Joachim, Shao, Yingkuan, Wang, Jianxin, Lyman, Melissa, Funes, Vanessa, Espinoza, Birginia, Zhang, Rui, Washington, India, Chen, Sophia Y., Zlomke, Haley, Wang, Junke, Niu, Nan, Li, Pan, Meng, Fengxi, Burns, William, Friedrich, Matthias, Stienen, Sabine, Bailis, Julie M., Zheng, Lei
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2023)
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2023)
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Abstract 1561: Evaluation of mesothelin BiTE® antibody constructs in models of pancreatic ductal adenocarcinoma
Jurcak, Noelle R., Zarecki, MacKenzie, Lee, Fei, Rozich, Noah, Muth, Stephen, Jaffee, Elizabeth, Stienen, Sabine, Bailis, Julie, Zheng, Lei
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 2769: PET imaging shows dose-dependent pharmacokinetics of a 89Zr-labeled mesothelin/CD3 half-life extended bispecific T-cell engager molecule in a syngeneic mouse model
Suurs, Frans V., Lorenczewski, Grit, Bailis, Julie M., Stienen, Sabine, Friedrich, Matthias, de Vries, Elisabeth G.E., de Groot, Derk Jan A., Lub-de Hooge, Marjolijn N.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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The Biodistribution of a CD3 and EpCAM Bispecific T-Cell Engager Is Driven by the CD3 Arm
Suurs, Frans V, Lorenczewski, Grit, Stienen, Sabine, Friedrich, Matthias, de Vries, Elisabeth G E, de Groot, Derk Jan A, Lub-de Hooge, Marjolijn N
Published in Journal of Nuclear Medicine (01.11.2020)
Published in Journal of Nuclear Medicine (01.11.2020)
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Mesothelin/CD3 half-life extended bispecific T-cell engager molecule shows specific tumor uptake and distributes to mesothelin and CD3 expressing tissues
Suurs, Frans V, Lorenczewski, Grit, Bailis, Julie M, Stienen, Sabine, Friedrich, Matthias, Lee, Fei, van der Vegt, Bert, de Vries, Elisabeth G E, de Groot, Derk-Jan A, Lub-de Hooge, Marjolijn N
Published in Journal of Nuclear Medicine (01.12.2021)
Published in Journal of Nuclear Medicine (01.12.2021)
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Abstract 1134: PET-imaging of 89Zr-labeled bispecific T-cell engagers in syngeneic tumor bearing mice
Suurs, Frans V., Groot, Derk J. de, Domanska, Urszula M., Lorenczewski, Grit, Stienen, Sabine, Friedrich, Matthias, Vries, Elisabeth G. de, Hooge, Marjolijn N. Lub-de
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Novel anti-EGFRvIII bispecific T cell engager (BiTE) antibody construct in glioblastoma (GBM): Trial in progress of AMG 596 in patients with recurrent or newly diagnosed disease
Rosenthal, Mark, Balana, Carmen, Van Linde, Myra Ellen, Sayehli, Cyrus, Fiedler, Walter M., Wermke, Martin, Massard, Christophe, Ang, Agnes, Kast, Johannes, Stienen, Sabine, Cloughesy, Timothy Francis
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Phase I study of pasotuxizumab (AMG 212/BAY 2010112), a PSMA-targeting BiTE (Bispecific T-cell Engager) immune therapy for metastatic castration-resistant prostate cancer (mCRPC)
Hummel, Horst-Dieter, Kufer, Peter, Grüllich, Carsten, Deschler-Baier, Barbara, Chatterjee, Manik, Goebeler, Maria-Elisabeth, Miller, Kurt, De Santis, Maria, Loidl, Wolfgang C., Buck, Andreas, Wittemer-Rump, Sabine, Koca, Goekben, Boix, Oliver, Doecke, Wolf-Dietrich, Stienen, Sabine, Sayehli, Cyrus, Bargou, Ralf C.
Published in Journal of clinical oncology (20.02.2020)
Published in Journal of clinical oncology (20.02.2020)
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Abstract 3630: Preclinical evaluation of a BiTE® antibody construct with extended half-life that targets the tumor differentiation marker mesothelin
Sternjak, Alexander, Lee, Fei, Wahl, Joachim, Rock, Dan, Thomas, Oliver, Stienen, Sabine, Lutterbuese, Ralf, Hoffmann, Patrick, Raum, Tobias, Kufer, Peter, Rattel, Benno, Coxon, Angela, Friedrich, Matthias, Bailis, Julie
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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ATIM-49 (LTBK-01). AMG 596, A NOVEL ANTI-EGFRVIII BISPECIFIC T CELL ENGAGER (BITE®) MOLECULE FOR THE TREATMENT OF GLIOBLASTOMA (GBM): PLANNED INTERIM ANALYSIS IN RECURRENT GBM (RGBM)
Rosenthal, Mark A, Balana, Carmen, van Linde, Myra E, Sayehli, Cyrus, Fiedler, Walter M, Wermke, Martin, Massard, Christophe, Mellinghoff, Ingo K, Khasraw, Mustafa, Ang, Agnes, Rasmussen, Erik, Kast, Johannes, Stienen, Sabine, Cloughesy, Timothy F
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
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Phase 1 study of pasotuxizumab (BAY 2010112), a PSMA-targeting Bispecific T cell Engager (BiTE) immunotherapy for metastatic castration-resistant prostate cancer (mCRPC)
Hummel, Horst-Dieter, Kufer, Peter, Grüllich, Carsten, Deschler-Baier, Barbara, Chatterjee, Manik, Goebeler, Maria-Elisabeth, Miller, Kurt, De Santis, Maria, Loidl, Wolfgang C., Buck, Andreas, Wittemer-Rump, Sabine, Koca, Goekben, Boix, Oliver, Doecke, Wolf-Dietrich, Stienen, Sabine, Sayehli, Cyrus, Bargou, Ralf C.
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Molecular Imaging of Radiolabeled Bispecific T-Cell Engager 89Zr-AMG211 Targeting CEA-Positive Tumors
Waaijer, Stijn J.H., Warnders, Frank J., Stienen, Sabine, Friedrich, Matthias, Sternjak, Alexander, Cheung, H. Kam, van Scheltinga, Anton G.T. Terwisscha, Schröder, Carolien P., de Vries, Elisabeth G.E., Lub-de Hooge, Marjolijn N.
Published in Clinical cancer research (15.10.2018)
Published in Clinical cancer research (15.10.2018)
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