Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses
Yoon, Jeong-Joong, Toots, Mart, Lee, Sujin, Lee, Myung-Eun, Ludeke, Barbara, Luczo, Jasmina M, Ganti, Ketaki, Cox, Robert M, Sticher, Zachary M, Edpuganti, Vindya, Mitchell, Deborah G, Lockwood, Mark A, Kolykhalov, Alexander A, Greninger, Alexander L, Moore, Martin L, Painter, George R, Lowen, Anice C, Tompkins, Stephen M, Fearns, Rachel, Natchus, Michael G, Plemper, Richard K
Published in Antimicrobial agents and chemotherapy (01.08.2018)
Published in Antimicrobial agents and chemotherapy (01.08.2018)
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The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection
Painter, George R., Bowen, Richard A., Bluemling, Gregory R., DeBergh, John, Edpuganti, Vindhya, Gruddanti, Prabhakar R., Guthrie, David B., Hager, Michael, Kuiper, Damien L., Lockwood, Mark A., Mitchell, Deborah G., Natchus, Michael G., Sticher, Zachary M., Kolykhalov, Alexander A.
Published in Antiviral research (01.11.2019)
Published in Antiviral research (01.11.2019)
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SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model
Lieber, Carolin M., Cox, Robert M., Sourimant, Julien, Wolf, Josef D., Juergens, Kate, Phung, Quynh, Saindane, Manohar T., Smith, Meghan K., Sticher, Zachary M., Kalykhalov, Alexander A., Natchus, Michael G., Painter, George R., Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.
Published in Nature communications (29.07.2022)
Published in Nature communications (29.07.2022)
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Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models
Cox, Robert M., Lieber, Carolin M., Wolf, Josef D., Karimi, Amirhossein, Lieberman, Nicole A. P., Sticher, Zachary M., Roychoudhury, Pavitra, Andrews, Meghan K., Krueger, Rebecca E., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A., Greninger, Alexander L., Plemper, Richard K.
Published in Nature communications (07.08.2023)
Published in Nature communications (07.08.2023)
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Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets
Cox, Robert M., Wolf, Josef D., Lieberman, Nicole A., Lieber, Carolin M., Kang, Hae-Ji, Sticher, Zachary M., Yoon, Jeong-Joong, Andrews, Meghan K., Govindarajan, Mugunthan, Krueger, Rebecca E., Sobolik, Elizabeth B., Natchus, Michael G., Gewirtz, Andrew T., deSwart, Rik L., Kolykhalov, Alexander A., Hekmatyar, Khan, Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.
Published in Nature communications (08.02.2024)
Published in Nature communications (08.02.2024)
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4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses
Lieber, Carolin M, Aggarwal, Megha, Yoon, Jeong-Joong, Cox, Robert M, Kang, Hae-Ji, Sourimant, Julien, Toots, Mart, Johnson, Scott K, Jones, Cheryl A, Sticher, Zachary M, Kolykhalov, Alexander A, Saindane, Manohar T, Tompkins, Stephen M, Planz, Oliver, Painter, George R, Natchus, Michael G, Sakamoto, Kaori, Plemper, Richard K
Published in PLoS pathogens (17.04.2023)
Published in PLoS pathogens (17.04.2023)
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Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
Wittwer, Kevin, Anderson, Danielle E., Pfeffermann, Kristin, Cox, Robert M., Wolf, Josef D., Santibanez, Sabine, Mankertz, Annette, Plesker, Roland, Sticher, Zachary M., Kolkykhalov, Alexander A., Natchus, Michael G., Pfaller, Christian K., Plemper, Richard K., von Messling, Veronika
Published in Nature communications (02.09.2021)
Published in Nature communications (02.09.2021)
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Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia
Toots, Mart, Yoon, Jeong-Joong, Cox, Robert M, Hart, Michael, Sticher, Zachary M, Makhsous, Negar, Plesker, Roland, Barrena, Alec H, Reddy, Prabhakar G, Mitchell, Deborah G, Shean, Ryan C, Bluemling, Gregory R, Kolykhalov, Alexander A, Greninger, Alexander L, Natchus, Michael G, Painter, George R, Plemper, Richard K
Published in Science translational medicine (23.10.2019)
Published in Science translational medicine (23.10.2019)
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Efficacy of late-onset antiviral treatment in immunocompromised hosts with persistent SARS-CoV-2 infection
Lieber, Carolin M, Kang, Hae-Ji, Sobolik, Elizabeth B, Sticher, Zachary M, Ngo, Vu L, Gewirtz, Andrew T, Kolykhalov, Alexander A, Natchus, Michael G, Greninger, Alexander L, Suthar, Mehul S, Plemper, Richard K
Published in Journal of virology (17.09.2024)
Published in Journal of virology (17.09.2024)
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ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens
Squires, Katherine E, Mayers, Douglas L, Bluemling, Gregory R, Kolykhalov, Alexander A, Guthrie, David B, Reddy, Prabhakar, Mitchell, Debbie G, Saindane, Manohar T, Sticher, Zachary M, Edpuganti, Vindhya, De La Rosa, Abel
Published in Antimicrobial agents and chemotherapy (20.08.2020)
Published in Antimicrobial agents and chemotherapy (20.08.2020)
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Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function
Sticher, Zachary M, Lu, Gaofei, Mitchell, Deborah G, Marlow, Joshua, Moellering, Levi, Bluemling, Gregory R, Guthrie, David B, Natchus, Michael G, Painter, George R, Kolykhalov, Alexander A
Published in Antimicrobial agents and chemotherapy (27.01.2020)
Published in Antimicrobial agents and chemotherapy (27.01.2020)
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Analysis of the Potential for N4-Hydroxycytidine To Inhibit Mitochondrial Replication and Function
Sticher, Zachary M, Lu, Gaofei, Mitchell, Deborah G, Marlow, Joshua, Moellering, Levi, Bluemling, Gregory R, Guthrie, David B, Natchus, Michael G, Painter, George R, Kolykhalov, Alexander A
Published in Antimicrobial agents and chemotherapy (27.01.2020)
Published in Antimicrobial agents and chemotherapy (27.01.2020)
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Delayed low-dose oral administration of 4'-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease
Welch, Stephen R, Spengler, Jessica R, Westover, Jonna B, Bailey, Kevin W, Davies, Katherine A, Aida-Ficken, Virginia, Bluemling, Gregory R, Boardman, Kirsten M, Wasson, Samantha R, Mao, Shuli, Kuiper, Damien L, Hager, Michael W, Saindane, Manohar T, Andrews, Meghan K, Krueger, Rebecca E, Sticher, Zachary M, Jung, Kie Hoon, Chatterjee, Payel, Shrivastava-Ranjan, Punya, Lo, Michael K, Coleman-McCray, JoAnn D, Sorvillo, Teresa E, Genzer, Sarah C, Scholte, Florine E M, Kelly, Jamie A, Jenks, M Harley, McMullan, Laura K, Albariño, César G, Montgomery, Joel M, Painter, George R, Natchus, Michael G, Kolykhalov, Alexander A, Gowen, Brian B, Spiropoulou, Christina F, Flint, Mike
Published in Science translational medicine (20.11.2024)
Published in Science translational medicine (20.11.2024)
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Design and Optimization of Novel Competitive, Non-peptidic, SARS-CoV‑2 Mpro Inhibitors
Jacobs, Leon, van der Westhuyzen, Aletta, Pribut, Nicole, Dentmon, Zackery W., Cui, Dan, D’Erasmo, Michael P., Bartsch, Perry W., Liu, Ken, Cox, Robert M., Greenlund, Sujay F., Plemper, Richard K., Mitchell, Deborah, Marlow, Joshua, Andrews, Meghan K., Krueger, Rebecca E., Sticher, Zachary M., Kolykhalov, Alexander A., Natchus, Michael G., Zhou, Bin, Pelly, Stephen C., Liotta, Dennis C.
Published in ACS medicinal chemistry letters (12.10.2023)
Published in ACS medicinal chemistry letters (12.10.2023)
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Design and Optimization of Novel Competitive, Non-peptidic, SARS-CoV-2 M pro Inhibitors
Jacobs, Leon, van der Westhuyzen, Aletta, Pribut, Nicole, Dentmon, Zackery W, Cui, Dan, D'Erasmo, Michael P, Bartsch, Perry W, Liu, Ken, Cox, Robert M, Greenlund, Sujay F, Plemper, Richard K, Mitchell, Deborah, Marlow, Joshua, Andrews, Meghan K, Krueger, Rebecca E, Sticher, Zachary M, Kolykhalov, Alexander A, Natchus, Michael G, Zhou, Bin, Pelly, Stephen C, Liotta, Dennis C
Published in ACS medicinal chemistry letters (12.10.2023)
Published in ACS medicinal chemistry letters (12.10.2023)
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Efficacy of late-onset antiviral treatment in immune-compromised hosts with persistent SARS-CoV-2 infection
Lieber, Carolin M, Kang, Hae-Ji, Sobolik, Elizabeth B, Sticher, Zachary M, Ngo, Vu L, Gewirtz, Andrew T, Kolykhalov, Alexander A, Natchus, Michael G, Greninger, Alexander L, Suthar, Mehul S, Plemper, Richard K
Published in bioRxiv (23.05.2024)
Published in bioRxiv (23.05.2024)
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