Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors
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Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes
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Structure-Based Characterization and Optimization of Novel Hydrophobic Binding Interactions in a Series of Pyrrolidine Influenza Neuraminidase Inhibitors
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Schluckebier, Gerd, Zhong, Ping, Stewart, Kent D, Kavanaugh, Tom J, Abad-Zapatero, Cele
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In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 Variants with Increased Resistance to ABT-378, a Novel Protease Inhibitor
Carrillo, A, Stewart, K D, Sham, H L, Norbeck, D W, Kohlbrenner, W E, Leonard, J M, Kempf, D J, Molla, A
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Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2- c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors
Akritopoulou-Zanze, Irini, Albert, Daniel H., Bousquet, Peter F., Cunha, George A., Harris, Christopher M., Moskey, Maria, Dinges, Jurgen, Stewart, Kent D., Sowin, Thomas J.
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Conserved residues in the coiled-coil pocket of human immunodeficiency virus type 1 gp41 are essential for viral replication and interhelical interaction
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Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives
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Published in Bioorganic & medicinal chemistry (15.07.2008)
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Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases
Ji, Zhiqin, Ahmed, Asma A., Albert, Daniel H., Bouska, Jennifer J., Bousquet, Peter F., Cunha, George A., Glaser, Keith B., Guo, Jun, Li, Junling, Marcotte, Patrick A., Moskey, Maria D., Pease, Lori J., Stewart, Kent D., Yates, Melinda, Davidsen, Steven K., Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Hit-to-lead optimization of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of KDR kinase inhibitors
Dinges, Jürgen, Akritopoulou-Zanze, Irini, Arnold, Lee D., Barlozzari, Teresa, Bousquet, Peter F., Cunha, George A., Ericsson, Anna M., Iwasaki, Nobuhiko, Michaelides, Michael R., Ogawa, Nobuo, Phelan, Kathleen M., Rafferty, Paul, Sowin, Thomas J., Stewart, Kent D., Tokuyama, Ryukou, Xia, Zhiren, Zhang, Henry Q.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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1,4-Dihydroindeno[1,2- c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors
Dinges, Jürgen, Ashworth, Kimba L., Akritopolou-Zanze, Irini, Arnold, Lee D., Baumeister, Steven A., Bousquet, Peter F., Cunha, George A., Davidsen, Steven K., Djuric, Stevan W., Gracias, Vijaya J., Michaelides, Michael R., Rafferty, Paul, Sowin, Thomas J., Stewart, Kent D., Xia, Zhiren, Zhang, Henry Q.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core
Wang, Gary T., Wang, Sheldon, Gentles, Robert, Sowin, Thomas, Maring, Clarence J., Kempf, Dale J., Kati, Warren M., Stoll, Vincent, Stewart, Kent D., Laver, Graeme
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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1,4-Dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies
Tong, Yunsong, Claiborne, Akiyo, Pyzytulinska, Magdalena, Tao, Zhi-Fu, Stewart, Kent D., Kovar, Peter, Chen, Zehan, Credo, Robert B., Guan, Ran, Merta, Philip J., Zhang, Haiying, Bouska, Jennifer, Everitt, Elizabeth A., Murry, Bernard P., Hickman, Dean, Stratton, Tim J., Wu, Jian, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability
Tong, Yunsong, Przytulinska, Magdalena, Tao, Zhi-Fu, Bouska, Jennifer, Stewart, Kent D., Park, Chang, Li, Gaoquan, Claiborne, Akiyo, Kovar, Peter, Chen, Zehan, Merta, Philip J., Bui, Mai-Ha, Olson, Amanda, Osterling, Donald, Zhang, Haiying, Sham, Hing L., Rosenberg, Saul H., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Isoindolinone ureas: a novel class of KDR kinase inhibitors
Curtin, Michael L, Frey, Robin R, Heyman, H.Robin, Sarris, Kathy A, Steinman, Douglas H, Holmes, James H, Bousquet, Peter F, Cunha, George A, Moskey, Maria D, Ahmed, Asma A, Pease, Lori J, Glaser, Keith B, Stewart, Kent D, Davidsen, Steven K, Michaelides, Michael R
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
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Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains
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Published in Bioorganic & medicinal chemistry letters (15.12.2005)
Published in Bioorganic & medicinal chemistry letters (15.12.2005)
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Establishment and Characterization of 7 New Monoclonal Antibodies to Tissue Inhibitor of Metalloproteinases-1
Møller Sørensen, Nanna, Dowell, Barry L., Stewart, Kent D., Jensen, Vibeke, Larsen, Lise, Lademann, Ulrik, Murphy, Gillian, Nielsen, Hans Jørgen, Brünner, Nils, Davis, Gerard J.
Published in Tumor biology (01.03.2005)
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Synthesis of an Influenza Neuraminidase Inhibitor Intermediate via a Highly Diastereoselective Coupling Reaction
Barnes, David M, McLaughlin, Maureen A, Oie, Tetsuro, Rasmussen, Michael W, Stewart, Kent D, Wittenberger, Steven J
Published in Organic letters (02.05.2002)
Published in Organic letters (02.05.2002)
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