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Published in Journal of medicinal chemistry (05.04.2007)
Published in Journal of medicinal chemistry (05.04.2007)
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Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases
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Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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Thienopyrimidine Ureas as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors
Dai, Yujia, Guo, Yan, Frey, Robin R, Ji, Zhiqin, Curtin, Michael L, Ahmed, Asma A, Albert, Daniel H, Arnold, Lee, Arries, Shannon S, Barlozzari, Teresa, Bauch, Joy L, Bouska, Jennifer J, Bousquet, Peter F, Cunha, George A, Glaser, Keith B, Guo, Jun, Li, Junling, Marcotte, Patrick A, Marsh, Kennan C, Moskey, Maria D, Pease, Lori J, Stewart, Kent D, Stoll, Vincent S, Tapang, Paul, Wishart, Neil, Davidsen, Steven K, Michaelides, Michael R
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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Transforming Growth Factor β Mimetics: Discovery of 7-[4-(4-Cyanophenyl) phenoxy]-Heptanohydroxamic Acid, a Biaryl Hydroxamate Inhibitor of Histone Deacetylase
Glaser, Keith B, Li, Junling, Aakre, Mary E, Morgan, Douglas W, Sheppard, George, Stewart, Kent D, Pollock, Jennifer, Lee, Paul, O'Connor, Chad Z, Anderson, Steven N, Mussatto, Donna J, Wegner, Craig W, Moses, Harold L
Published in Molecular cancer therapeutics (01.08.2002)
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Published in Molecular cancer therapeutics (01.08.2002)
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Isoxazolo[3,4- b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling
Tong, Yunsong, Stewart, Kent D., Thomas, Sheela, Przytulinska, Magdalena, Johnson, Eric F., Klinghofer, Vered, Leverson, Joel, McCall, Owen, Soni, Niru B., Luo, Yan, Lin, Nan-horng, Sowin, Thomas J., Giranda, Vincent L., Penning, Thomas D.
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
Fidanze, Steve D., Erickson, Scott A., Wang, Gary T., Mantei, Robert, Clark, Richard F., Sorensen, Bryan K., Bamaung, Nwe Y., Kovar, Peter, Johnson, Eric F., Swinger, Kerren K., Stewart, Kent D., Zhang, Qian, Tucker, Lora A., Pappano, William N., Wilsbacher, Julie L., Wang, Jieyi, Sheppard, George S., Bell, Randy L., Davidsen, Steven K., Hubbard, Robert D.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties
Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Zheng, Guo Zhu, Perner, Richard J, Didomenico, Stanley, Koenig, John R, Turner, Sean, Jinkerson, Tammie, Drizin, Irene, Hannick, Steven M, Macri, Bryan S, McDonald, Heath A, Honore, Prisca, Wismer, Carol T, Marsh, Kennan C, Wetter, Jill, Stewart, Kent D, Oie, Tetsuro, Jarvis, Michael F, Surowy, Carol S, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (10.02.2005)
Published in Journal of medicinal chemistry (10.02.2005)
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7-Aminopyrazolo[1,5-a]pyrimidines as Potent Multitargeted Receptor Tyrosine Kinase Inhibitors
Frey, Robin R, Curtin, Michael L, Albert, Daniel H, Glaser, Keith B, Pease, Lori J, Soni, Niru B, Bouska, Jennifer J, Reuter, David, Stewart, Kent D, Marcotte, Patrick, Bukofzer, Gail, Li, Junling, Davidsen, Steven K, Michaelides, Michael R
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors
Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W, Longenecker, Kenton, Pireh, Daisy, Stewart, Kent D, Backes, Bradley J, Lai, Chunqiu, Lubben, Thomas H, Ballaron, Stephen J, Beno, David W. A, Kempf-Grote, Anita J, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (19.04.2007)
Published in Journal of medicinal chemistry (19.04.2007)
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Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors
Zhang, Qingwei, Xia, Zhiren, Mitten, Michael J., Lasko, Loren M., Klinghofer, Vered, Bouska, Jennifer, Johnson, Eric F., Penning, Thomas D., Luo, Yan, Giranda, Vincent L., Shoemaker, Alexander R., Stewart, Kent D., Djuric, Stevan W., Vasudevan, Anil
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families
Curtin, Michael L., Frey, Robin R., Heyman, H. Robin, Soni, Niru B., Marcotte, Patrick A., Pease, Lori J., Glaser, Keith B., Magoc, Terrance J., Tapang, Paul, Albert, Daniel H., Osterling, Donald J., Olson, Amanda M., Bouska, Jennifer J., Guan, Zhiwen, Preusser, Lee C., Polakowski, James S., Stewart, Kent D., Tse, Chris, Davidsen, Steven K., Michaelides, Michael R.
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Synthesis and Biological Characterization of B-Ring Amino Analogues of Potent Benzothiadiazine Hepatitis C Virus Polymerase Inhibitors
Randolph, John T, Flentge, Charles A, Huang, Peggy P, Hutchinson, Douglas K, Klein, Larry L, Lim, Hock B, Mondal, Rubina, Reisch, Thomas, Montgomery, Debra A, Jiang, Wen W, Masse, Sherie V, Hernandez, Lisa E, Henry, Rodger F, Liu, Yaya, Koev, Gennadiy, Kati, Warren M, Stewart, Kent D, Beno, David W. A, Molla, Akhteruzzaman, Kempf, Dale J
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases
Curtin, Michael L., Robin Heyman, H., Frey, Robin R., Marcotte, Patrick A., Glaser, Keith B., Jankowski, James R., Magoc, Terrance J., Albert, Daniel H., Olson, Amanda M., Reuter, David R., Bouska, Jennifer J., Montgomery, Debra A., Palma, Joann P., Donawho, Cherrie K., Stewart, Kent D., Tse, Chris, Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
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Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket
Stewart, Kent D., Huth, Jeffrey R., Ng, Teresa I., McDaniel, Keith, Hutchinson, Rebecca Newlin, Stoll, Vincent S., Mendoza, Renaldo R., Matayoshi, Edmund D., Carrick, Robert, Mo, HongMei, Severin, Jean, Walter, Karl, Richardson, Paul L., Barrett, Leo W., Meadows, Robert, Anderson, Steve, Kohlbrenner, William, Maring, Clarence, Kempf, Dale J., Molla, Akhter, Olejniczak, Edward T.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
Krueger, A. Chris, Randolph, John T., DeGoey, David A., Donner, Pamela L., Flentge, Charles A., Hutchinson, Douglas K., Liu, Dachun, Motter, Christopher E., Rockway, Todd W., Wagner, Rolf, Beno, David W.A., Koev, Gennadiy, Lim, Hock B., Beyer, Jill M., Mondal, Rubina, Liu, Yaya, Kati, Warren M., Longenecker, Kenton L., Molla, Akhteruzzaman, Stewart, Kent D., Maring, Clarence J.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Contribution of indazolinone tautomers to kinase activity
Vasudevan, Anil, Verzal, Mary K., Villamil, Clara I., Stewart, Kent D., Abad-Zapatero, Cele, Oie, Tetsuro, Djuric, Stevan W.
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
Published in Bioorganic & medicinal chemistry letters (15.07.2012)
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Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series
Stoll, Vincent, Stewart, Kent D, Maring, Clarence J, Muchmore, Steven, Giranda, Vincent, Gu, Yu-gui Y, Wang, Gary, Chen, Yuanwei, Sun, Minghua, Zhao, Chen, Kennedy, April L, Madigan, Darold L, Xu, Yibo, Saldivar, Ayda, Kati, Warren, Laver, Graeme, Sowin, Thomas, Sham, Hing L, Greer, Jonathan, Kempf, Dale
Published in Biochemistry (Easton) (28.01.2003)
Published in Biochemistry (Easton) (28.01.2003)
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3-Amino-benzo[d]isoxazoles as Novel Multitargeted Inhibitors of Receptor Tyrosine Kinases
Ji, Zhiqin, Ahmed, Asma A, Albert, Daniel H, Bouska, Jennifer J, Bousquet, Peter F, Cunha, George, A, Diaz, Gilbert, Glaser, Keith B, Guo, Jun, Harris, Christopher M, Li, Junling, Marcotte, Patrick A, Moskey, Maria D, Oie, Tetsuro, Pease, Lori, Soni, Nirupama B, Stewart, Kent D, Davidsen, Steven K, Michaelides, Michael R
Published in Journal of medicinal chemistry (13.03.2008)
Published in Journal of medicinal chemistry (13.03.2008)
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Discovery of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors
Tong, Yunsong, Claiborne, Akiyo, Stewart, Kent D., Park, Chang, Kovar, Peter, Chen, Zehan, Credo, Robert B., Gu, Wen-Zhen, Gwaltney, Stephen L., Judge, Russell A., Zhang, Haiying, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-horng
Published in Bioorganic & medicinal chemistry (01.04.2007)
Published in Bioorganic & medicinal chemistry (01.04.2007)
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Thienopyridine urea inhibitors of KDR kinase
Heyman, H. Robin, Frey, Robin R., Bousquet, Peter F., Cunha, George A., Moskey, Maria D., Ahmed, Asma A., Soni, Niru B., Marcotte, Patrick A., Pease, Lori J., Glaser, Keith B., Yates, Melinda, Bouska, Jennifer J., Albert, Daniel H., Black-Schaefer, Candace L., Dandliker, Peter J., Stewart, Kent D., Rafferty, Paul, Davidsen, Steven K., Michaelides, Michael R., Curtin, Michael L.
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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