Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
Gay, Carl M., Stewart, C. Allison, Park, Elizabeth M., Diao, Lixia, Groves, Sarah M., Heeke, Simon, Nabet, Barzin Y., Fujimoto, Junya, Solis, Luisa M., Lu, Wei, Xi, Yuanxin, Cardnell, Robert J., Wang, Qi, Fabbri, Giulia, Cargill, Kasey R., Vokes, Natalie I., Ramkumar, Kavya, Zhang, Bingnan, Della Corte, Carminia M., Robson, Paul, Swisher, Stephen G., Roth, Jack A., Glisson, Bonnie S., Shames, David S., Wistuba, Ignacio I., Wang, Jing, Quaranta, Vito, Minna, John, Heymach, John V., Byers, Lauren Averett
Published in Cancer cell (08.03.2021)
Published in Cancer cell (08.03.2021)
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A wake-up call for cancer DNA damage: the role of Schlafen 11 (SLFN11) across multiple cancers
Zhang, Bingnan, Ramkumar, Kavya, Cardnell, Robert John, Gay, Carl Michael, Stewart, C. Allison, Wang, Wei-Lien, Fujimoto, Junya, Wistuba, Ignacio I., Byers, Lauren Averett
Published in British journal of cancer (09.11.2021)
Published in British journal of cancer (09.11.2021)
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Journal Article
Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC
Sen, Triparna, Della Corte, Carminia M., Milutinovic, Snezana, Cardnell, Robert J., Diao, Lixia, Ramkumar, Kavya, Gay, Carl M., Stewart, C. Allison, Fan, Youhong, Shen, Li, Hansen, Ryan J., Strouse, Bryan, Hedrick, Michael P., Hassig, Christian A., Heymach, John V., Wang, Jing, Byers, Lauren A.
Published in Journal of thoracic oncology (01.12.2019)
Published in Journal of thoracic oncology (01.12.2019)
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Journal Article
CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib
Sen, Triparna, Tong, Pan, Stewart, C Allison, Cristea, Sandra, Valliani, Aly, Shames, David S, Redwood, Abena B, Fan, You Hong, Li, Lerong, Glisson, Bonnie S, Minna, John D, Sage, Julien, Gibbons, Don L, Piwnica-Worms, Helen, Heymach, John V, Wang, Jing, Byers, Lauren Averett
Published in Cancer research (Chicago, Ill.) (15.07.2017)
Published in Cancer research (Chicago, Ill.) (15.07.2017)
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Journal Article
STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype
Della Corte, Carminia M., Sen, Triparna, Gay, Carl M., Ramkumar, Kavya, Diao, Lixia, Cardnell, Robert J., Rodriguez, Bertha Leticia, Stewart, C. Allison, Papadimitrakopoulou, Vassiliki A., Gibson, Laura, Fradette, Jared J., Wang, Qi, Fan, Youhong, Peng, David H., Negrao, Marcelo V., Wistuba, Ignacio I., Fujimoto, Junya, Solis Soto, Luisa M., Behrens, Carmen, Skoulidis, Ferdinandos, Heymach, John V., Wang, Jing, Gibbons, Don L., Byers, Lauren A.
Published in Journal of thoracic oncology (01.05.2020)
Published in Journal of thoracic oncology (01.05.2020)
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Journal Article
Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer
Cardnell, Robert J, Feng, Ying, Mukherjee, Seema, Diao, Lixia, Tong, Pan, Stewart, C Allison, Masrorpour, Fatemeh, Fan, YouHong, Nilsson, Monique, Shen, Yuqiao, Heymach, John V, Wang, Jing, Byers, Lauren A
Published in PloS one (07.04.2016)
Published in PloS one (07.04.2016)
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Journal Article
Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer
Allison Stewart, C, Tong, Pan, Cardnell, Robert J, Sen, Triparna, Li, Lerong, Gay, Carl M, Masrorpour, Fatemah, Fan, You, Bara, Rasha O, Feng, Ying, Ru, Yuanbin, Fujimoto, Junya, Kundu, Samrat T, Post, Leonard E, Yu, Karen, Shen, Yuqiao, Glisson, Bonnie S, Wistuba, Ignacio, Heymach, John V, Gibbons, Don L, Wang, Jing, Byers, Lauren Averett
Published in Oncotarget (25.04.2017)
Published in Oncotarget (25.04.2017)
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Journal Article
Chronic Estrus Disrupts Uterine Gland Development and Homeostasis
Stewart, C Allison, Stewart, M David, Wang, Ying, Mullen, Rachel D, Kircher, Bonnie K, Liang, Rui, Liu, Yu, Behringer, Richard R
Published in Endocrinology (Philadelphia) (01.03.2022)
Published in Endocrinology (Philadelphia) (01.03.2022)
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Journal Article
Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer
Ramkumar, Kavya, Tanimoto, Azusa, Della Corte, Carminia M, Stewart, C Allison, Wang, Qi, Shen, Li, Cardnell, Robert J, Wang, Jing, Polanska, Urszula M, Andersen, Courtney, Saeh, Jamal, Pease, J Elizabeth, Travers, Jon, Fabbri, Giulia, Gay, Carl M, Urosevic, Jelena, Byers, Lauren A
Published in Clinical cancer research (15.08.2023)
Published in Clinical cancer research (15.08.2023)
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Journal Article
CTNNB1 in Mesenchyme Regulates Epithelial Cell Differentiation during Müllerian Duct and Postnatal Uterine Development
Stewart, C. Allison, Wang, Ying, Bonilla-Claudio, Margarita, Martin, James F, Gonzalez, Gabriel, Taketo, Makoto M, Behringer, Richard R
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2013)
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2013)
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Journal Article
A Reversible Shift of Driver Dependence from EGFR to Notch1 in Non-Small Cell Lung Cancer as a Cause of Resistance to Tyrosine Kinase Inhibitors
Iommelli, Francesca, De Rosa, Viviana, Terlizzi, Cristina, Fonti, Rosa, Camerlingo, Rosa, Stoppelli, Maria Patrizia, Stewart, C Allison, Byers, Lauren Averett, Piwnica-Worms, David, Del Vecchio, Silvana
Published in Cancers (22.04.2021)
Published in Cancers (22.04.2021)
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Journal Article
Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy
Jo Ann Janovick, Stewart, M. David, Jacob, Darla, Martin, L. D., Deng, Jian Min, Stewart, C. Allison, Wang, Ying, Cornea, Anda, Chavali, Lakshmi, Lopez, Suhujey, Mitalipov, Shoukhrat, Kang, Eunju, Lee, Hyo-Sang, Manna, Pulak R., Stocco, Douglas M., Behringer, Richard R., Conn, P. Michael
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (24.12.2013)
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Journal Article
Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer
Cargill, Kasey R, Stewart, C Allison, Park, Elizabeth M, Ramkumar, Kavya, Gay, Carl M, Cardnell, Robert J, Wang, Qi, Diao, Lixia, Shen, Li, Fan, You-Hong, Chan, Wai Kin, Lorenzi, Philip L, Oliver, Trudy G, Wang, Jing, Byers, Lauren A
Published in Cancer & metabolism (23.09.2021)
Published in Cancer & metabolism (23.09.2021)
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Journal Article
Brief Report: Comprehensive Clinicogenomic Profiling of Small Cell Transformation From EGFR-Mutant NSCLC Informs Potential Therapeutic Targets
Zhang, Bingnan, Lewis, Whitney, Stewart, C. Allison, Morris, Benjamin B., Solis, Luisa M., Serrano, Alejandra, Xi, Yuanxin, Wang, Qi, Lopez, Elyse R., Concannon, Kyle, Heeke, Simon, Tang, Ximing, Raso, Gabriela, Cardnell, Robert J., Vokes, Natalie, Blumenschein, George, Elamin, Yasir, Fosella, Frank, Tsao, Anne, Skoulidis, Ferdinandos, Hume, Celyne Bueno, Sasak, Koji, Lewis, Jeff, Rinsurongkawong, Waree, Rinsurongkawong, Vadeerat, Lee, Jack, Tran, Hai, Zhang, Jianjun, Gibbons, Don, Vaporciyan, Ara, Wang, Jing, Park, Keunchil, Heymach, John V., Byers, Lauren A., Gay, Carl M., Le, Xiuning
Published in JTO clinical and research reports (01.02.2024)
Published in JTO clinical and research reports (01.02.2024)
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Journal Article
Mice Harboring Gnrhr E90K, a Mutation that Causes Protein Misfolding and Hypogonadotropic Hypogonadism in Humans, Exhibit Testis Size Reduction and Ovulation Failure
Stewart, M. David, Deng, Jian Ming, Stewart, C. Allison, Mullen, Rachael D, Wang, Ying, Lopez, Suhujey, Serna, M. Katalina, Huang, Cheng-Chiu, Janovick, Jo Ann, Pask, Andrew J, Schwartz, Robert J, Conn, P. Michael, Behringer, Richard R
Published in Molecular endocrinology (Baltimore, Md.) (01.11.2012)
Published in Molecular endocrinology (Baltimore, Md.) (01.11.2012)
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Journal Article
Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer
Stewart, C Allison, Gay, Carl M, Xi, Yuanxin, Sivajothi, Santhosh, Sivakamasundari, V, Fujimoto, Junya, Bolisetty, Mohan, Hartsfield, Patrice M, Balasubramaniyan, Veerakumar, Chalishazar, Milind D, Moran, Cesar, Kalhor, Neda, Stewart, John, Tran, Hai, Swisher, Stephen G, Roth, Jack A, Zhang, Jianjun, de Groot, John, Glisson, Bonnie, Oliver, Trudy G, Heymach, John V, Wistuba, Ignacio, Robson, Paul, Wang, Jing, Byers, Lauren Averett
Published in Nature cancer (01.04.2020)
Published in Nature cancer (01.04.2020)
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