Improved oral drug delivery: solubility limitations overcome by the use of prodrugs
Fleisher, David, Bong, Ramon, Stewart, Barbra H.
Published in Advanced Drug Delivery Reviews (22.05.1996)
Published in Advanced Drug Delivery Reviews (22.05.1996)
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Book Review
Journal Article
A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma
Stewart, B H, Kugler, A R, Thompson, P R, Bockbrader, H N
Published in Pharmaceutical research (01.02.1993)
Published in Pharmaceutical research (01.02.1993)
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Journal Article
Discrimination between drug candidates using models for evaluation of intestinal absorption
Stewart, Barbra H., Chan, O.Helen, Jezyk, Nancy, Fleisher, David
Published in Advanced drug delivery reviews (15.01.1997)
Published in Advanced drug delivery reviews (15.01.1997)
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Journal Article
Transport of pregabalin in rat intestine and Caco-2 monolayers
JEZYK, N, CHENG LI, STEWART, B. H, XIAOCHUN WU, BOCKBRADER, H. N, FLEISHER, D
Published in Pharmaceutical research (01.04.1999)
Published in Pharmaceutical research (01.04.1999)
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Journal Article
Improved Intestinal Transport of PD 158473, an N-methyl-d-Aspartate (NMDA) Antagonist, by Involvement of Multiple Transporters
Oh, Doo-Man, Han, Hyo-Kyung, Williamson, Rufus M., Bigge, Christopher F., Amidon, Gordon L., Stewart, Barbra H., Surendran, Narayanan
Published in Journal of pharmaceutical sciences (01.12.2002)
Published in Journal of pharmaceutical sciences (01.12.2002)
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Journal Article
HIV Protease Inhibitors Possessing a Novel, High-Affinity, and Achiral P1'/P2' Ligand with a Unique Pattern of in Vitro Resistance. Importance of a Conformationally-Restricted Template in the Design of Enzyme Inhibitors
Prasad, J. V. N. Vara, Lunney, Elizabeth A, Ferguson, Donna, Tummino, Peter J, Rubin, J. Ronald, Reyner, Eric L, Stewart, Barbra H, Guttendorf, Robert J, Domagala, John M
Published in Journal of the American Chemical Society (01.11.1995)
Published in Journal of the American Chemical Society (01.11.1995)
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Journal Article
Phosphate prodrugs of PD154075
Zhu, Z, Chen, H G, Goel, O P, Chan, O H, Stilgenbauer, L A, Stewart, B H
Published in Bioorganic & medicinal chemistry letters (15.05.2000)
Published in Bioorganic & medicinal chemistry letters (15.05.2000)
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Journal Article
Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) and dipeptide (hPEPT1) transporters for PD 158473, an NMDA antagonist
SURENDRAN, N, COVITZ, K.-M. Y, HAN, H.-K, SADEE, W, OH, D.-M, AMIDON, G. L, WILLIAMSON, R. M, BIGGE, C. F, STEWART, B. H
Published in Pharmaceutical research (01.03.1999)
Published in Pharmaceutical research (01.03.1999)
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Journal Article
Multiple-model evaluation of absorption of a tachykinin receptor antagonist
Chan, O.Helen, Sinz, Michael W., Stewart, Barbra H.
Published in Advanced drug delivery reviews (15.01.1997)
Published in Advanced drug delivery reviews (15.01.1997)
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Journal Article
Evaluation of Physicochemical Parameters Important to the Oral Bioavailability of Peptide-like Compounds: Implications for the Synthesis of Renin Inhibitors
Hamilton, Harriet W, Steinbaugh, Bruce A, Stewart, Barbra H, Chan, O. Helen, Schmid, Heidi L, Schroeder, Richard, Ryan, Michael J, Keiser, Joan, Taylor, Michael D
Published in Journal of medicinal chemistry (01.04.1995)
Published in Journal of medicinal chemistry (01.04.1995)
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Journal Article
Design of a Potent Combined Pseudopeptide Endothelin-A/Endothelin-B Receptor Antagonist, Ac-dBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252): Examination of Its Pharmacokinetic and Spectral Properties
Cody, Wayne L, He, John X, Reily, Michael D, Haleen, Stephen J, Walker, Donnelle M, Reyner, Eric L, Stewart, Barbra H, Doherty, Annette M
Published in Journal of medicinal chemistry (04.07.1997)
Published in Journal of medicinal chemistry (04.07.1997)
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Journal Article
Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans
Stewart, B H, Chan, O H, Lu, R H, Reyner, E L, Schmid, H L, Hamilton, H W, Steinbaugh, B A, Taylor, M D
Published in Pharmaceutical research (01.05.1995)
Published in Pharmaceutical research (01.05.1995)
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Journal Article
Use of immobilized artificial membrane chromatography for drug transport applications††Abbreviations: blood-brain barrier, BBB; bovine brain microvessel endothelial cells, BBMEC; calculated log distribution coefficient (Pallas, CompuDrug, Budapest, Hungary), ClogD; calculated log partition coefficient, ClogP; capacity factor on an IAM column, k¢IAM; capacity factor on a reversed-phase column, k¢w; log distribution coefficient, log D; immobilized artificial membrane, IAM; nonsteroidal antiinflamm
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Journal Article
Review: Improved oral drug delivery: solubility limitations overcome by the use of prodrugs
Fleisher, David, Bong, Ramon, Stewart, Barbra H
Published in Advanced drug delivery reviews (22.05.1996)
Published in Advanced drug delivery reviews (22.05.1996)
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Journal Article
CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs
Han, Hyo-kyung, Rhie, Julie K., Oh, Doo-man, Saito, Go, Hsu, Cheng-pang, Stewart, Barbra H., Amidon, Gordon L.
Published in Journal of pharmaceutical sciences (01.03.1999)
Published in Journal of pharmaceutical sciences (01.03.1999)
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Journal Article