Global mapping of antibody recognition of the hepatitis C virus E2 glycoprotein: Implications for vaccine design
Pierce, Brian G., Keck, Zhen-Yong, Lau, Patrick, Fauvelle, Catherine, Gowthaman, Ragul, Baumert, Thomas F., Fuerst, Thomas R., Mariuzza, Roy A., Foung, Steven K. H.
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2016)
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Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity
Prentoe, Jannick, Velázquez‐Moctezuma, Rodrigo, Foung, Steven K.H., Law, Mansun, Bukh, Jens
Published in Hepatology (Baltimore, Md.) (01.12.2016)
Published in Hepatology (Baltimore, Md.) (01.12.2016)
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Structural perspectives on HCV humoral immune evasion mechanisms
Sevvana, Madhumati, Keck, Zhenyong, Foung, Steven KH, Kuhn, Richard J
Published in Current opinion in virology (01.08.2021)
Published in Current opinion in virology (01.08.2021)
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Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus
Keck, Zhen-yong, Girard-Blanc, Christine, Wang, Wenyan, Lau, Patrick, Zuiani, Adam, Rey, Felix A, Krey, Thomas, Diamond, Michael S, Foung, Steven K H
Published in Journal of virology (15.03.2016)
Published in Journal of virology (15.03.2016)
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Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate
Keck, Zhen-yong, Xia, Jinming, Wang, Yong, Wang, Wenyan, Krey, Thomas, Prentoe, Jannick, Carlsen, Thomas, Li, Angela Ying-Jian, Patel, Arvind H, Lemon, Stanley M, Bukh, Jens, Rey, Felix A, Foung, Steven K H
Published in PLoS pathogens (01.04.2012)
Published in PLoS pathogens (01.04.2012)
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Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice
Keck, Zhen‐Yong, Wang, Yong, Lau, Patrick, Lund, Garry, Rangarajan, Sneha, Fauvelle, Catherine, Liao, Grant C., Holtsberg, Frederick W., Warfield, Kelly L., Aman, M. Javad, Pierce, Brian G., Fuerst, Thomas R., Bailey, Justin R., Baumert, Thomas F., Mariuzza, Roy A., Kneteman, Norman M., Foung, Steven K.H.
Published in Hepatology (Baltimore, Md.) (01.12.2016)
Published in Hepatology (Baltimore, Md.) (01.12.2016)
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Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies
Meola, Annalisa, Tarr, Alexander W, England, Patrick, Meredith, Luke W, McClure, C Patrick, Foung, Steven K H, McKeating, Jane A, Ball, Jonathan K, Rey, Felix A, Krey, Thomas
Published in Journal of virology (01.02.2015)
Published in Journal of virology (01.02.2015)
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Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes
Bankwitz, Dorothea, Steinmann, Eike, Bitzegeio, Julia, Ciesek, Sandra, Friesland, Martina, Herrmann, Eva, Zeisel, Mirjam B, Baumert, Thomas F, Keck, Zhen-yong, Foung, Steven K H, Pécheur, Eve-Isabelle, Pietschmann, Thomas
Published in Journal of Virology (01.06.2010)
Published in Journal of Virology (01.06.2010)
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Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a
Carlsen, Thomas H.R., Pedersen, Jannie, Prentoe, Jannick C., Giang, Erick, Keck, Zhen‐Yong, Mikkelsen, Lotte S., Law, Mansun, Foung, Steven K.H., Bukh, Jens
Published in Hepatology (Baltimore, Md.) (01.11.2014)
Published in Hepatology (Baltimore, Md.) (01.11.2014)
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Journal Article
Viral evasion and challenges of hepatitis C virus vaccine development
Pierce, Brian G, Keck, Zhen-Yong, Foung, Steven KH
Published in Current opinion in virology (01.10.2016)
Published in Current opinion in virology (01.10.2016)
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Journal Article
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site
Howell, Katie A., Qiu, Xiangguo, Brannan, Jennifer M., Bryan, Christopher, Davidson, Edgar, Holtsberg, Frederick W., Wec, Anna Z., Shulenin, Sergey, Biggins, Julia E., Douglas, Robin, Enterlein, Sven G., Turner, Hannah L., Pallesen, Jesper, Murin, Charles D., He, Shihua, Kroeker, Andrea, Vu, Hong, Herbert, Andrew S., Fusco, Marnie L., Nyakatura, Elisabeth K., Lai, Jonathan R., Keck, Zhen-Yong, Foung, Steven K.H., Saphire, Erica Ollmann, Zeitlin, Larry, Ward, Andrew B., Chandran, Kartik, Doranz, Benjamin J., Kobinger, Gary P., Dye, John M., Aman, M. Javad
Published in Cell reports (Cambridge) (17.05.2016)
Published in Cell reports (Cambridge) (17.05.2016)
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Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies
Pedersen, Jannie, Carlsen, Thomas H.R., Prentoe, Jannick, Ramirez, Santseharay, Jensen, Tanja B., Forns, Xavier, Alter, Harvey, Foung, Steven K.H., Law, Mansun, Gottwein, Judith, Weis, Nina, Bukh, Jens
Published in Hepatology (Baltimore, Md.) (01.11.2013)
Published in Hepatology (Baltimore, Md.) (01.11.2013)
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CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells
Witteveldt, Jeroen, Evans, Matthew J, Bitzegeio, Julia, Koutsoudakis, George, Owsianka, Ania M, Angus, Allan G. N, Keck, Zhen-Yong, Foung, Steven K. H, Pietschmann, Thomas, Rice, Charles M, Patel, Arvind H
Published in Journal of general virology (01.01.2009)
Published in Journal of general virology (01.01.2009)
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Journal Article
Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein
Owsianka, Ania M, Tarr, Alexander W, Keck, Zhen-Yong, Li, Ta-Kai, Witteveldt, Jeroen, Adair, Richard, Foung, Steven K. H, Ball, Jonathan K, Patel, Arvind H
Published in Journal of general virology (01.03.2008)
Published in Journal of general virology (01.03.2008)
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Journal Article
Definition of a Conserved Immunodominant Domain on Hepatitis C Virus E2 Glycoprotein by Neutralizing Human Monoclonal Antibodies
KECK, Zhen-Yong, LI, Ta-Kai, JINMING XIA, GAL-TANAMY, Meital, OLSON, Oakley, LI, Sophia H, PATEL, Arvind H, BALL, Jonathan K, LEMON, Stanley M, FOUNG, Steven K. H
Published in Journal of Virology (01.06.2008)
Published in Journal of Virology (01.06.2008)
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Journal Article
Mutations in Hepatitis C Virus E2 Located outside the CD81 Binding Sites Lead to Escape from Broadly Neutralizing Antibodies but Compromise Virus Infectivity
KECK, Zhen-Yong, LI, Sophia H, FOUNG, Steven K. H, JINMING XIA, VON HAHN, Thomas, BALFE, Peter, MCKEATING, Jane A, WITTEVELDT, Jeroen, PATEL, Arvind H, ALTER, Harvey, RICE, Charles M
Published in Journal of Virology (15.06.2009)
Published in Journal of Virology (15.06.2009)
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Journal Article
Hepatitis C Virus E2 Has Three Immunogenic Domains Containing Conformational Epitopes with Distinct Properties and Biological Functions
KECK, Zhen-Yong, OP DE BEECK, Anne, HADLOCK, Kenneth G, JINMING XIA, LI, Ta-Kai, DUBUISSON, Jean, FOUNG, Steven K. H
Published in Journal of Virology (01.09.2004)
Published in Journal of Virology (01.09.2004)
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Journal Article
In vitro selection of a neutralization-resistant hepatitis C virus escape mutant
Gal-Tanamy, Meital, Keck, Zhen-Yong, Yi, MinKyung, McKeating, Jane A, Patel, Arvind H, Foung, Steven K.H, Lemon, Stanley M
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2008)
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Mutations within a Conserved Region of the Hepatitis C Virus E2 Glycoprotein That Influence Virus-Receptor Interactions and Sensitivity to Neutralizing Antibodies
Dhillon, Simrat, Witteveldt, Jeroen, Gatherer, Derek, Owsianka, Ania M, Zeisel, Mirjam B, Zahid, Muhammad N, Rychłowska, Malgorzata, Foung, Steven K H, Baumert, Thomas F, Angus, Allan G N, Patel, Arvind H
Published in Journal of Virology (01.06.2010)
Published in Journal of Virology (01.06.2010)
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Journal Article
Non-random Escape Pathways from a Broadly Neutralizing Human Monoclonal Antibody Map to a Highly Conserved Region on the Hepatitis C Virus E2 Glycoprotein Encompassing Amino Acids 412-423: e1004297
Keck, Zhen-yong, Angus, Allan GN, Wang, Wenyan, Lau, Patrick, Wang, Yong, Gatherer, Derek, Patel, Arvind H, Foung, Steven KH
Published in PLoS pathogens (01.08.2014)
Published in PLoS pathogens (01.08.2014)
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