Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis
Rybak, Jeffrey M, Dickens, C Michael, Parker, Josie E, Caudle, Kelly E, Manigaba, Kayihura, Whaley, Sarah G, Nishimoto, Andrew T, Luna-Tapia, Arturo, Roy, Sujoy, Zhang, Qing, Barker, Katherine S, Palmer, Glen E, Sutter, Thomas R, Homayouni, Ramin, Wiederhold, Nathan P, Kelly, Steven L, Rogers, P David
Published in Antimicrobial agents and chemotherapy (01.09.2017)
Published in Antimicrobial agents and chemotherapy (01.09.2017)
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Evolution of GOLDEN2-LIKE gene function in C3 and C4 plants
Wang, Peng, Fouracre, Jim, Kelly, Steven, Karki, Shanta, Gowik, Udo, Aubry, Sylvain, Shaw, Michael K., Westhoff, Peter, Slamet-Loedin, Inez H., Quick, W. Paul, Hibberd, Julian M., Langdale, Jane A.
Published in Planta (01.02.2013)
Published in Planta (01.02.2013)
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Horizontal transfer of an adaptive chimeric photoreceptor from bryophytes to ferns
Li, Fay-Wei, Villarreal, Juan Carlos, Kelly, Steven, Rothfels, Carl J., Melkonian, Michael, Frangedakis, Eftychios, Ruhsam, Markus, Sigel, Erin M., Der, Joshua P., Pittermann, Jarmila, Burge, Dylan O., Pokorny, Lisa, Larsson, Anders, Chen, Tao, Weststrand, Stina, Thomas, Philip, Carpenter, Eric, Zhang, Yong, Tian, Zhijian, Li Chen, Yan, Zhixiang, Zhu, Ying, Sun, Xiao, Wang, Jun, Stevenson, Dennis W., Crandall-Stotler, Barbara J., Shaw, A. Jonathan, Deyholos, Michael K., Soltis, Douglas E., Graham, Sean W., Windham, Michael D., Langdale, Jane A., Wong, Gane Ka-Shu, Mathews, Sarah, Pryer, Kathleen M.
Published in Proceedings of the National Academy of Sciences - PNAS (06.05.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (06.05.2014)
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Widespread distribution of resistance to triazole fungicides in Brazilian populations of the wheat blast pathogen
Poloni, Nadia Maria, Carvalho, Giselle, Vicentini, Samara, Dorigan, Adriano, Maciel, João Leodato, McDonald, Bruce A., Moreira, Silvino, Hawkins, Nichola, Fraaije, Bart A., Kelly, Diane E., Kelly, Steven L., Ceresini, Paulo C.
Published in Plant pathology (01.02.2021)
Published in Plant pathology (01.02.2021)
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Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma
Griffiths, William J., Crick, Peter J., Meljon, Anna, Theofilopoulos, Spyridon, Abdel-Khalik, Jonas, Yutuc, Eylan, Parker, Josie E., Kelly, Diane E., Kelly, Steven L., Arenas, Ernest, Wang, Yuqin
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.02.2019)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.02.2019)
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Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14-α-Demethylase
PARKER, Josie E, WARRILOW, Andrew G. S, COOLS, Hans J, FRAAIJE, Bart A, LUCAS, John A, RIGDOVA, Katarina, GRIFFITHS, William J, KELLY, Diane E, KELLY, Steven L
Published in Applied and Environmental Microbiology (01.03.2013)
Published in Applied and Environmental Microbiology (01.03.2013)
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Pilot Study of the Juvenile Dermatomyositis Consensus Treatment Plans: A CARRA Registry Study
Liu, Kuan, Tomlinson, George, Reed, Ann M, Huber, Adam M, Saarela, Olli, Bout-Tabaku, Sharon M, Curran, Megan, Dvergsten, Jeffrey A, Eberhard, Barbara A, Jung, Lawrence K, Kim, Susan, Ringold, Sarah, Rouster-Steven, Kelly A, Tesher, Melissa, Wahezi, Dawn M, Feldman, Brian M
Published in Journal of rheumatology (01.01.2021)
Published in Journal of rheumatology (01.01.2021)
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Journal Article
Resistance to antifungals that target CYP51
Parker, Josie E., Warrilow, Andrew G. S., Price, Claire L., Mullins, Jonathan G. L., Kelly, Diane E., Kelly, Steven L.
Published in Journal of chemical biology (01.10.2014)
Published in Journal of chemical biology (01.10.2014)
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Cytochromes P450 and drug discovery
Lamb, David C, Waterman, Michael R, Kelly, Steven L, Guengerich, F Peter
Published in Current opinion in biotechnology (01.12.2007)
Published in Current opinion in biotechnology (01.12.2007)
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Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B
WARRILOW, Andrew G. S, MELO, Nadja, MARTEL, Claire M, PARKER, Josie E, NES, W. David, KELLY, Steven L, KELLY, Diane E
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
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Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in ERG2 as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr
Asadzadeh, Mohammad, Alfouzan, Wadha, Parker, Josie E, Meis, Jacques F, Kelly, Steven L, Joseph, Leena, Ahmad, Suhail
Published in Microbiology spectrum (17.08.2023)
Published in Microbiology spectrum (17.08.2023)
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Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans
Binjubair, Faizah A., Parker, Josie E., Warrilow, Andrew G., Puri, Kalika, Braidley, Peter J., Tatar, Esra, Kelly, Steven L., Kelly, Diane E., Simons, Claire
Published in ChemMedChem (20.07.2020)
Published in ChemMedChem (20.07.2020)
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Journal Article
Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51)
WARRILOW, Andrew G. S, MARTEL, Claire M, PARKER, Josie E, MELO, Nadja, LAMB, David C, NES, W. David, KELLY, Diane E, KELLY, Steven L
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
Published in Antimicrobial Agents and Chemotherapy (01.10.2010)
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Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site
Zhao, Bin, Lei, Li, Vassylyev, Dmitry G., Lin, Xin, Cane, David E., Kelly, Steven L., Yuan, Hang, Lamb, David C., Waterman, Michael R.
Published in The Journal of biological chemistry (25.12.2009)
Published in The Journal of biological chemistry (25.12.2009)
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Journal Article
Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)
Lamb, David C, Warrilow, Andrew G S, Rolley, Nicola J, Parker, Josie E, Nes, W David, Smith, Stephen N, Kelly, Diane E, Kelly, Steven L
Published in Antimicrobial agents and chemotherapy (01.08.2015)
Published in Antimicrobial agents and chemotherapy (01.08.2015)
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The First Virally Encoded Cytochrome P450
LAMB, David C, LI LEI, WARRILOW, Andrew G. S, LEPESHEVA, Galina I, MULLINS, Jonathan G. L, WATERMAN, Michael R, KELLY, Steven L
Published in Journal of Virology (15.08.2009)
Published in Journal of Virology (15.08.2009)
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Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens
Warrilow, Andrew G.S., Parker, Josie E., Price, Claire L., Rolley, Nicola J., Nes, W. David, Kelly, Diane E., Kelly, Steven L.
Published in International journal of antimicrobial agents (01.10.2019)
Published in International journal of antimicrobial agents (01.10.2019)
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In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection
Colley, Thomas, Sehra, Gurpreet, Chowdhary, Anuradha, Alanio, Alexandre, Kelly, Steven L, Kizawa, Yasuo, Armstrong-James, Darius, Fisher, Matthew C, Warrilow, Andrew G S, Parker, Josie E, Kelly, Diane E, Kimura, Genki, Nishimoto, Yuki, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, McConville, Matthew, King-Underwood, John, Naylor, Alan, Bretagne, Stéphane, Murray, John, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Published in Antimicrobial agents and chemotherapy (01.05.2018)
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Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii
Zhou, Wenxu, Warrilow, Andrew G.S., Thomas, Crista D., Ramos, Emilio, Parker, Josie E., Price, Claire L., Vanderloop, Boden H., Fisher, Paxtyn M., Loftis, Michael D., Kelly, Diane E., Kelly, Steven L., Nes, W. David
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.10.2018)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.10.2018)
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