APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
Zhao, Jing, Fu, Yuan, Yamazaki, Yu, Ren, Yingxue, Davis, Mary D., Liu, Chia-Chen, Lu, Wenyan, Wang, Xue, Chen, Kai, Cherukuri, Yesesri, Jia, Lin, Martens, Yuka A., Job, Lucy, Shue, Francis, Nguyen, Thanh Thanh, Younkin, Steven G., Graff-Radford, Neill R., Wszolek, Zbigniew K., Brafman, David A., Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun
Published in Nature communications (02.11.2020)
Published in Nature communications (02.11.2020)
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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
De Jager, Philip L, Srivastava, Gyan, Lunnon, Katie, Burgess, Jeremy, Schalkwyk, Leonard C, Yu, Lei, Eaton, Matthew L, Keenan, Brendan T, Ernst, Jason, McCabe, Cristin, Tang, Anna, Raj, Towfique, Replogle, Joseph, Brodeur, Wendy, Gabriel, Stacey, Chai, High S, Younkin, Curtis, Younkin, Steven G, Zou, Fanggeng, Szyf, Moshe, Epstein, Charles B, Schneider, Julie A, Bernstein, Bradley E, Meissner, Alex, Ertekin-Taner, Nilufer, Chibnik, Lori B, Kellis, Manolis, Mill, Jonathan, Bennett, David A
Published in Nature neuroscience (01.09.2014)
Published in Nature neuroscience (01.09.2014)
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Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight
Ebbert, Mark T W, Jensen, Tanner D, Jansen-West, Karen, Sens, Jonathon P, Reddy, Joseph S, Ridge, Perry G, Kauwe, John S K, Belzil, Veronique, Pregent, Luc, Carrasquillo, Minerva M, Keene, Dirk, Larson, Eric, Crane, Paul, Asmann, Yan W, Ertekin-Taner, Nilufer, Younkin, Steven G, Ross, Owen A, Rademakers, Rosa, Petrucelli, Leonard, Fryer, John D
Published in Genome Biology (20.05.2019)
Published in Genome Biology (20.05.2019)
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Innate immunity receptor CD36 promotes cerebral amyloid angiopathy
Park, Laibaik, Zhou, Joan, Zhou, Ping, Pistick, Rose, Jamal, Sleiman El, Younkin, Linda, Pierce, Joseph, Arreguin, Andrea, Anrather, Josef, Younkin, Steven G., Carlson, George A., McEwen, Bruce S., ladecola, Costantino
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2013)
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Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases
Allen, Mariet, Carrasquillo, Minerva M., Funk, Cory, Heavner, Benjamin D., Zou, Fanggeng, Younkin, Curtis S., Burgess, Jeremy D., Chai, High-Seng, Crook, Julia, Eddy, James A., Li, Hongdong, Logsdon, Ben, Peters, Mette A., Dang, Kristen K., Wang, Xue, Serie, Daniel, Wang, Chen, Nguyen, Thuy, Lincoln, Sarah, Malphrus, Kimberly, Bisceglio, Gina, Li, Ma, Golde, Todd E., Mangravite, Lara M., Asmann, Yan, Price, Nathan D., Petersen, Ronald C., Graff-Radford, Neill R., Dickson, Dennis W., Younkin, Steven G., Ertekin-Taner, Nilüfer
Published in Scientific data (11.10.2016)
Published in Scientific data (11.10.2016)
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Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases
Allen, Mariet, Wang, Xue, Burgess, Jeremy D., Watzlawik, Jens, Serie, Daniel J., Younkin, Curtis S., Nguyen, Thuy, Malphrus, Kimberly G., Lincoln, Sarah, Carrasquillo, Minerva M., Ho, Charlotte, Chakrabarty, Paramita, Strickland, Samantha, Murray, Melissa E., Swarup, Vivek, Geschwind, Daniel H., Seyfried, Nicholas T., Dammer, Eric B., Lah, James J., Levey, Allan I., Golde, Todd E., Funk, Cory, Li, Hongdong, Price, Nathan D., Petersen, Ronald C., Graff-Radford, Neill R., Younkin, Steven G., Dickson, Dennis W., Crook, Julia R., Asmann, Yan W., Ertekin-Taner, Nilüfer
Published in Alzheimer's & dementia (01.03.2018)
Published in Alzheimer's & dementia (01.03.2018)
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Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β
Park, Laibaik, Wang, Gang, Zhou, Ping, Zhou, Joan, Pitstick, Rose, Previti, Mary Lou, Younkin, Linda, Younkin, Steven G., Van Nostrand, William E., Cho, Sunghee, Anrather, Josef, Carlson, George A., Iadecola, Costantino, Südhof, Thomas C.
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2011)
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Alzheimer's disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions
Wang, Xue, Allen, Mariet, İş, Özkan, Reddy, Joseph S, Tutor-New, Frederick Q, Castanedes Casey, Monica, Carrasquillo, Minerva M, Oatman, Stephanie R, Min, Yuhao, Asmann, Yan W, Funk, Cory, Nguyen, Thuy, Ho, Charlotte Cg, Malphrus, Kimberly G, Seyfried, Nicholas T, Levey, Allan I, Younkin, Steven G, Murray, Melissa E, Dickson, Dennis W, Price, Nathan D, Golde, Todd E, Ertekin-Taner, Nilüfer
Published in The Journal of clinical investigation (18.01.2022)
Published in The Journal of clinical investigation (18.01.2022)
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Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Jankowsky, Joanna L, Melnikova, Tatiana, Fadale, Daniel J, Xu, Guilian M, Slunt, Hilda H, Gonzales, Victoria, Younkin, Linda H, Younkin, Steven G, Borchelt, David R, Savonenko, Alena V
Published in The Journal of neuroscience (25.05.2005)
Published in The Journal of neuroscience (25.05.2005)
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Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study
Simino, Jeannette, Wang, Zhiying, Bressler, Jan, Chouraki, Vincent, Yang, Qiong, Younkin, Steven G, Seshadri, Sudha, Fornage, Myriam, Boerwinkle, Eric, Mosley, Jr, Thomas H
Published in PloS one (13.07.2017)
Published in PloS one (13.07.2017)
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Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies
Wickland, Daniel P, Ren, Yingxue, Sinnwell, Jason P, Reddy, Joseph S, Pottier, Cyril, Sarangi, Vivekananda, Carrasquillo, Minerva M, Ross, Owen A, Younkin, Steven G, Ertekin-Taner, Nilüfer, Rademakers, Rosa, Hudson, Matthew E, Mainzer, Liudmila Sergeevna, Biernacka, Joanna M, Asmann, Yan W
Published in PloS one (16.04.2021)
Published in PloS one (16.04.2021)
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Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience
Ridge, Perry G, Karch, Celeste M, Hsu, Simon, Arano, Ivan, Teerlink, Craig C, Ebbert, Mark T W, Gonzalez Murcia, Josue D, Farnham, James M, Damato, Anna R, Allen, Mariet, Wang, Xue, Harari, Oscar, Fernandez, Victoria M, Guerreiro, Rita, Bras, Jose, Hardy, John, Munger, Ronald, Norton, Maria, Sassi, Celeste, Singleton, Andrew, Younkin, Steven G, Dickson, Dennis W, Golde, Todd E, Price, Nathan D, Ertekin-Taner, Nilüfer, Cruchaga, Carlos, Goate, Alison M, Corcoran, Christopher, Tschanz, JoAnn, Cannon-Albright, Lisa A, Kauwe, John S K
Published in Genome medicine (29.11.2017)
Published in Genome medicine (29.11.2017)
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Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
Zhao, Jing, Fu, Yuan, Yamazaki, Yu, Ren, Yingxue, Davis, Mary D., Liu, Chia-Chen, Lu, Wenyan, Wang, Xue, Chen, Kai, Cherukuri, Yesesri, Jia, Lin, Martens, Yuka A., Job, Lucy, Shue, Francis, Nguyen, Thanh Thanh, Younkin, Steven G., Graff-Radford, Neill R., Wszolek, Zbigniew K., Brafman, David A., Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun
Published in Nature communications (05.05.2021)
Published in Nature communications (05.05.2021)
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Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains
Wahrle, Suzanne, Das, Pritam, Nyborg, Andrew C., McLendon, Chris, Shoji, Mikio, Kawarabayashi, Takeshi, Younkin, Linda H., Younkin, Steven G., Golde, Todd E.
Published in Neurobiology of disease (01.02.2002)
Published in Neurobiology of disease (01.02.2002)
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Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein
Niwa, Kiyoshi, Kazama, Ken, Younkin, Linda, Younkin, Steven G, Carlson, George A, Iadecola, Costantino
Published in American journal of physiology. Heart and circulatory physiology (01.07.2002)
Published in American journal of physiology. Heart and circulatory physiology (01.07.2002)
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Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease
Chung, Jaeyoon, Zhang, Xiaoling, Allen, Mariet, Wang, Xue, Ma, Yiyi, Beecham, Gary, Montine, Thomas J, Younkin, Steven G, Dickson, Dennis W, Golde, Todd E, Price, Nathan D, Ertekin-Taner, Nilüfer, Lunetta, Kathryn L, Mez, Jesse, Mayeux, Richard, Haines, Jonathan L, Pericak-Vance, Margaret A, Schellenberg, Gerard, Jun, Gyungah R, Farrer, Lindsay A
Published in Alzheimer's research & therapy (20.02.2018)
Published in Alzheimer's research & therapy (20.02.2018)
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Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
Ertekin-Taner, Nilufer, Graff-Radford, Neill, Younkin, Linda H., Eckman, Christopher, Baker, Matthew, Adamson, Jennifer, Ronald, James, Blangero, John, Hutton, Michael, Younkin, Steven G.
Published in Science (American Association for the Advancement of Science) (22.12.2000)
Published in Science (American Association for the Advancement of Science) (22.12.2000)
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Investigation of 15 of the top candidate genes for late-onset Alzheimer’s disease
Belbin, Olivia, Carrasquillo, Minerva M., Crump, Michael, Culley, Oliver J., Hunter, Talisha A., Ma, Li, Bisceglio, Gina, Zou, Fanggeng, Allen, Mariet, Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., Morgan, Kevin, Younkin, Steven G.
Published in Human genetics (01.03.2011)
Published in Human genetics (01.03.2011)
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The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice
Wen, Paul H., Hof, Patrick R., Chen, Xiaoping, Gluck, Karen, Austin, Gregory, Younkin, Steven G., Younkin, Linda H., DeGasperi, Rita, Gama Sosa, Miguel A., Robakis, Nikolaos K., Haroutunian, Vahram, Elder, Gregory A.
Published in Experimental neurology (01.08.2004)
Published in Experimental neurology (01.08.2004)
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