BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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Journal Article
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Martin, Laetitia J, Koegl, Manfred, Bader, Gerd, Cockcroft, Xiao-Ling, Fedorov, Oleg, Fiegen, Dennis, Gerstberger, Thomas, Hofmann, Marco H, Hohmann, Anja F, Kessler, Dirk, Knapp, Stefan, Knesl, Petr, Kornigg, Stefan, Müller, Susanne, Nar, Herbert, Rogers, Catherine, Rumpel, Klaus, Schaaf, Otmar, Steurer, Steffen, Tallant, Cynthia, Vakoc, Christopher R, Zeeb, Markus, Zoephel, Andreas, Pearson, Mark, Boehmelt, Guido, McConnell, Darryl
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Journal Article
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6
Kerres, Nina, Steurer, Steffen, Schlager, Stefanie, Bader, Gerd, Berger, Helmut, Caligiuri, Maureen, Dank, Christian, Engen, John R., Ettmayer, Peter, Fischerauer, Bernhard, Flotzinger, Gerlinde, Gerlach, Daniel, Gerstberger, Thomas, Gmaschitz, Teresa, Greb, Peter, Han, Bingsong, Heyes, Elizabeth, Iacob, Roxana E., Kessler, Dirk, Kölle, Heike, Lamarre, Lyne, Lancia, David R., Lucas, Simon, Mayer, Moriz, Mayr, Katharina, Mischerikow, Nikolai, Mück, Katja, Peinsipp, Christoph, Petermann, Oliver, Reiser, Ulrich, Rudolph, Dorothea, Rumpel, Klaus, Salomon, Carina, Scharn, Dirk, Schnitzer, Renate, Schrenk, Andreas, Schweifer, Norbert, Thompson, Diane, Traxler, Elisabeth, Varecka, Roland, Voss, Tilman, Weiss-Puxbaum, Alexander, Winkler, Sandra, Zheng, Xiaozhang, Zoephel, Andreas, Kraut, Norbert, McConnell, Darryl, Pearson, Mark, Koegl, Manfred
Published in Cell reports (Cambridge) (19.09.2017)
Published in Cell reports (Cambridge) (19.09.2017)
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Journal Article
Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions
Popow, Johannes, Arnhof, Heribert, Bader, Gerd, Berger, Helmut, Ciulli, Alessio, Covini, David, Dank, Christian, Gmaschitz, Teresa, Greb, Peter, Karolyi-Özguer, Jale, Koegl, Manfred, McConnell, Darryl B, Pearson, Mark, Rieger, Maria, Rinnenthal, Joerg, Roessler, Vanessa, Schrenk, Andreas, Spina, Markus, Steurer, Steffen, Trainor, Nicole, Traxler, Elisabeth, Wieshofer, Corinna, Zoephel, Andreas, Ettmayer, Peter
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Journal Article
Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition
Hohmann, Anja F, Martin, Laetitia J, Minder, Jessica L, Roe, Jae-Seok, Shi, Junwei, Steurer, Steffen, Bader, Gerd, McConnell, Darryl, Pearson, Mark, Gerstberger, Thomas, Gottschamel, Teresa, Thompson, Diane, Suzuki, Yutaka, Koegl, Manfred, Vakoc, Christopher R
Published in Nature chemical biology (01.09.2016)
Published in Nature chemical biology (01.09.2016)
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Journal Article
A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation
Waizenegger, Irene C, Baum, Anke, Steurer, Steffen, Stadtmüller, Heinz, Bader, Gerd, Schaaf, Otmar, Garin-Chesa, Pilar, Schlattl, Andreas, Schweifer, Norbert, Haslinger, Christian, Colbatzky, Florian, Mousa, Sien, Kalkuhl, Arno, Kraut, Norbert, Adolf, Günther R
Published in Molecular cancer therapeutics (01.03.2016)
Published in Molecular cancer therapeutics (01.03.2016)
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Journal Article
Abstract 3849: Structure-based PROTAC design demonstrates BAF complex ATPase vulnerabilities in cancer
Koegl, Manfred, Farnaby, William, Whitworth, Claire, Roy, Michael, Diers, Emelyne, Trainor, Nicole, Steurer, Steffen, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Gallant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Lorenz, Romario, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Rinnenthal, Joerg, Arnnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 3354: Chemically induced degradation of the transcription factor BCL6
Kerres, Nina, Steurer, Steffen, Schlager, Stefanie, Bader, Gerd, Caligiuri, Maureen, Dank, Christian, Engen, John R., Ettmayer, Peter, Gerlach, Daniel, Gerstberger, Thomas, Han, Bingsong, Iacob, Roxana E., Kessler, Dirk, Lancia, David R., Moriz, Mayer, Mischerikow, Nikolai, Rumpel, Klaus, Schnitzer, Renate, Voss, Tilman, Zheng, Xiaozhang, Zoephel, Andreas, Kraut, Norbert, McConnell, Darryl, Pearson, Mark, Koegl, Manfred
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio
Published in Nature chemical biology (01.08.2019)
Published in Nature chemical biology (01.08.2019)
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Journal Article
Abstract LB-206: A bromodomain-swap allele demonstrates that on-target chemical inhibition of BRD9 limits the proliferation of acute myeloid leukemia cells
Hohmann, Anja F., Martin, Laetitia J., Minder, Jessica, Roe, Jae-Seok, Shi, Junwei, Steurer, Steffen, Bader, Gerd, McConnell, Darryl, Pearson, Mark, Gerstberger, Thomas, Gottschamel, Teresa, Thompson, Diane, Suzuki, Yutaka, Koegl, Manfred, Vakoc, Christopher
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 1525: Chemically induced degradation of the oncogenic transcription factor BCL6
Kerres, Nina, Steurer, Steffen, Schlager, Stefanie, Bader, Gerd, Berger, Helmut, Blake, Sophia, Caligiuri, Maureen, Engen, John, Ettmayer, Peter, Gerstberger, Thomas, Gerlach, Daniel, Jacob, Roxana, Lucas, Simon, Mayer, Moriz, Nikolai, Mischerikow, Klaus, Rumpel, Dirk, Scharn, Renate, Schnitzer, Voss, Tilman, Andreas, Zoephel, Kraut, Norbert, McConnell, Darryl, Mark, Pearson, Koegl, Manfred
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 2344: Modeling 1st- and 2nd-line therapy of BRAF mutant melanoma using a novel BRAF inhibitor with DFG-out binding mode
Waizenegger, Irene C., Baum, Anke, Stadtmüller, Heinz, Steurer, Steffen, Bader, Gerd, Garin-Chesa, Pilar, Schweifer, Norbert, Bernthaler, Andreas, Haslinger, Christian, Schaaf, Otmar, Mousa, Sien, Colbatzky, Florian, Adolf, Günther R.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
PYRIDO (5, 4-D) PYRIMIDINES AS CELL PROLIFERATION INHIBITORS
ETTMAYER PETER, WAIZENEGGER IRENE, ZAHN STEPHAN KARL, MANTOULIDIS ANDREAS, KLEIN CHRISTIAN, STEURER STEFFEN, DAHMANN GEORG
Year of Publication 10.06.2011
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Year of Publication 10.06.2011
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